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Second cancer after radiotherapy for malignant neoplasm: Epidemiological and molecular biological analysis.

Research Project

Project/Area Number 17591310
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

OHNO Tatsuya  National Institute of Radiological Sciences, Research Center for Charged Particle Therapy, Senior stuff, 重粒子医科学センター病院, 医長 (10344061)

Co-Investigator(Kenkyū-buntansha) SHIMADA Yoshiya  National Institute of Radiological Sciences, Research Center for Radiation Safety, Proiect leader, 放射線防護研究センター, グループリーダー (10201550)
KAKINUMA Shizuko  National Institute of Radiological Sciences, Research Center for Radiation Safety, Senior stuff, 放射線防護研究センター, チームリーダー (20392219)
KATO Shingo  National Institute of Radiological Sciences, Research Center for Charged Particle Therapy, Head, 重粒子医科学センター病院, 室長 (00370875)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsMalignant neplasm / Radiotherapy / Second cancer
Research Abstract

Occurrence of a second cancer is the most serious event among long-term survivors after radiotherapy (RT). The purpose of this study was to evaluate the risk of second cancers after cervical cancer treated with RT. We reviewed 2,167 patients with uterine cervical cancer undergoing RT between 1961 and 1986 at the National Institute of Radiological Sciences. Among them, 1,702 (79%) patients were treated with RT-alone group and 465 (21%) received postoperative RT. Their mean age was 60 years in the RT alone and 49 years in the postoperative RT group. Intracavitary brachytherapy was performed with high-dose rate source (82%) or low-dose rate source (18%) for RT alone. Relative risk (RR) of second cancer was calculated using the Japanese disease expectancy table. In addition, RR of second cancer was calculated by age at RT and the post-RT duration of follow-up. The total number of person-years of follow-up was 25,771, with 60 patients being lost to follow-up. Among 2,167 patients, 1,063 patients (49%) survived more than 10 years. Second cancers developed in 210 patients, which represented a significant increase in risk compared with a comparable normal population (RR = 1.24, 95%CI = 1.08-1.42). RR of developing a second cancer was significantly elevated for patients younger than 60 years at RT (RR = 1.33, 95%CI = 1.10-1.61) and for patients with post-RT follow-up between 5 and 15 years (RR = 1.31, 95%CI = 1.06-1.62). The estimated cumulative probability for development of a second cancer was 6.7% at 10 years, 15.6% at 20 years, and 23.8% at 30 years. Significant increased risk of second cancers was observed among long-term survivors after RT for cervical cancer. RR differed by age at RT and interval of follow-up after RT, helping us to identify a high-risk population for the development of second cancers.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (40 results)

All 2007 2006 2005

All Journal Article (38 results) Book (2 results)

  • [Journal Article] Long-term survival and risk of second cancers after radiotherapy for cervical cancer2007

    • Author(s)
      Ohno T, Kato S, Sato S, Fukuhisa K, Nakano T, Tsujii H, Arai T
    • Journal Title

      Int J Radiat Oncol Biol Phys (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ikaros is a mutational target for lymphomagenesis in MIh1-deficient mice.2007

    • Author(s)
      Kakinuma S, Kodama Y, Amasaki Y, Yi S, Tokairin Y, Arai M, Nishimura M, Monobe M, Kojima S, Shimada Y
    • Journal Title

      Oncogene 26(20)

      Pages: 2945-2949

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Late rectal complications evaluated by CT-based dose calculations in patients with cervical carcinoma undergoing high-dose rate brachytherapy2007

    • Author(s)
      Noda S, Ohno T, Kato S, Ishii T, Saito O, Wakatsuki M, Tamaki T, Watanabe K, Nakano T, Tsujii H
    • Journal Title

      Int J Radiat Oncol Biol Phys (In prerss)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Long-term survival and risk of second cancers after radiotherapy for cervical cancer2007

    • Author(s)
      Ohno T, Kato S, Sato S, Fukuhisa K, Nakano T, Tsujii H, Arai T
    • Journal Title

      Int J Radiat Oncol Biol Phys (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Ikaros is a mutational target for lymphomagenesis in Mlh1-deficient mice.2007

    • Author(s)
      Kakinuma S, Kodama Y, Amasaki Y, Yi S, Tokairin Y, Arai M, Nishimura M, Monobe, M, Kojima S, Shimada Y.
    • Journal Title

