| Project/Area Number |
17591430
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
TANIGUCHI Hiroki Kyoto Prefectural University of Medicine, Division of Digestive Surgery, Department of Surgery, Associate Professor (20217136)
|
|---|
| Project Period (FY) |
2005 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,630,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | Tositron emission comnuted tomorranh / PET / henatic blood flow / oxveen metabolism / elucose metabolism / henatic tumor / tumor blood flow |
|---|
| Research Abstract |
Malignant tumors repeat cell division and also proliferation actively even in bad environment. Consequently, it is thought that the glycolytic pathway largely contributes to getting energy for cell proliferation. In other words, anaerobic glucose metabolism is greatly facilitated not in normal tissue but in malignant tumor. Examination with positron emission computed tomography (PEI) using 18F-fluorodeoxygluoose (FDG) is to apply this phenomenon. Even though differential diagnosis which the tumor is benign or malignant and definition of invasive area are difficult, FDG-PET makes qualitative diagnosis possible by imaging study. On the other hand, FDG-PET enable quantitative evaluation of tumor glucose metabolism Detection rate by FDG-PET is extremely low in hepatocellular carcinoma (HCC), although it in malignant tumor is high even in metastatic liver tumor. It is thought that fundamental differences between (HCC) and the other cancer are due to their blood supply. HCC is rich in the bl
… More
ood vessels than the other cancer and it blood supply is abundant. In other words, it is thought that glucose metabolism is active in HCC. FDG-PET is indicator of anaerobic glucose metabolism and negative image of FDG-PET indicate to aerobic metabolism. Namely, it is expected that there is inverse correlation between blood flow in the cancer and anaerobic glucose metabolic rate (detection rate of FDG-PEI).The purpose of this research is to clarify the reason of low detection rate of HCC in FDG-PET.
The relationship between the blood supply and anaerobic glucose metabolism of the tumor seem to be universal exceeding the kind of neoplasm. As results, anaerobic glucose metabolism related to blood flow and oxygen consumption in HCC, and also it related to oxygen consumption rate in other malignant tumors. It was thought that xygen deficiency is supplemented with elevation of effective oxygen consumption (oxygen consumption rate) in malignant tumors, but oxygen deficiency is supplemented with increase in blood flow in HCC. Less
|
