| Project/Area Number |
17591385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
SUGAI Hidemitsu University of Yamanashi, University of Yamanashi Hospital, Research Associate, 医学部附属病院, 助手 (10345712)
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| Co-Investigator(Kenkyū-buntansha) |
KONO Koji University of Yamanashi, Department of Research Interdisciplinary graduate school of medicine and engineering, Associate Professor, 大学院医学工学総合研究部, 助教授 (40283204)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | Gastric Cancer / Monocyte / Cytokine / H2O2 |
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| Research Abstract |
It has been shown that tumor-infiltrated macrophage (Mφ) could induce T-cell apoptosis concomitant with down-regulation of signal transducing TCR zeta molecules in contact dependent manner as mechanisms of tumor-induced T cell dysfunction. In order to clarify the character of Mφ /monocytes in cancer patients, peripheral blood monocyte were analyzed for surface marker, production of H2O2, intracellular cytokine profile or redox status in patients with gastric cancer. As a result, increased production of H2O2 and IL-10 in monocytes was seen in gastric cancer patients in comparison to those in healthy donors, indicating that monocyte balance corresponded to oxidative state (M2 monocyte). Furthermore, the degree of oxidative state of monocytes was increased according to the disease progression. In conclusion, heterogeneity of monocytes exists in cancer-bearing hosts.
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