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Usefulness of the collage gel droplet embedded culture drug sensitivity test (CD-DST) in post-operative adjuvant chemotherapy

Research Project

Project/Area Number 17591333
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionOsaka University

Principal Investigator

KITAGAWA Toru  Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (40314322)

Co-Investigator(Kenkyū-buntansha) ITO Toshinori  Osaka University, Graduate School of Medicine, Endowed Chair Professor, 医学系研究科, 寄附講座教授 (20231152)
NISHIDA Toshiro  Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (40263264)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥2,300,000 (Direct Cost: ¥2,300,000)
Keywordschemo-sensitivity test / CD-DST / 5-FU / gastric cancer / colorectal cancer
Research Abstract

(I) Preclinical Study (in vitro)
Before the clinical study, the concentration and the co-culture time of anticancer drugs in the chemo-sensitivity test were investigated. CPT-11,Paclitaxel, Oxaliplatin and TS-1 were evaluated using murine tumor cell lines, human tumor cell lines and human cancer cells from gastric cancer patients or colorectal cancer patients.
(II) Clinical study
To investigate the usefulness of chemo-sensitivity test in post-operative adjuvant chemotherapy, the clinical study was started after the approval by the ethic committee of Osaka University School of Medicine.
All patients were randomized to the following 2 groups
Gastric cancer
Group A :
Chemo-sensitivity (+) □ Standard chemotherapy with 5-FU
Chemo-sensitivity (-) □ Second line chemotherapy with Paclitaxel
Group B :
Chemo-sensitivity (+)/(-) □ Standard chemotherapy with 5-FU
Colorectal cancer
Group A :
Chemo-sensitivity (+) □ Standard chemotherapy with 5-FU
Chemo-sensitivity (-) □ No chemotherapy
Group B :
Chemo-sensitivity (+)/(-) □ Standard chemotherapy with 5-FU
Primary end-point : Disease-free survival Secondary end-point : Overall survival
The preliminary clinical study, in which all patients were performed single protocol postoperative adjuvant chemotherapy using 5-FU, showed the longer disease-free survival and the longer overall survival in the chemo-sensitivity (+) group.
The chemo-sensitivity test is expected to predict the effectiveness of post-operative adjuvant chemotherapy.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (5 results)

All 2006 2005

All Journal Article (5 results)

  • [Journal Article] Common Diseaseインストラクションマニュアル : 膵癌2006

    • Author(s)
      伊藤壽記, 李千萬, 北川透
    • Journal Title

      Medicina 43・12

      Pages: 221-224

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] ゲフィチニブ耐性機構2006

    • Author(s)
      西田俊朗
    • Journal Title

      呼吸器外科 9・2

      Pages: 145-150

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Common Disease インストラクションマニュアル : 膵癌2006

    • Author(s)
      伊藤壽記, 李千萬, 北川透
    • Journal Title

      Medicina 43・12

      Pages: 221-224

    • Related Report
      2006 Annual Research Report
  • [Journal Article] エビデンスに基づいた癌化学療法 : Gastrointestinal stromal tumor(GIST)2005

    • Author(s)
      西田俊朗
    • Journal Title

      外科 67・4

      Pages: 412-418

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 消化器癌術後補助化学療法の個別化に向けて;抗癌剤感受性試験(CD-DST法)の可能性2005

    • Author(s)
      北川透, 伊藤壽記, 吉川正人, 他
    • Journal Title

      癌の臨床 51巻・1号

      Pages: 19-25

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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