The bystander effect observed in boron neutron capture therapy
| Project/Area Number |
17591266
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
KINASHI Yuko Kyoto University, Research Reactor Institute, Assistant Professor (80252534)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,730,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | micronucleus / lymphocyte / boron neutron capture therapy / acute radiation effect / α粒子 / 突然変異 / ホウ素化合物 |
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| Research Abstract |
Evaluation of micronucleus induction in lymphocytes of patients following Boron-Neutron-Capture-Therapy
(1) A comparison with thyroid cancer patients treated with radioiodine
This study evaluated micronuclei induction in peripheral T-lymphocytes after BNCT (boron neutron capture therapy) irradiation of brain tumor and head-and-neck cancer patients. In all of these patients, the micronucleus frequency increased after BNCT; the number of micronuclei per 1000 binucleated T-lymphocytes after BNCT increased by 33.0±12.2 for brain tumor patients and 22.8±10.3 for head-and-neck cancer patients. In comparison to 14 thyroid cancer patients administered radioiodine (3.3-5.6 GBq) treatment, the frequency of micronuclei after internal radioiodine therapy increased to 105.0±30.5 per 1000 binucleated T-lymphocytes for thyroid cancer patients; thereafter, the increased micronucleus frequency of BNCT patients was less than one-third that seen for thyroid cancer patients after radioiodine treatment
(2) A comparison with X-ray radiotherapy
The evidence of acute radiation effect was studied based on a questionnaire answered by the chief physician. In an in-vitro neutron radiation study, we observed standard dose-response model induction and calculated the maximal biological dose estimation as 0.24 Gy-eq for head and neck tumor patients and 0.20 Gy-eq for brain tumor patients. The total body radiation dose obtained by biological estimation using the micronucleus assay correlated with the total effective dose of BNCT obtained by thermal neutron fluence and TLD estimation. The increased micronucleus frequency in BNCT patients was less than one-third of that in malignant tumor patients after X-ray radiotherapy.
These findings (1 and 2) demonstrate the usefulness of BNCT for selective high-LET radiotherapy, in association with a low irradiation effect of cytological radiation damage after BNCT, which provides a high tumor target dose for each cancer patient.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Radiobiologic significance of response of intratumor quiescent cells to accelated carbon ion beams compared with gamma-rays and reactor neutron beams2008
Author(s)
S. Masunaga, K Ando, A Uzawa, R Hirayama, Y Furusawa, S Koike, Y Sakurai, K. Nagata, M. Suzuki, G. Kashino, Y. Kinashi, H Tanaka, A Maruhashi and K. Ono
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Journal Title
International Journal of Radiation Oncology, Biology, Physics 70
Pages: 221-228
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Journal Article] Biological dosimetry using micronucleus assay of lymphocytes for BNCT patients2008
Author(s)
Y., Kinashi, Y., Sakurai, S., Masunaga, M., Suzuki, K., Nagata, K., Ono
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Journal Title
J.Jpn.Soc.Ther.Radiol.Oncol 20
Pages: 23-28
NAID
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Radiobiologic significance of response of intratumor quiescent cells to accelated carbon ion beams compared with gamma-rays and reactor neutron beams2008
Author(s)
S., Masunaga, K., Ando, A., Uzawa, R., Hirayama, Y., Furusawa, S., Koike, Y., Sakurai, K., Nagata, M., Suzuki, G., Kashino, Y., Kinashi, H., Tanaka, A., Maruhashi, K.,Ono
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Journal Title
International Journal of Radiation Oncology, Biology, Physics 70
Pages: 221-228
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Effective suppression of bystander effects by DMSO treatment of irradiated CHO cells.2007
Author(s)
Kashino G, Prise KM, Suzuki K, Matsuda N, Kodama S, Suzuki M, Nagata K, Kinashi Y, Masunaga S, Ono K, Watanabe M.
