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Cellular characteristics and clinical assessment of breast cancer using F-18 FDG-PET

Research Project

Project/Area Number 17591304
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKurume University

Principal Investigator

ISHIBASHI Masatoshi  Kurume University, Dept. of Medicine, Professor (20168256)

Co-Investigator(Kenkyū-buntansha) KAIDA Hayato  Kurume University, Dept of Medicine, Assistant Prof (40299425)
YAMANA Hideaki  Kurume University, Dept of Medicine, Professor (30140669)
FUJII Teruhiko  Kurume University, Dept of Medicine, Associated Professor (50199288)
HAYABUCHI Naofumi  Kurume University, Dept of Medicine, Professor (20108731)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥2,110,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥500,000 (Direct Cost: ¥500,000)
KeywordsBreast cancer / Cell proliferation / ERK MAPK / Prognosis of patients with breast cancer
Research Abstract

One hundred eighteen female patients (age range 28-91 years) with 122 lesions suspected of having breast cancer underwent fluorine-18 fluorodeoxyglucose (^<18>F-FDG) PET for preoperative staging. After the whole-body image was acquired, prone breast PET imaging was performed. The findings from both images were compared with the histopathologic results. Sensitivity, specificity, positive predictive values (PPV), negative predictive values (NPV), and accuracy were used to compare the diagnostic accuracy of prone breast PET images with that of whole-body PET images. Sensitivity, specificity, PPV, NPV, and accuracy of whole-body PET images were 83%, 50%, 97%, 17%, and 80%, and for prone breast PET images were 95%, 50%, 96%, 43%, and 93%. Ten of 114 breast cancerous lesions (8.8%) were detected on prone breast PET images alone. There was statistical difference between the sensitivity, accuracy, and NPV of prone breast PET images and, those of whole-body PET images (P < 0.0001 for sensitivity and accuracy, and P < 0.0009 for NPV). In conclusion, our data regarding the 122 lesions suspected of breast cancer with regard to the usefulness of prone breast PET imaging indicate that prone breast PET images are effective in detecting breast cancer.
With respect to cell proliferation in breast cancer, we evaluated the relationship between ERK MAPK and SUVmax obtained by FDG-PET. Unfortunately, there was no correlation between ERK MAPK obtained by immunohistopathology and SUVmax. Our resultant data addressed that cell proliferation in breast cancer is need to choose the future course in the FDG-PET study.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (11 results)

All 2008 2006

All Journal Article (8 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Improved detection of breast cancer on FDG-PET cancer screeing breast poitioning device2008

    • Author(s)
      Kaida H, Ishibashi M, et. al.
    • Journal Title

      Ann Nucl Med 22

      Pages: 95-101

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Improved breast cancer detection of prone breast FDG-PET in 118 patients2008

    • Author(s)
      Kaida H, Ishibashi M, et. al.
    • Journal Title

      Nucl Med Commun

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Improved detection of breast cancer on FDG-PET cancer screening breast positioning device2008

    • Author(s)
      Kaida H, Ishibashi M, et. al.
    • Journal Title

      Ann Nuci 22

      Pages: 95-101

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Improved breast cancer detection of prone breast FDG-PET ml 18 patients.2008

    • Author(s)
      Kaida H, Ishibashi M, et. al.
    • Journal Title

      Nuci Med Commun (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Expression of ErbB2/HER2 and Expression of ErbB2/HER2 and Y-box binding protein-i in human breast cancers2008

    • Author(s)
      Fujii T, Yamana H, et. al.
    • Journal Title

      Cancer Res (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clinicopathological study of invasive ductal carcinoma with large central acellular zone: Special reference to magnetic resonance imaging findings.2008

    • Author(s)
      Yamaguchi R, Fujii T, et. al.
    • Journal Title

      Pathol Int 58

      Pages: 26-30

    • NAID

      10027375400

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Preclinical ,clinical studies of novel drugs for breast cancer Preclinical, clinical studies of novel drugs for breast cancer2008

    • Author(s)
      Fujii T, et. al.
    • Journal Title

      Curr Med Chem (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] 17b-Estradiol induces down-regulation of Cap43/NDRG1/Drg-l, a putative differentiation-related ,metastasis suppressor gene, in human breast cancer cells.2006

    • Author(s)
      Fotovati A, Fujii T, et. al.
    • Journal Title

      Clin Cancer Res 12

      Pages: 3010-3018

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evaluation of FDG-PET in paatients with bxaest cancer using the 〓 device2008

    • Author(s)
      Kaida H, Whibashi M, et. al.
    • Organizer
      欧州核医学公
    • Place of Presentation
      アテネ
    • Related Report
      2007 Annual Research Report
  • [Presentation] Evaluation of FDG-PET in patients with braest cancer using the novel device2006

    • Author(s)
      Kaida H, Ishibashi M, et. al.
    • Organizer
      欧州核医学会
    • Place of Presentation
      アテネ
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Evaluation of FDG-PET in patients with breast cancer using the novel device2006

    • Author(s)
      Hayato Kaida, Masatoshi Ishibashi, et. al.
    • Organizer
      Annual Congress of the European Association of Nuclear Medicine,Megaron International Conference Center
    • Place of Presentation
      Athes, Greece
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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