| Project/Area Number |
17591297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
MATOBA Munetaka Kanazawa Medical University, Department of medicine, assistant professor, 医学部, 助教授 (90288308)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOTA Hajime Kanazawa Medical University, Department of medicine, instructor, 医学部, 講師 (30182695)
OOGUCH Manabu Kanazawa Medical University, Department of medicine, instructor, 医学部, 講師 (10176852)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | irradiation / animal study / VX2 carcinoma / MRI / MR spectroscopy / 動物実験 / 腫瘍 / 放射線治療 / 化学療法 |
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| Research Abstract |
We assessed the role of the high-resolution MRI and ^1H-MRS evaluating the therapieutic effect of chemotherapy and radiation therapy for VX2 carcinoma in rabbits. The rabbits with VX2 carcinoma in the thigh were underwent MRI and ^1H-MRS at before, 3 days, 1 week, and 2 weeks after 30Gy irradiation and one shot chemotherapy. After taking postirradiation MRI and ^1H-MRS, rabbits were killed for histopathologic examination at each time interval.
The high-resolution MRI findings were correlated with the histopathological findings, however, the early stage of necrosis of tumor was not able to evaluate using the high-resolution MRI. On ^1H-MRS, the ratio of lactate / creatine was elevated in the early stage of necrosis of tumor.
It was suggested that ^1H-MRS was superior to high-resolution MRI evaluating the early stage of necrosis of VX2 carcinoma post chemotherapy and radiation therapy.
The ^1H-MRS might be superior evaluating the therapieutic effects earlier.
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