| Project/Area Number |
17591307
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gunma Prefectural College of Health Sciences |
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Principal Investigator |
KASHIKURA Kenichi Gunma Prefectural College of Health Sciences, Department of Radiological Technology, Professor (30369368)
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| Co-Investigator(Kenkyū-buntansha) |
OBATA Takayuki National Institute of Radiological Sciences, Molecular Imaging Center, Researcher (00285107)
YONEKURA Yoshiharu National Institute of Radiological Sciences, President (60135572)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Cerebral Nerve / Physiology / Neuroscience |
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| Research Abstract |
We have developed a simultaneous measurement system using functional magnetic resonance imaging (fMRI) and near-infrared spectroscopy (NIRS) technique. Twenty-two normal volunteers aged 21 to 43 were studied with a 3T MRI system (GEYMS Signa Horizon LX) and an optical imaging system (Hitachi ETG-100). Optical cable-bundle was extended to the MR head-coil to set up the simultaneous acquisition system. Various photic patterns and durations were used for the visual activations. The temporal characteristics of blood oxygenation level-dependent (BOLD) responses to brief visual stimulation of the human primary visual cortex (V1) were investigated using an event-related functional magnetic resonance imaging (ER-fMRI) technique. The magnitude and extent of the BOLD response were examined by changing the stimulus duration of a reversing checkerboard between 1 to 6 secs. In addition, the relationship between measured and predicted BOLD responses was evaluated. Results show that the peak height and the area above the baseline increased linearly as a function of stimulus duration. Retinotopic and event-related studies showed that the localization and linearity of the responses with these two systems were nearly identical. The fMRI contrast (BOLD) uses deoxyhemoglobin information, and NIRS uses both oxyhemoglobin and deoxyhemoglobin dynamics (the sum of these are named total hemoglobin, related to cerebral blood volume). Simultaneous measurement system provides and integrates the spatial and temporal dynamics with respect to the brain physiological parameters (e.g., CBF, CBV, and CMRO2).
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