Nutritional program using ^<13>C phenylalanine test in living donor liver transplantation
Project/Area Number |
17591328
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
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Research Institution | National Center for Child Health and Development |
Principal Investigator |
KASAHARA Mureo National Center for Child Health and Development, Head., 移植免疫診療科, 医長 (30324651)
|
Co-Investigator(Kenkyū-buntansha) |
OIKE Fumitaka Kyoto University, Transplant Surgery, Associate professor, 移植外科, 助手 (20324650)
KOZAKI Koichi Kyoto University, Transplant Surgery, COE, 医学研究科, 研究員 (10256274)
TANAKA Koichi Kyoto University, Transplant Surgery, Director, 移植外科, 教授 (20115877)
|
Project Period (FY) |
2005 – 2006
|
Project Status |
Completed (Fiscal Year 2006)
|
Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥2,600,000 (Direct Cost: ¥2,600,000)
|
Keywords | Liver transplantation / 13C phenylalanine / living donor / 栄養管理 |
Research Abstract |
Liver transplantation from a living donor has been acceptted procedure with excellent results. However, there remain a problem 'small-for-size graft' which sometimes resulted in poor patient and graft survival. Little is known regarding the impact of liver transplantation on amino acid requirements in children. Since plasma levels of the branched-chain amino acids (BCAA) are decreased in the presence of normal levels of the aromatic amino acids after liver transplantation, normalization of hepatic function may not fully correct changes in BCAA metabolism that occur in the pretransplant period. The goal of the present study was to determine total BCAA requirements of children following liver transplantation using 13C phenylalanine test. We investigated 13C phenylalanine test in living donor liver transplantation program.
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Report
(3 results)
Research Products
(80 results)
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[Journal Article] Cytotoxic T-cell-mediated defense against infections in human liver transplant recipients2007
Author(s)
Tanaka K, Uemoto S, Egawa H, Takada Y, Ozawa K, Teramukai S, Kasahara M, Ogawa K, Ono M, Sato H, Takai K, Fukushima M, Inaba K
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Journal Title
Liver Transpl 13
Pages: 287-287
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Cytotoxic T-cell-mediated defense against infections in human liver transplant recipients.2007
Author(s)
Tanaka K, Uemoto S, Egawa H, Takada Y, Ozawa K, Teramukai S, Kasahara M, Ogawa K, Ono M, Sato H, Takai K, Fukushima M, Inaba K
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Journal Title
Liver Transpl 13
Pages: 287-293
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cytotoxics T-cell-mediated defense against infections in human liver transplant recipients.2007
Author(s)
Tanaka K, Uemoto S, Egawa H, Takada Y, Ozawa K, Teramukai S, Kasahara M, Ogawa K, Ono M, Sato H, Takai K, Fukushima M, Inaba K.
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Journal Title
Liver Transpl 13
Pages: 287-293
Related Report
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[Journal Article] Long-term outcome of living donor liver transplantation for post Kasai biliary atresia (>15 years old)2006
Author(s)
Uchida Y, Kasahara M, Egawa H, Takada Y, Ogawa K, Ogura Y, Uryuhara K, Morioka D, Inomata Y, Kamiyama Y, Tanaka K
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Journal Title
Am J Transplantation 6
Pages: 2443-2443
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Classification of human liver transplant recipients by their preoperative CD8(+) T cell subpopulation and its relation to outcome2006
Author(s)
Tanaka K, Ozawa K, Teramukai S, Takada Y, Egawa H, Kaihara S, Fujimoto Y, Ogura Y, Kasahara M, Ono M, Sato H, Takai K, Fukushima M, Minato N
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Journal Title
Liver Transpl 12
Pages: 792-792
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Current role of liver transplantation for methylmalonic acidemia : A review of the literature2006
Author(s)
Kasahara M, Horikawa R, Tagawa M, Uemoto S, Yokoyama S, Shibata Y, Kawano T, Kuroda T, Honna T, Tanaka K, Saeki M
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Journal Title
Pediatr Transplant 10
Pages: 943-943
Description
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[Journal Article] Endoscopic treatment of biliary complications after right-lobe living-donor liver transplantation with duct-to-duct biliary anastomosis2006
Author(s)
Yazumi S, Yoshimoto T, Hisatsune H, Hasegawa K, Kida M, Tada S, Uenoyama Y, Yamauchi J, Shio S, Kasahara M, Ogawa K, Egawa H, Tanaka K, Chiba T
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Journal Title
J Hepatobiliary Pancreat Surg 13
Pages: 502-502
NAID
Description
「研究成果報告書概要(和文)」より
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[Journal Article] The Role of Plasmapheresis Therapy for Perioperative Management in ABO-Incompatible Adult Living Donor Liver Transplantation2006
Author(s)
Ashizawa T, Matsuno N, Yokoyama T, Kihara Y, Kuzuoka K, Taira S, Konno O, Jyojima Y, Akashi I, Nakamura Y, Hama K, Iwamoto H, Iwahori T, Nagao T, Kasahara M, Tanaka K
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Journal Title
Transplant Proc 38
Pages: 3629-3629
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Long-term outcome of living donor liver transplantation for post Kasai biliary atresia (>15 years old).2006
Author(s)
Uchida Y, Kasahara M, Egawa H, Takada Y, Ogawa K, Ogura Y, Uryuhara K, Morioka D, Inomata Y, Kamiyama Y, Tanaka K.
