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Basic and clinical study on chemoprevention for esophageal and/or head and neck cancer by green tee extract.

Research Project

Project/Area Number 17591380
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KAWANO Tatsuyuki  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (00186115)

Co-Investigator(Kenkyū-buntansha) NAGAI Kagami  東京医科歯科大学, 大学院・歯学総合研究科, 助教 (10251505)
NISHIKAGE Tetsuro  東京医科歯科大学, 医学部付属病院外科, 助教 (50321633)
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,130,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords癌の化学予防 / 緑茶カテキン / 食道癌 / 頭頸部癌 / 領域発癌 / 多発癌 / 多重癌 / 重複癌 / Field Cancerization / 頭頚部癌
Research Abstract

緑茶カテキン錠の服用コンプライアンスは良好であった.緑茶カテキン投与群では非投与群に比較して食道内異時多発癌の頻度は低い傾向を認めたが,ヨード不染粘膜の退縮・消失など,前癌病変や癌への直接的な影響を示唆する変化は見られず,同時期の非投与対照例との比較では,二次癌出現に関する有意差を認めなかった.また,投与開始直後での二次癌出現や,緑茶カテキン投与終了直後の二次癌出現なども見られており,さらに厳密な解析が必要と考えられる.さらに,食道内に多発ヨード不染粘膜を有す食道表在癌患者は,もともと高齢(60-80歳代)者が多く,ほとんどの例が多量の飲酒歴を有しているなど,他疾患に関わるリスクも高い.そのため,食道癌/頭頸部癌のみならず,他臓器での身体的イベントも多くみられ,同時期の対照例との比較で差が出にくかった可能性もある.対象症例数がなお少ないことも問題であり,緑茶カテキンによる食道癌,頭頸部癌の予防効果については,対照のとり方への工夫,対象症例数の増加をはかった後に,改めて検討し結論を出す必要がある.

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (15 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (13 results) Book (2 results)

  • [Journal Article] Endocytoscopic observation of esophageal squamous cell carcinoma2010

    • Author(s)
      Kumagai Y, Kawada K, Yamazaki S, Iida M, Ochiai T, MommaK, Odajima H, Kawachi H, Nemoto T, Kawano T, Takubo K.
    • Journal Title

      Digestive Endoscopy 22

      Pages: 10-16

    • NAID

      10028186341

    • Related Report
      2008 Final Research Report
  • [Journal Article] 中・下咽頭表在癌に対する内視鏡的粘膜切除術と内視鏡的粘膜下層剥離術2009

    • Author(s)
      川田研郎, 河野辰幸, 永井鑑, 西蔭徹郎, 中島康晃, 鈴木友宜, 星野明弘, 宮脇豊
    • Journal Title

      JOHNS 25

      Pages: 207-211

    • Related Report
      2008 Final Research Report
  • [Journal Article] Endocytoscopic observation for esophageal squamous cell carcinoma : Can biopsy histology omitted?2009

    • Author(s)
      Kumagai Y, Kawada K, Yamazaki S, Iida M, MommaK, Oda j ima H, Kawachi H, Nemoto T, Kawano T, Takubo K.
    • Journal Title

      Dis Esoph 22

      Pages: 505-512

    • Related Report
      2008 Final Research Report
  • [Journal Article] Reliability of endoscopic esophageal mucosectomy using TxHood, a multipurpose treatment hood2008

    • Author(s)
      Kawano T, Haruki S, Ogiya K, Kawada K, Nakajima Y, Nishikage T, Kojima K, Nagai K, Kawachi H.
    • Journal Title

      Surg Endosc 22

      Pages: 2466-2469

    • Related Report
      2008 Final Research Report
  • [Journal Article] Argon plasma coagulation for local recurrence of squamous cell carcinoma of the esophagus after endoscopic mucosal resection : technique and outcome2008

