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Estimation of pulmonary hypertension by measurement of flow profile of pulmonary artery with CineMRI

Research Project

Project/Area Number 17591283
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionUniversity of the Ryukyus

Principal Investigator

MURAYAMA Sadayuki  University of the Ryukyus, Department of Radiology, Professor (60239548)

Co-Investigator(Kenkyū-buntansha) KAKINOHANA Yasumasa  University of the Ryukyus, Department of Radiology, Assistant (20185713)
IIDA Gyo  Hospital of University of the Ryukyus, Department of Radiology, Assistant (60404571)
AKAMINE Tamaki  University of the Ryukyus, Department of Radiology, Assistant (50325841)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,570,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordscineMRI / pulmonary artery blood flow / pulmonary fibrosis / interstisial pneumonia / pulmonary hypertention / MRA / 肺動脈流速 / 肺高血 / cine MRA
Research Abstract

We measured pulmonary blood flow with phase contrast MRI for 20 volunteers and evaluated precision and reproducible of two slice positions, that is, perpendicular to pulmonary trunck and not, We detected a method to determine the slice which was perpendicular to a pulmonary artery, and reported that precision and reproducibility is higher with perpendicular slices
Based on this preliminary study, we examined whether pulmonary artery blood flow and other data were useful in an evaluation of the pulmonary hypertension. The subjects were ten patients with pulmonary fibrosis (they were thought that pulmonary arterial pressure was elevated) and ten healthy people. We measured pulmonary artery blood flow and calculated an index of some pulmonary hypertension; acceleration time (AT), acceleration volumes (AV), ratios M to AV (M: maximal change in flow rate during ejection), distensibility (Dis), average flow (Aveflo) and compared healty persons and the patient with pulmonary fibrosis. Respiratory function test was performed to the patients and evaluated the correlation with the indices. Almost all indices were significantly different between patients and volunteers. ROC analysis showed high capability of indices to discriminate patients from healthy volunteers. These results show that phase contrast MRI is a useful technique to evaluate elevation of the pulmonary arterial pressure. Compared indices with respiratory function test results, Dis, Aveflo showed a good correlation with severity of the pulmonary fibrosis. This suggests that these indexes reflected the distal pulmonary change, i. e. fibrosis, better than pulmonary arterial pressure. Additional investigations are necessary to confirm these results

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (8 results)

All 2009 2008 2007

All Journal Article (2 results) Presentation (6 results)

  • [Journal Article] cineMRIを用いた肺動脈流速測定による二次性肺高血圧の評価法の確立2007

    • Author(s)
      宮城英樹, 鮎川雄一郎, 村山貞之
    • Journal Title

      インナービジョン 22(7)

      Pages: 47-47

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Estimation of pulmonary hypertension by measurement of flow profile of pulmonary artery with Cine MRI2007

    • Author(s)
      Miyagi H, Ayukawa Y, Murayama S
    • Journal Title

      Innervision 22(7)

      Pages: 49-49

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The 1^<st> Japanese Society of Pulmonary Functional Imaging 2009/1/30 Kyoto2009

    • Author(s)
      Ayukawa Y
    • Organizer
      The 68th Annual Meeting of Japan Radiological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2009-04-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] MRI phase contrat法による肺線維症患者の肺高血圧評価2008

    • Author(s)
      鮎川雄一郎
    • Organizer
      第36回日本磁気共鳴医学会
    • Place of Presentation
      旭川市
    • Year and Date
      2008-09-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Estimation of pulmonary artery pressure in patients with pulmonary fibrosis by phase contrast MRI2008

    • Author(s)
      Ayukawa Y
    • Organizer
      The 36^<th> Japan Society for Magnetic Resonance in Medicine
    • Place of Presentation
      Asahikawa
    • Year and Date
      2008-09-12
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] MRI phase contrat法による肺線維症患者の肺高血圧評価2008

    • Author(s)
      鮎川雄一郎
    • Organizer
      第68回日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-04-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Phase contrast MRIを用いた肺動脈血流評価のスライス面による精度、再現性の検討2007

    • Author(s)
      鮎川雄一郎
    • Organizer
      第66回日本医学放射線学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2007-04-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Estimation of precision and reproducibility of pulmonary artery flow measurement by slice positions with phase contrast MRI2007

    • Author(s)
      Ayukawa Y
    • Organizer
      The 66th Annual Meeting of Japan Radiological Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-04-14
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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