| Budget Amount *help |
¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥700,000 (Direct Cost: ¥700,000)
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| Research Abstract |
The following works have been performed for the standardization of the cardiac function in the elderly population.
1)In the first year of this project, a two-year working group was organized in the Japanese Society of Nuclear Medicine (JSNM). By the cooperation of the members from Nihon Medical University, Keio-Gijuku University, Hokkaido University, Kanazawa University, Toranomon Hospital, Toho University, myocardial standard data were accumulated. The projects were approved by the ethical committees in each institution. The data were transferred to the format of the workstation in the center office of Kanazawa University. During this study, we took contact with Dr. Germano (Cedars Sinai Medical Center, USA) and Dr. Garcia (Emory University), who are the developer of the commonly available myocardial perfusion quantification software. The collaboration worked effectively in the progress of this project.
2)In the JSNM working group activity, which has been performed from November 2005 to
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October 2007, standard data of myocardial perfusion, fatty acid metabolism (1-123 BMIPP) and sympathetic imaging (1-123 MIBG) were generated. By the deadline of the grants-in-aid, we finished the standardization of myocardial perfusion map. The final report from JSNM working group will be published as a report from the JSNM activity.
3)Myocardial phantoms were generated and the quantitative data for 1-123 radiopharmaceutical was validated. The data acquisition was performed with the standard phantom, and standardized for the different types of cameras. Multiple-window acquisition method for 1-123 radiopharmaceutical was the best practical choice for the reliable data.
4)A multi-center study, J-ACCESS (Nishimura, Tsunehiko, Chief investigator) was the first prognostic study in Japan in the field of Nuclear Cardiology. Among 4670 patients data accumulated for the study, 268 subjects were selected as the low-risk population for coronary artery disease. When standard values were calculated with respect to left ventricular ejection fraction and volumes, significant differences were demonstrated between female and male, and also among different age groups. Importance of population specific standard was emphasized by this study. Less
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