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Journal Title
Am J Transplantation 6
Pages: 2443-2448
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Classification of human liver transplant recipients by their preoperative CD8(+) T cell subpopulation and its relation to outcome2006
Author(s)
Tanaka K, Ozawa K, Teramukai S, Takada Y, Egawa H, Kaihara S, Fujimoto Y, Ogura Y, Kasahara M, Ono M, Sato H, Takai K, Fukushima M, Minato N.
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Journal Title
Liver Transpl. 12(5)
Pages: 792-800
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Current role of liver transplantation for methylmalonic acidemia : A review of the literature2006
Author(s)
Kasahara M, Horikawa R, Tagawa M, Uemoto S, Yokoyama S, Shibata Y, Kawano T, Kuroda T, Honna T, Tanaka K, Saeki M.
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Journal Title
Pediatr Transplant 10
Pages: 943-947
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Endoscopic treatment of biliary complications after right-lobe living-donor liver transplantation with duct-to-duct biliary anastomosis2006
Author(s)
Yazumi S, Yoshimoto T, Hisatsune H, Hasegawa K, Kida M, Tada S, Uenoyama Y, Yamauchi J, Shio S, Kasahara M, Ogawa K, Egawa H, Tanaka K, Chiba T.
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Journal Title
J Hepatobiliary Pancreat Surg. 13
Pages: 502-510
NAID
Description
「研究成果報告書概要(欧文)」より
Related Report
-
[Journal Article] The Role of Plasmapheresis Therapy for Perioperative Management in ABO-Incompatible Adult Living Donor Liver Transplantation2006
Author(s)
Ashizawa T, Matson N, Yokoyama T, Kihara Y, Kuzuoka K, Taira S, Konno O, Jyojima Y, Akashi I, Nakamura Y, Hama K, Iwamoto H, Iwahori T, Nagao T, Kasahara M, Tanaka K.
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Journal Title
Transplant Proc. 38
Pages: 3629-3632
Description
「研究成果報告書概要(欧文)」より
Related Report
-
[Journal Article] Endoscopic treatment of biliary complications after right-lobe living-donor liver transplantation with duct-to-duct biliary anastomosis.2006
Author(s)
Yazumi S, Yoshimoto T, Hisatsune H, Hasegawa K, Kida M, Tada S, Uenoyama Y, Yamauchi J, Shio S, Kasahara M, Ogawa K, Egawa H, Tanaka K, Chiba T.
