| Project/Area Number |
17591268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
OKAMOTO Yoshiaki Kobe University, University Hospital, Radiology, Lecturer, 医学部附属病院, 講師 (20362791)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMURA Kazuro Kobe University Graduate School of Medicine, Radiology, Professor, 大学院・医学系研究科, 教授 (00136384)
NIBU Kenichi Kobe University, Graduate School of Medicine, Head and Neck surgery, Professor, 大学院・医学系研究科, 教授 (20251283)
SASAKI Ryohei Kobe University Graduate School of Medicine, Radiology, Associate Professor, 大学院・医学系研究科, 学術推進研究員 (30346267)
KAWASAKI Ryota Kobe University Hospital, Radiology, Assistant Professor, 医学部附属病院, 助手 (00362781)
OTA Yosuke Kobe University, University Hospital, Radiology, Fellow, 医学部附属病院, 医員 (90397810)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | AKT / NF-KappaB / Radiosensitivity / Radioresistance / p53 |
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| Research Abstract |
Significance of AKT in the radioresistant mechanism has not been clarified. In this study, Free radical mediated AKT activation and NF-kappa B activation were closely related to the radioresistance in both normal and malignant cells. Especially, Pelicano and Sasaki have reported that mitochondrial respiratory function communicated with AKT activation through free radical, and the communication led to the invasiveness of the tumor or chemosensitivity.
Demizu and Okamoto have reported that effectiveness of cisplatin-based concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma, and clinical outcomes of the treatment as a preliminary report. In the present study, we have found there are certain percentage of patients who experienced their poor outcomes. Moreover, we are now investigating that the relationships between resistance to the anticancer treatment and the AKT activation, as well as p53, NF-kappa B.
Ejima and Okamoto have reported that outcomes of MALT lymphoma of the orbita in the journal of Radiotherapy and Oncology. In the study, prognostic factors and adverse effects were clarified from the analysis, in the same time. For this disease, prognostic factors have not been determined. Therefore, candidates for molecular mechanisms of radioresistance, such as AKT, p53 BCL-10, were also assessed. Those results were now preparing for another submission.
Thus, the significance of AKT in the radioresistant mechanism were investigated in the multiple situation. In vitro study, and clinical investigation were performed, leading to the fact that AKT was one of the important candidate for molecular mechanisms of intracellular radioresistance.
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