      Oncogene 26(20)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Late rectal complications evaluated by CT-based dose calculations in patients with cervical carcinoma undergoing high-dose rate brachytherapy2007

    • Author(s)
      Noda S, Ohno T, Kato S, Ishii T, Saito O, Wakatsuki M, Tamaki T, Watanabe K, Nakano T, Tsujii H
    • Journal Title

      Int J Radiat Oncol Biol Phys (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Gynecologic cancer. Thomas F. Delaney (Ed.). Proton and Heavier Charged Particle Radiotherapy2007

    • Author(s)
      Nakano T, Kato S, Ohno T, Suzuki Y
    • Journal Title

      Lippincott. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Long-term survival and of second cancers after radiotherapy for cervical cancer2007

    • Author(s)
      Ohno T, Kato S, Sato S, Fukuhisa K, Nakano T, Tsujii H, Arai T
    • Journal Title

      Int J Radiat Oncol Boil Phys (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Carbon ion radiotherapy for vaginal melanoma : a case report.2007

    • Author(s)
      Ohno T, Kato S, Sasaki E, Mizutani K, Tsujii H.
    • Journal Title

      Int J Gynecol Cancer. (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ikaros is a mutational target for lymphomagenesis in Mlhl-deficient mice.2007

    • Author(s)
      Kakinuma S, Kodama Y, Amasaki Y, Yi S, Tokairin Y, Arai M, Nishimura M, Monobe M, Kojima S, Shimada Y.
    • Journal Title

      Oncogene 26(20)

      Pages: 2945-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Late rectal complications evaluated by CT-based dose calculations in patients with cervical carcinoma undergoing high-dose rate brachytherapy2007

    • Author(s)
      Noda S, Ohno T, Kato S, Ishii T, Saito O, Wakatsuki M, Tamaki T, Watanabe K, Nakano T, Tsujii H
    • Journal Title

      Int J Radiat Oncol Biol Phys (In press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Risk of second cancers after radiotherapy for cervical cancer2006

    • Author(s)
      Ohno T, Kakinuma S, Kato S, Tsujii H, Shimada Y
    • Journal Title

      Expert Review of Anticancer Therapy 6・1

      Pages: 49-57

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The PCC assay can be used to predict radiosensitivity in biopsy cultures irradiated with different types of radiation.2006

    • Author(s)
      Suzuki M, Tsuruoka C, Nakano T, Ohno T, Furusawa Y, Okayasu R
    • Journal Title

      Oncol Rep. 16(6)

      Pages: 1293-1299

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Investigation of new cytogenetic biomarkers specific to high-LET radiation using in vivo and in vitro exposed human lymphocytes.2006

    • Author(s)
      Kanda R, Minamihisamatsu M, Tsuji S, Ohmachi Y, Hiraoka T, Shimada Y, Ogiu T, Ohno T, Hayata I
    • Journal Title

      Int J Radiat Biol. 82(7)

      Pages: 483-491

    • NAID

      130006999448

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cyclooxygenase-2 Impairs treatment Effects of Radiotherapy for Cervical Cancer by Inhibition of Radiation-Induced Apoptosis.2006

    • Author(s)
      Ishikawa H, Ohno T, Kato S, Wakatuki M, Iwakawa M, Oota T, Imai T, Mitsuhashi N, Noda S, Nakano T, Tsujii H
    • Journal Title

      Int J Radiat Oncol Biol Phys. 66(5)

      Pages: 1347-1355

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The Effects of Carbon Ion Irradiation Revealed by Excised Perforated Intestines as a Late Morbidity for Uterine Cancer Treatment.2006

    • Author(s)
      Matsushita K, Ochiai T, Shimada H, Kato S, Ohno T, Nikaido T, Yamada S, Okazumi S, Matsubara H, Takayama W, Ishikura H, Tsuji H.
    • Journal Title

      Surg Today. 36(8)

      Pages: 692-700

    • NAID

      10018169533

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice.2006

    • Author(s)
      Taniguchi K, Kakinuma S, Tokairin Y, Arai M, Kohno H, Wakabayashi K, Imaoka T, Ito E, Koike M, Uetake H, Nishimura M, Yamauchi K, Sugihara K, Shimada Y.
    • Journal Title

      Oncology. 71(1-2)

      Pages: 124-30

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Incidencd and temporal pattern of anorexia, diarrhea, weightloss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin : comparison with radiation therapy alone.2006

