Research of the oxygen and glucose metabolism and their relationship in hepatic tumors with positron emission computed tomography
Project/Area Number |
17591430
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
TANIGUCHI Hiroki Kyoto Prefectural University of Medicine, Division of Digestive Surgery, Department of Surgery, Associate Professor (20217136)
|
Project Period (FY) |
2005 – 2007
|
Project Status |
Completed (Fiscal Year 2007)
|
Budget Amount *help |
¥3,630,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
Keywords | Tositron emission comnuted tomorranh / PET / henatic blood flow / oxveen metabolism / elucose metabolism / henatic tumor / tumor blood flow |
Research Abstract |
Malignant tumors repeat cell division and also proliferation actively even in bad environment. Consequently, it is thought that the glycolytic pathway largely contributes to getting energy for cell proliferation. In other words, anaerobic glucose metabolism is greatly facilitated not in normal tissue but in malignant tumor. Examination with positron emission computed tomography (PEI) using 18F-fluorodeoxygluoose (FDG) is to apply this phenomenon. Even though differential diagnosis which the tumor is benign or malignant and definition of invasive area are difficult, FDG-PET makes qualitative diagnosis possible by imaging study. On the other hand, FDG-PET enable quantitative evaluation of tumor glucose metabolism Detection rate by FDG-PET is extremely low in hepatocellular carcinoma (HCC), although it in malignant tumor is high even in metastatic liver tumor. It is thought that fundamental differences between (HCC) and the other cancer are due to their blood supply. HCC is rich in the bl
… More
ood vessels than the other cancer and it blood supply is abundant. In other words, it is thought that glucose metabolism is active in HCC. FDG-PET is indicator of anaerobic glucose metabolism and negative image of FDG-PET indicate to aerobic metabolism. Namely, it is expected that there is inverse correlation between blood flow in the cancer and anaerobic glucose metabolic rate (detection rate of FDG-PEI).The purpose of this research is to clarify the reason of low detection rate of HCC in FDG-PET. The relationship between the blood supply and anaerobic glucose metabolism of the tumor seem to be universal exceeding the kind of neoplasm. As results, anaerobic glucose metabolism related to blood flow and oxygen consumption in HCC, and also it related to oxygen consumption rate in other malignant tumors. It was thought that xygen deficiency is supplemented with elevation of effective oxygen consumption (oxygen consumption rate) in malignant tumors, but oxygen deficiency is supplemented with increase in blood flow in HCC. Less
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] 当院における虫垂炎手術例の検討2008
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柏本 錦吾, 藤信 明, 伊藤 剛, 中村 憲治, 渡辺 太治, 川口 耕, 谷口 弘毅, 内藤 和世
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[Journal Article] 膵腺胞細胞癌の1例2008
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中村 寛子, 藤信 明, 真崎 武, 伊藤 剛, 中村 憲治, 渡辺 太治, 柏本 錦吾, 川口 耕, 谷口 弘毅, 内藤 和世
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京都府立与謝の海病院誌 5
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上田 英史, 藤信 明, 筏 さやか, 平山 きふ, 野本 剛史, 川口 耕, 柏本 錦吾, 中村 憲治, 渡辺 太治, 伊藤 剛, 谷口 弘毅, 内藤 和世
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京都府立与謝の海病院誌 5
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[Journal Article] 乳腺腺様嚢胞癌の1例2008
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青木 史子, 中村 憲治, 伊藤 剛, 真崎 武, 柏本 錦吾, 川口 耕, 渡辺 太治, 藤信 明, 谷口 弘毅, 内藤 和世
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京都府立与謝の海病院誌 5
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[Journal Article] 大腸腺扁平上皮癌の1例2008
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岡田 悟, 伊藤 剛, 真崎 武, 柏本 錦吾, 藤信 明, 渡辺 太治, 中村 憲治, 川口 耕, 谷口 弘毅, 内藤 和世
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[Journal Article] A Saved Case of Nonocclusive Mesenteric Ischemia with Portal Venous Gas by Simultaneous Operation2008
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Japanese Journal of Gastroenterological Surgery 41-1
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Tsuyoshi, Itoh, Nobuaki, Fuji, Hiroki, Taniguchi, Taiji, Watanabe, Toshiyuki, Kosuga, Kingo, Kashimoto, Kazuyo, Naito
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Hiroshi, Ohtaki, Nobuaki, Fuji, Takanori, Nagaoka, Yasuhito, Hayashi, Tsutomu, Yamaguchi, Takeshi, Nomoto, Masako, Ikuta, Kazuhiko, Tokita, Hiroki, Taniguchi
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[Journal Article] A case report of acinar cell carcinoma in the panceras2008
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Hiroko, Nakamura, Nobuaki, Fuji, Takeshi, Mazaki, Tsuyoshi, Itoh, Kenji, Nakamura, Taiji, Watanabe, Kingo, Kashimoto, Tsutomu, Kawaguchi, Hiroki, Taniguchi, Kazuyo, Naito
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Journal of Kyoto Prefectural Yosanoumi Hospital 5-1
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[Journal Article] A case of focal nodular hyperplasia that was difficult to be differentiated from hepatocellular carcinoma2008
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Tsutomu, Kawaguchi, Nobuaki, Fuji, Tsuyoshi, Itoh, Kenji, Nakamura, Taiji, Watanabe, Kingo, Kashimoto, Hiroki, Taniguchi, Kazuyo, Naito
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Journal of Kyoto Prefectural Yosanoumi Hospital 5-1
