| Project/Area Number |
17591384
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
GOI Takanori University of Fukui, Faculty of Medical Sciences, Assistant Professor, 医学部, 助手 (60225638)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Akio University of Fukui, Faculty of Medical Sciences, Professor, 医学部, 教授 (10174608)
|
|---|
| Project Period (FY) |
2005 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
|
| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
|
|---|
| Keywords | colorectal cancer / RIN1 gene / シグナル伝達系 |
|---|
| Research Abstract |
The RIN1 gene, located on chromosome 11q13.2, is a molecule consisting of a coding region of 2352 bp, has a domain on the 3'side that binds to H-Ras protein, and is presumed to be an important molecule in an intracellular signaling pathway. Since the RIN1 molecule belonging to the effector molecules of H-Ras has not been reported in colorectal or other digestive tract cancers to date, we investigated how the RIN1 gene was involved in colorectal cancer. Fifty-two (51.5%) of 101 colorectal cancer specimens strongly expressed the RIN1 gene compared to the adjacent normal colorectal tissue. The 5-year survival rate of patients positive for the expression of the RIN1 gene was significantly poorer at 55% than that (83%) of patients negative for the expression of the RIN1 gene. Also, We confirmed that RIN1 protein was localized chiefly in the cytoplasm of colorectal cancer cell line, and bound to 14-3-3 protein, but not to Ras protein.
These results indicate that the RIN1 gene serves as an important signal transduction system for evaluating the malignancy of colorectal cancer.
|