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Journal Title
Journal of Radiation Research 48
Pages: 327-333
NAID
Description
「研究成果報告書概要(和文)」より
Related Report
Peer Reviewed
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[Journal Article] The bystandar effect observed in boron neutron capture therapy : a study of the induction of mutations in the HPRT locus2007
Author(s)
Y., Kinashi, S., Masunaga, M., Suzuki, K., Nagata, S., Takahashi, K., Ono
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Journal Title
International Journal of Radiation Oncology, Biology, Physics 68
Pages: 508-514
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Evaluation of micronucleus induction in lymphocytes of patients following Boron-Neutron-Capture-Therapy : A comparison with thyroid cancer patients treated with radioiodine2007
Author(s)
Y., Kinashi, S., Masunaga, Y., Sakurai, M., Suzuki, K., Nagata, K., Ono
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Journal Title
Journal of Radiation Research 48
Pages: 197-204
NAID
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Dependency of rapair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treated in vivo, with reference to the effect on intratumor quescent cell popuration2007
Author(s)
S., Masunaga, A., Takahashi, K., Ohnishi, K., Nagata, M., Suzuki, G., Kashino, Y., Kinashi, T., Ohnishi, K., Ono
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Journal Title
Oncology Reports 18
Pages: 1589-1596
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Inhibition of repair if radiation-induced damage by mild temperature hyperthermia, reffering to the effect on quiescent cell popurations2007
Author(s)
S., Masunaga, K., Nagata, M., Suzuki, G., Kashino, Y., Kinashi, H., Tanaka, A., Maruhashi, K., Ono
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Journal Title
Radiation Medicine 25
Pages: 417-425
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Effective suppression of bystander effects by DMSO treatment of irradiated CHO cells2007
Author(s)
Kashino, G., Prise KM., Suzuki, K., Matsuda, N., Kodama, S., Suzuki, M., Nagata, K., Kinashi, Y., Masunaga, S., Ono, K., Watanabe, M
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Journal Title
Journal of Radiation Research 48
Pages: 327-333
NAID
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] First attempt of boron neutron capture therapy (BNCT) for hepatocellular carcinoma A preliminary experimental study of boron neutron capture therapy for malignant tumors sreading in thoracic cavity2007
Author(s)
M., Suzuki, Y., Sakurai, S., Hagiwara, S., Masunaga, Y., Kinashi, K., Nagata, A., Maruhashi, M., Kudo, K., Ono
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Journal Title
Japanese Journal of Clinical Oncology 37
Pages: 376-381
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] The potential of transferrin-pendant-type polyethyleneglycol liposomes encapsulation decahydrodecaborate-B-10 (GB-10)as B-10-carriers for boron neutron capture therapy2006
Author(s)
SI.Masunaga, S.Kataoka, M.Maruyama, D.Nigg, Y.Sakurai, K.Nagata, M.Suzuki, Y.Kinashi, A.Maryhashi, K.Ono
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Journal Title
International Journal of Radiation Oncology, Biology, Physics 66・5
Pages: 1515-1522
Related Report
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[Journal Article] Impact of intra-arterial administration of boron ompounds on dose-volume histgrams in boron neutron capture therapy for recurrent head-and-neck tumors2006
Author(s)
M.Suzuki, Y.Sakurai, K.Nagata, Y.Kinashi, S.Masunaga, K.Ono, A.Maruhashi, I.Kato, N.Fuwa, J.Hiratsuka, Y.Imahori
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Journal Title
International Journal of Radiation Oncology, Biology, Physics 66・5
Pages: 1523-1527
Related Report
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[Journal Article] The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B conjugate compound, TX-2100, for boron neutron capture therapy
Author(s)
Shin-ichiro Masunaga, Hideko Nagasawa, Yoshinori Sakurai, Yoshihiro Uto, Hitoshi Hori, Kenji Nagata, Minoru Suzuki, Akira Maruhashi, Yuko Kinashi, Koji Ono
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Journal Title
International Journal of Hyperthermia (in press)(未定)
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