    • Author(s)
      Ohno T, Kato S, Wakatuki M, Noda S, Murakami C, Nakamura M, Tsujii H
    • Journal Title

      Gynecologic Oncology 103

      Pages: 94-99

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Carbon beam therapy overcomes hypoxia-originating radiation-resistant nature of uterine cervical cancer originating from hypoxia2006

    • Author(s)
      Nakano T, Suzuki Y, Ohno T, Kato S, Suzuki M, Morita S, Sato S, Oka K, Tsujii H
    • Journal Title

      Clinical Cancer Research 12(7)

      Pages: 2185-2190

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] マイクロアレイによる放射線治療効果予測2006

    • Author(s)
      石川 仁, 大野 達也, 岩川 眞由美, 若月 優, 加藤 真吾, 中野 隆史, 辻井 博彦, 今井 高志
    • Journal Title

      癌の臨床 52(1)

      Pages: 53-60

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 婦人科領域における放射線治療の展望2006

    • Author(s)
      加藤 真吾, 大野 達也, 辻井 博彦
    • Journal Title

      第39回日本婦人科腫瘍学会記録 24(3)

      Pages: 379-384

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Risk of second cancers after radiotherapy for cervical cancer2006

    • Author(s)
      Ohno T, Kakinuma S, Kato S, Tsujii H, Shimada Y
    • Journal Title

      Expert Review of Anticancer Therapy 6

      Pages: 49-57

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The PCC assay can be used to predict radiosensitivity in biopsy cultures irradiated with different types of radiation2006

    • Author(s)
      Suzuki M, Tsuruoka C, Nakano T, Ohno T, Furusawa Y, Okayasu R.
    • Journal Title

      Oncol Rep 16(6)

      Pages: 1293-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Investigation of new cytogenetic biomarkers specific to high-LET radiation using in vivo and in vitro exposed human lymphocytes.2006

    • Author(s)
      Kanda R, Minamihisamatsu M, Tsuji S, Ohmachi Y, Hiraoka T, Shimada Y, Ogiu T, Ohno T, Hayata I
    • Journal Title

      I Int J Radiat Biol. 82(7)

      Pages: 483-91

    • NAID

      130006999448

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Cyclooxygenase-2 Impairs treatment Effects of Radiotherapy for Cervical Cancer by Inhibition of Radiation-Induced Apoptosis.2006

    • Author(s)
      Ishikawa H, Ohno T, Kato S, Wakatuki M, Iwakawa M, Oota T, Imai T, Mitsuhashi N, Noda S, Nakano T, Tsujii H.
    • Journal Title

      Int J Radiat Oncol Biol Phys. 66(5)

      Pages: 1347-1355

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice.2006

    • Author(s)
      Taniguchi K, Kakinuma S, Tokairin Y, Arai M, Kohno H, Wakabayashi K, Imaoka T, Ito E, Koike M, Uetake H, Nishimura M, Yamauchi K, Sugihara K, Shimada Y.
    • Journal Title

      Oncology 71(1-2)

      Pages: 124-30

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Incidence and temporal pattern of anorexia, diarrhea, weight loss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin : comparison with radiation therapy alone.2006

    • Author(s)
      Ohno T, Kato S, Wakatuki M, Noda S, Murakami C, Nakamura M, Tsujii H
    • Journal Title

      Gynecologic Oncology 103

      Pages: 94-99

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] The PCC assay can be used to predict radiosensitivity in biopsy cultures irradiated with different types of radiation.2006

    • Author(s)
      Suzuki M, Tsuruoka C, Nakano T, Ohno T, Furusawa Y, Okayasu R.
    • Journal Title

      Oncol Rep. 16(6)

      Pages: 1293-9

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Investigation of new cytogenetic biomarkers specific to high-LET radiation using in vivo and in vitro exposed human lymphocytes.2006

    • Author(s)
      Kanda R, Minamihisamatsu M, Tuji S, Ohmachi Y, Hiraoka T, Shimada Y, Ogiu T, Ohno T, Hayata I
    • Journal Title

      Int J Radiat Biol. 82(7)

      Pages: 483-91

    • NAID

      130006999448

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mild inflammation accelerates colon carcinogenesis in Mlhl-deficient mice.2006

    • Author(s)
      Taniguchi K, Kakinuma S, Tokairin Y, Arai M, Kohno H, Wakabayashi K, Imaoka T, Ito E, Koike M, Uetake H, Nishimura M, Yamauchi K, Sugihara K, Shimada Y.
    • Journal Title

