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Basic research of bone marrow cells for liver regeneration, fibrogenesis, and carcinogenesis

Research Project

Project/Area Number 17591316
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionAsahikawa Medical College

Principal Investigator

INAGAKI Mitsuhiro  Asahikawa Medical College, Department of Surgery, assistant professor, 医学部, 講師 (80261410)

Co-Investigator(Kenkyū-buntansha) KASAI Shinichi  Asahikawa Medical College, Dept.of Surgery, professor, 医学部, 教授 (40091566)
OGAWA Katsuhiro  Asahikawa Medical College, Dept.of Pathology, professor, 医学部, 教授 (50045514)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordsbone marrow cells / pheripheral blood cell / G-CSF / analbuminemic rat / 70% partial hepatectomy / PCR / microdissection / in situ hybridization / 凍結保存
Research Abstract

We investigated whether bone marrow cells (BMCs) of normal rats (F344) can raise albumin-producing hepatocytes in analbuminemic rat (F344a1b) livers. (J.Arikura, M.Inagaki et al. Journal of Hepatology 41;215-221,2004.X.Huiling, M. Inagaki et al. Journal of Surgical Research 122 (1) ; 75-82,2004)
In this project, we got the following results using the F344a1b.
Experiment 1 Cryopreserved BMCs can induce the growth of alb+ hepatocytes after transplantation in the F344alb liver after 70% partial hepatectomy. (M. Inagaki et al. Surgery Today 35;955-960,2005) Experiment 2 F344 rat liver nonparenchymal cell transplantation can increase the number of Alb+ hepatocytes in the liver following hematopoietic reconstitution in irradiated F344alb. (European Surgical Research 38;533-539,2006)

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (6 results)

All 2006 2005

All Journal Article (6 results)

  • [Journal Article] F344 rat liver nonparenchymal cell transplantation can increase the number of albumin-positive hepatocytes in the liver following hematopoietic reconstitution in irradiated analbuminemic rat.2006

    • Author(s)
      Y.Xia, Z.Biao, M.Inagaki, et al.
    • Journal Title

      Eur Surg Res 38

      Pages: 533-539

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] F344 rat liver nonparenchymal cell transplantation can increase the number of albumin-positive hepatocytes in the liver following hematopoietic reconstitution in irradiated analbuminemin rat.2006

    • Author(s)
      Y.Xia, Z.Biao, M.Inagaki, et al.
    • Journal Title

      Eur Sur Res 38

      Pages: 533-539

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] F344 rat liver nonparenchymal cell transplantation can increase the number of albumin-positive hepatocytes in the liver following hematopoietic reconstitution in irradiated analbuminemic rat2006

    • Author(s)
      Y.Xia, Z.Biao, M.Inagaki, et al.
    • Journal Title

      Eur Surg Res 38

      Pages: 533-533

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Albumin-producing hepatocytes derived From cryopreserved F344 rat bone marrow cells transplanted in the livers of congenic Nagase's analbuminemic rats.2005

    • Author(s)
      M.Inagaki, et al.
    • Journal Title

      Surg Today 35

      Pages: 955-960

    • NAID

      120003203345

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Albumin-producing hepatocytes derived from cryopreserved F344 rat bone marrow cells transplanted in the livers of congenic Nagase's analbuminemic rats.2005

    • Author(s)
      M.Inagaki, et al.
    • Journal Title

      Surg Today 35

      Pages: 955-960

    • NAID

      120003203345

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Albumin-producing hepatocytes derived From cryopreserved F344 rat bone marrow cells transplanted in the livers of congenic Nagase's analbuminemic rats2005

    • Author(s)
      M.Inagaki, et al.
    • Journal Title

      Surgery Today 35

      Pages: 955-960

    • NAID

      120003203345

    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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