| Project/Area Number |
17591343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kagawa prefectural College of Health Science |
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Principal Investigator |
KATO Ryoji kagawa Prefectural College of Health Science, medical technology, Professor, 保健医療学部, 教授 (00233833)
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| Co-Investigator(Kenkyū-buntansha) |
UENO Ichiro Kagawa prefectural College of Health Science, medical technology, Professor, 保健医療学部, 教授 (30382394)
AMAKAWA Masao Kagawa prefectural College of Health Science, medical technology, Assistant, 保健医療学部, 助手 (80331867)
KAMEKO Fumiko Shinshu University, School of health Science, Assistant, 医学部保健学科, 助手 (60126670)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | Thyroglobulin / Thyroid cancer / Lectin / Monoclonal antibody / Sugar chain / サイクログロブリン / 甲状腺濾胞がん / 診断法 |
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| Research Abstract |
Thymoglobulin (Tg) is produced by the thyroid with a molecular mass of 660,000 Dalton and a carbohydrate content of approximately 10%. Traditionally, the follow-up of differentiated thyroid carcinoma by measured serum Thymoglobulin. However, the concentration of thymoglobulin measured by immunoassay is greatly affected by presence of anti-Tg autoantiboies in sera.
We developed of new diagnostic method for clinical utility on thyroid carcinoma by chemical assay using LCA lectin(LCA reactive Tg method). The study was conducted on 103 serum samples form healthily volunteers, 159 patients with benign thyroid tumor, 170 patients with thyroid carcinoma.
The values of LCA reactive Tg method in patients with thyroid carcinoma was significantly lower than in patients those with benign thyroid tumor with serum Tg. The values of LCA reactive Tg method in serum may be useful for distinguishing between thyroid carcinoma and benign thyroid tumor.
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