      Oncology. 71(1-2)

      Pages: 124-30

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Risk of second cancers after radiotherapy for cervical cancer2006

    • Author(s)
      Tatsuya Ohno, Shizuko Kakinuma, Shingo Kato, Hirohiko Tsujii, Yoshiya Shimada
    • Journal Title

      Expert Review of Anticancer Therapy 6・1

      Pages: 49-57

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Incidence and temporal pattern of anorexia, diarrhea, weight loss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin : comparison with radiation therapy alone.2006

    • Author(s)
      Tatsuya Ohno, Shingo Kato, Masaru Wakatuki, Shinei Noda, Chiemi Murakami, Misako Nakamura, Hirohiko Tsujii
    • Journal Title

      Gynecologic Oncology (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Carbon beam therapy overcomes hypoxia-originating radiation-resistant nature of uterine cervical cancer.2006

    • Author(s)
      Takashi Nakano, Yoshiyuki Suzuki, Tatsuya Ohno, Shingo Kato, Michiya Suzuki, Shinroku Morita, Shinichirou Satou, Kuniyuki Oka, Hirohiko Tsujii
    • Journal Title

      Clinical Cancer Research (In press)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Oxygenated and reoxvgenated tumors show better local control in radiation therapy for cervical cancer.2006

    • Author(s)
      Yoshiyuki Suzuki, Takashi Nakano, Tatsuya Ohno, Shingo Kato, Yuzuru Niibe, Shinroku Morita, Hirohiko Tsujii
    • Journal Title

      International Journal of Gynecological Cancer 16・1

      Pages: 306-311

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Histopathological radiation effect and MIB-1 expression in cervical cancer : comparison of early response by radiotherapy with or without cisplatin2005

    • Author(s)
      Kurnia Lin, Tatsuya Ohno, Shingo Kato, Hidefumi Ezawa, Junko Noguchi, Hirohiko Tsujii
    • Journal Title

      Austral-Asian Journal of Cancer 4・4

      Pages: 201-204

    • Related Report
      2005 Annual Research Report
  • [Journal Article] DNA repair capacity measured by high throughput alkaline comet assays in EBV-transformed cell lines and peripheral blood cells from cancer patients and healthy volunteers2005

    • Author(s)
      Mayumi Iwakawa, Miyako Gotou, Shuhei Noda, Masashi Sagara, Shigeru Yamada, Naohito Yamamoto, Yoshihiro Kawakami, Yoshifumi Matsui, Yukimasa Miyazawa, Hideya Yamazaki, Hiroshi Tujii, Tatsuya Ohno, Junetsu Mizoe, Hirohiko Tsujii, Takashi Imai
    • Journal Title

      Mutation Research 588・12

      Pages: 1-6

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Frequent retention of heterozygosity for point mutations in p53 and lkaros in N-etyl-N-nitrosourea-induced mouse thymic lymphomas.2005

    • Author(s)
      Shizuko Kakinuma, Mayumi Nishimura, Ayumi Kubo, Junya Nagai, Yoshiko Amasaki, Hideyuki Majima^*, Toshihiko Sado, Yoshiya Shimada
    • Journal Title

      Mutation Research 588・12

      Pages: 1-6

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Phosphorous-31 magnetic resonance spectroscopy of cervical cancer using transvaginal surface coil2005

    • Author(s)
      Takuya Morimoto, Takayuki Obata, Tatsuya Ohno, Yoshiyuki Suzuki, Hiroo Ikehira, Tetsuya Suhara, Shigeo Furukawa, Hirohiko Tsujii, Takashi Nakano
    • Journal Title

      Magnetic Resonance in Medical Sciences 4・4

      Pages: 197-201

    • NAID

      10018088286

    • Related Report
      2005 Annual Research Report
  • [Book] Gynecologic cancer (Proton and Heavier Charged Particle Radiotherapy) (Thomas F. Delaney (Ed.))2007

    • Author(s)
      Nakano T, Kato S, Ohno T, Suzuki Y
    • Publisher
      Lippincott. (In press)
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Book] Gynecologic cancer. Thomas F. Delaney(Ed.). Proton and Heavier Charged Particle Radiotherapy.2007

    • Author(s)
      Nakano T, Kato S, Ohno T, Suzuki Y
    • Publisher
      Lippincott.(In press)
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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