| Project/Area Number |
17591271
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Okayama University |
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Principal Investigator |
KANAZAWA Susumu Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Professor, 大学院医歯薬学総合研究科, 教授 (20243511)
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| Co-Investigator(Kenkyū-buntansha) |
MIMURA Hidefumi University Hospital of Medical and Dentistry, Lecturer, 医学部・歯学部附属病院, 講師 (10304362)
GOBARA Hideo University Hospital of Medical and Dentistry, Research Associate, 医学部・歯学部附属病院, 助手 (10379745)
FUJIWARA Hiroaysu University Hospital of Medical and Dentistry, Research Associate, 医学部・歯学部附属病院, 助手 (70423324)
向井 敬 岡山大学, 医学部・歯学部附属病院, 助手 (70379759)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2006: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 2005: ¥3,600,000 (Direct Cost: ¥3,600,000)
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| Keywords | cancer / radiofrequency / ablation |
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| Research Abstract |
Radiofrequency (RF) ablation is a new clinical procedure which has been applied for the treatment of lung malignancies for recent years.
To improve clinical results, it is very important to enlarge the RF ablation area in the lung. One possible way to enlarge the ablation area is an injection of saline in the lung to improve RF induction. The other way is an artificial obstruction of the pulmonary artery in the ablation area to reduce the blood flow which cools the ablation area. The purpose of our study was to confirm the usefulness of these two interventions by animal experiment.
Domestic pigs and LeVeen RF electrode with 2cm in diameter and RF 2000 or 3000 Generator system (Radiotherapeutics) were used in this experiment. Living pig's lung was ablated by RF with and without 3m1 of saline injection under the same ablation algorism then the pig was scarified. Macro-and microscopic examinations showed that the volume of the ablated area with saline injection was almost twice as much as that without saline injection and more homogenous ablation was observed with saline injection.
In the next experiment, pig's lung was ablated with and without pulmonary arterial embolization with degradable starch micro-spheres (DSM) which could temporarily occlude vessels. Macro-and microscopic examinations showed that the volume of the ablated area with embolization was almost twice as much as that without embolization and the lung tissue was not injured by embolization.
This study revealed the safety and usefulness of saline injection and temporary occlusion of the pulmonary artery when we try to enlarge the ablation area in the lung by RF.
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