| Project/Area Number |
17591264
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
ISODA Hiroyoshi Kyoto Univ., Graduate School of Medicine, Assistant Professor, 医学研究科, 助手 (20309214)
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| Co-Investigator(Kenkyū-buntansha) |
TOGASHI Kaori Kyoto Univ., Graduate School of Medicine, Professor, 医学研究科, 教授 (90135484)
SHIBATA Toshiya Kyoto Univ., Graduate School of Medicine, Associate Professor, 医学研究科, 助教授 (60162632)
MAETANI Yoji Kyoto Univ., Graduate School of Medicine, Assistant Professor, 医学研究科, 助手 (30324619)
MATSUMOTO Shinichi Kyoto Univ., Graduate School of Medicine, Assistant Professor, 医学研究科, 助手 (70359834)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Radiation / Clinical / Diagnosis Imaging / Transplantation / Diabetes melltius / MRスペクトロスコピー / 膵臓 |
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| Research Abstract |
Proton MR spectroscopy of the pancreas was performed at 3.0 T (Magnetom Trio ; Siemens). Initially normal adult volunteers underwent single-voxel PRESS with water suppression for optimization of imaging parameters on proton MR spectroscopy of the pancreas. Optimal imaging parameters as follows: repetition time, 1500 msec ; effective echo time, 30 msec ; flip angle, 90 degree; readout bandwidth, 1200 Hz/Px; image resolution, 1.5 x 1.5 x 1.5 mm; average, 12; and acquisition time, 24 seconds. Next proton MR spectroscopy of the pancreas with optimal imaging parameters were performed in 16 normal adult volunteers. Two main peaks were observed in all volunteers : (i)situated 1.3 ppm ±0.2 ppm corresponds to the well-known fat, and (ii)situated 5.1 ppm ±0.2 ppm corresponds to the well-known cholesterol. Moreover, a third peak was exhibited : (iii)situated 3.2 ppm ± 0.2 ppm corresponds to the well-known choline, while this peak was obtained in 4 of 16 volunteers. This is probably caused by insufficient optimization of hardware and software. And proton MR spectroscopy with above optimal imaging parameters was performed in 10 patients with hepatocellular carcinoma. The peak corresponds to the choline was observed in all patients. The higher ratios (choline / fat) were observed within tumor in 2 patients with poorly-differented hepatocellular carcinoma compared with in 8 patients with well-differented or moderate-differented hepatocellular carcinoma. Proton MR spectroscopy at 3.0 T might have the potential to evaluate the pathological grade of hepatocellular carcinoma.
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