    • Author(s)
      Kawada K, Kawano T, Nagai K, Nishikage T, Nakajima Y, Ogiya K, Suzuki T, Haruki S, Kawachi H.
    • Journal Title

      Esophagus 5

      Pages: 27-32

    • Related Report
      2008 Final Research Report
  • [Journal Article] 食道m1・m2癌EMR後の長期成績2007

    • Author(s)
      川田研郎, 河野辰幸, 河内洋, 小林真季, 江石義信, 春木茂男, 荻谷一男, 中島康晃, 西蔭徹郎, 永井鑑
    • Journal Title

      胃と腸 42

      Pages: 1317-1322

    • Related Report
      2008 Final Research Report
  • [Journal Article] Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABPI, in esophageal squamous-cell carcinoma2007

    • Author(s)
      Tanaka K, Imoto I, Inoue J, Kozaki K, Tsuda H, Shimada Y, Aiko S, Yoshizumi Y, Iwai T, Kawano T, Inazawa J.
    • Journal Title

      Ongogene 26

      Pages: 6456-6468

    • Related Report
      2008 Final Research Report
  • [Journal Article] New argon plasma coagulation method for superfuical esophageal carcinomas : argon plasma coagulation - subepithelial ablation2007

    • Author(s)
      Kawada K, Kawano T, Momma K, Fujiwara J, Nagai K, Nishikage T, Nakajima Y, Ogiya K, Tanaka K, Haruki S, Iwai T.
    • Journal Title

      Digestive Endoscopy 19

      Pages: 147-152

    • Related Report
      2008 Final Research Report
  • [Journal Article] A tiny esophageal cancer diagnosed accutately by magnifying endoscopy and endocytoscopy : report of a case2007

    • Author(s)
      Kumagai Y, Takubo K, Iida M, Yamazaki S, Kawano T.
    • Journal Title

      Esophagus 4

      Pages: 173-176

    • Related Report
      2008 Final Research Report
  • [Journal Article] 表在性の早期癌における内視鏡診断と治療成績2006

    • Author(s)
      川田研郎, 永井鑑, 河野辰幸
    • Journal Title

      消化器内視鏡

      Pages: 1389-1395

    • Related Report
      2008 Final Research Report
  • [Journal Article] 微小癌に対する内視鏡治療の実際2006

    • Author(s)
      河野辰幸, 永井鑑, 小嶋一幸, 山田博之, 西蔭徹郎, 井ノロ幹人, 中島康晃, 関田吉久, 川田研郎, 荻谷一男, 田中浩司, 春木茂男
    • Journal Title

      消化器の臨床 9

      Pages: 549-553

    • Related Report
      2008 Final Research Report
  • [Journal Article] 口腔咽頭領域における内視鏡観察と腫瘍性病変の内視鏡治療2005

    • Author(s)
      永井鑑, 河野辰幸
    • Journal Title

      Gastroenterol Endosc 47

      Pages: 1012-1019

    • NAID

      10016422664

    • Related Report
      2008 Final Research Report
  • [Journal Article] 食道外科から見た下咽頭癌の治療戦略2005

    • Author(s)
      河野辰幸, 永井鑑, 西蔭徹郎, 中島康晃
    • Journal Title

      頭頚部癌 31

      Pages: 369-375

    • NAID

      10018271505

    • Related Report
      2008 Final Research Report
  • [Book] 拡大内視鏡 (NBIを含む) 食道. 食道・胃・十二指腸診断. 田尻久雄, 小山恒男編2009

    • Author(s)
      熊谷洋一, 川田研郎, 河野辰幸, 門馬久美子
    • Publisher
      羊土社
    • Related Report
      2008 Final Research Report
  • [Book] APC粘膜上皮下焼灼法 (APC-SEA) による食道表在癌の治療. EMRのコツと落とし穴. 工藤進英編2005

    • Author(s)
      川田研郎, 河野辰幸
    • Publisher
      中山書店
    • Related Report
      2008 Final Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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