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[Journal Article] A case found gastric cancer, colorectal cancer, and prostatic cancer taking popular erythroderma opportunity2008
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[Journal Article] A case of adenoid cystic carcinoma of the breast2008
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[Journal Article] A case of adenosquamous carcinoma of the colon2008
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Journal of Kyoto Prefectural Yosanoumi Hospital 5-1
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[Journal Article] A resected case of cystic tumor of the pancreas2008
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[Journal Article] 膵腺胞細胞癌の1例2008
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中村寛子, 藤信明, 真崎武, 伊藤剛, 中村憲治, 渡辺太治, 柏本錦吾, 川口耕, 谷口弘毅, 内藤和世
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上田英史, 藤信明, 筏さやか, 平山きふ, 野本剛史, 川口耕, 柏本錦吾, 中村憲治, 渡辺太治, 伊藤剛, 谷口弘毅, 内藤和世
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[Journal Article] 乳腺腺様嚢胞癌の1例2008
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[Presentation] 乳腺腺様嚢胞癌の1例2007
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青木 史子, 伊藤 剛, 真崎 武, 藤信 明, 中村 憲司, 渡辺 太治, 柏本 錦吾, 谷口 弘毅, 内藤 和世
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第182回近畿外科学会
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Year and Date
2007-12-08
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第182回近畿外科学会
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2007-12-08
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第182回近畿外科学会
Place of Presentation
大阪
Year and Date
2007-12-08
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[Presentation] 大腸腺扁平上皮癌の1例2007
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第182回近畿外科学会
Place of Presentation
大阪
Year and Date
2007-12-08
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[Presentation] A case report of acinar cell carcinoma in the panceras2007
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Hiroko, Nakamura, Nobuaki, Fuji, Takeshi, Mazaki, Tsuyoshi, Itoh, Kenji, Nakamura, Taiji, Watanabe, Kingo, Kashimoto, Tsutomu, Kawaguchi, Hiroki, Taniguchi, Kazuyo, Naito
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The 182nd annual meeting of Kinki Surgical Society
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Osaka
Year and Date
2007-12-08
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[Presentation] A case of focal nodular hyperplasia that was difficult to be differentiated from hepatocellular carcinoma2007
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The 182nd annual meeting of Kinki Surgical Society
Place of Presentation
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Year and Date
2007-12-08
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[Presentation] A case found gastric cancer, colorectal cancer, and prostatic cancer taking popular erythroderma opportunity2007
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The 182nd annual meeting of Kinki Surgical Society
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Year and Date
2007-12-08
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[Presentation] A case of adenoid cystic carcinoma of the breast2007
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The 182nd annual meeting of Kinki Surgical Society
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[Presentation] A case of adenosquamous carcinoma of the colon2007
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The 182nd annual meeting of Kinki Surgical Society
Place of Presentation
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Year and Date
2007-12-08
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[Presentation] A resected case of cystic tumor of the pancreas2007
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Katsutoshi, Shoda, Tsuyoshi, Itoh, Takeshi, Mazaki, Nobuaki, Fuji, Kenji, Nakamura, Taiji, Watanabe, Kingo, Kashimoto, Tsutomu, Kawaguchi, Hiroki, Taniguchi, Kazuyo, Naito
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The 182nd annual meeting of Kinki Surgical Society
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Year and Date
2007-12-08
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[Presentation] Investigation of 293 cases with acute appendicitis from 2001 to 20062007
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The 182nd annual meeting of Kinki Surgical Society
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[Presentation] 地方病院の臨時手術の実際2007
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[Presentation] Investigation for the effect of drugs affecting the blood flow in hepatic tumor2007
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[Presentation] A Saved Case of Nonocclusive Mesenteric Ischemia with Portal Venous Gas by Simultaneous Operation2007
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The 62th annual meeting of Japanese Society of Gastroenterological Surgery
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[Presentation] Examination of factors contributing to long term survival after surgery for liver metastasis from colorectal cancer2007
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[Presentation] Investigation of the oxygen and glucose metabolism and their relationship in hepatic tumors with positron emission computed tomography2007
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