-
Journal Title
J Hepatobiliary Pancreat Surg. 13
Pages: 502-510
NAID
Related Report
-
[Journal Article] Current role of liver transplantation for methylmalonic acidemia : A review of the literature2006
Author(s)
Kasahara M, Horikawa R, Tagawa M, Uemoto S, Yokoyama S, Shibata Y, Kawano T, Kuroda T, Honna T, Tanaka K, Saeki M
-
Journal Title
Pediatr Transpl 10
Pages: 943-947
Related Report
-
-
-
[Journal Article] Classification of human liver transplant recipients by their preoperative CD8(+) T cell subpopulation and its relation to outcome2006
Author(s)
Tanaka K, Ozawa K, Teramukai S, Takada Y, Egawa H, Kaihara S, Fujimoto Y, Ogura Y, Kasahara M, Ono M, Sato H, Takai K, Fukushima M, Minato N
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Journal Title
Liver Transpl 20
Pages: 792-800
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[Journal Article] Auxiliary Partial Orthotopic Living Donor Liver Transplantation : Kyoto University experience.2005
Author(s)
M.Kasahara, Y.Takada, H.Egawa, T.Kiuchi, Y.Inomata, K.Asonuma, S.Uemoto, K.Kozaki, Y.Fujimoto, H.Haga, M.Ueda, K.
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Journal Title
Am J Transplantation 5
Pages: 558-558
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[Journal Article] Living donor liver transplantation and noninvasive ventilation for exertional heat stroke and severe rhabdomyolysis.2005
Author(s)
Takahashi K, Chin K, Ogawa K, Kasahara M, Sakaguchi T, Hasegawa S, Sumi K, Nakamura T, Tamaki A, Mishima M, Nakamura T, Tanaka K
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Journal Title
Liver Transpl 11
Pages: 570-570
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[Journal Article] Living-donor liver transplantation for Hepatoblastoma2005
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Kasahara M, Ueda M, Haga H, Hiramatsu H, Kobayashi M, Adachi S, Sakamoto S, Oike F, Egawa H, Takada Y, Tanaka K
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Am J Transplantation 5
Pages: 2229-2229
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[Journal Article] New protocol of immunosuppression for liver transplantation across a ABO barrier : The use of Rituximab, hepatic arterial infusion, and preservation of spleen2005
Author(s)
Yoshizawa A, Sakamoto S, Ogawa K, Kasahara M, Uryuhara K, Oike F, Ueda M, Takada Y, Egawa H, Tanaka K
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Journal Title
Transplant Proc 37
Pages: 1718-1718
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[Journal Article] Living donor liver transplantation for pediatric patients with inheritable metabolic disorders2005
Author(s)
Morioka D, Kasahara M, Takada Y, Corrales JPG, Yoshizawa A, Sakamoto S, Taira K, Yoshitoshi EY, Egawa H, Shimada H, Tanaka K
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Am J Transplantation 5
Pages: 2754-2754
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[Journal Article] Auxiliary Partial Orthotopic Living Donor Liver Transplantation : Kyoto University experience.2005
Author(s)
M.Kasahara, Y.Takada, H.Egawa, T.Kiuchi, Y.Inomata, K.Asonuma, S.Uemoto, K.Kozaki, Y.Fujimoto, H.Haga, M.Ueda, K.Tanaka
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Journal Title
Am J Transplantation 5
Pages: 558-565
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Living donor liver transplantation and noninvasive ventilation for exertional heat stroke and severe rhabdomyolysis.2005
Author(s)
Takahashi K, Chin K, Ogawa K, Kasahara M, Sakaguchi T, Hasegawa S, Sumi K, Nakamura T, Tamaki A, Mishima M, Nakamura T, Tanaka K.
-
Journal Title
Liver Transpl. 11(5)
Pages: 570-572
Description
「研究成果報告書概要(欧文)」より
Related Report
-
-
-
-
-
-
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[Journal Article] New protocol of immunosuppression for liver transplantation across ABO barrier : The use of Rituximab, hepatic arterial infusion, and preservation of spleen2005
Author(s)
Yoshizawa A, Sakamoto S, Ogawa K, Kasahara M, Uryuhara K, Oike F, Ueda M, Takada Y, Egawa H, Tanaka K
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Journal Title
Transplant Proc. 37
Pages: 1718-1719
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「研究成果報告書概要(欧文)」より
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-
-
[Journal Article] Living donor liver transplantation for pediatric patients with inheritable metabolic disorders2005
Author(s)
Morioka D, Kasahara M, Takada Y, Corrales JPG, Yoshizawa A, Sakamoto S, Taira K, Yoshitoshi EY, Egawa H, Shimada H, Tanaka K.
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Journal Title
Am J Transplantation 5
Pages: 2754-2763
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[Book] こどもの肝移植2007
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