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Constitution of a system of microarray CGH analysis for wide-screening and a research for genes responsible for hepatocellular carcinoma

Research Project

Project/Area Number 17591431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionOsaka City University

Principal Investigator

KUBO Shoji  Osaka City University, Graduate School of Medicine Department of Hepato-Biliary-Pancreatic Surgery, Associated Professor (80221224)

Co-Investigator(Kenkyū-buntansha) NISHIGUCHI Shuhei  Hyogo Medical College, Department of Hepatology, Professor (10192246)
TANAKA Hiromu  Osaka City University, Graduate School of Medicine Department of Hepato-Biliary-Pancreatic Surgery, Lecturer (90275256)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,280,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsHepatocellular carcinoma / Hepatitis B virus gene / Hepatitis C virus / Cholangiocarcinoma / Hepatic progenitor cell / Methylation of DNA / high mobility group A2 / Interferon
Research Abstract

HBV DNA was integrated at random sites of human DNA, and the MLL2 gene was cone of the targets for integration. Our results suggest that HBV DNA might modulate human genes near integration sites, followed by integration site - specific expression of such genes during hepatocarcinogenesis.
The expression and alternation of high mobility group A2 (HMGA2) were investigated by RT-PCR using cancerous tissues and noncancerous tissues in patients with hepatocellular carcinoma. The expression was found in one-third of cancerous tissues and the prevalence increased in less differentiated carcinoma. The alternation also increased in poorly differentiated hepatocellular carcinoma. The results indicate the expression and alternation of HMGA2 correlated with the development of hepatocellular carcinoma.
Although high concentration of serum cytokeratin-19 fragment (CYFRA 21-1) were often detected in patients with a tumor diameter greater than 5 cm of tumor thrombus in the major portal vein, CYFRA 21\1 is not a useful diagnostic tool for hepatocellular carcinoma because of its low sensitivity.
In patients who underwent liver resection for hepatocellular carcinoma, the results were superior in patients who respond interferon therapy than in patients who did not respond the therapy or who lacks the therapy. Interferon therapy can improve postoperative outcomes because of suppression of recurrence and preventing prognosis of cirrhosis, especially when interferon therapy has controlled their active hepatitis.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (113 results)

All 2008 2007 2006 2005 Other

All Journal Article (65 results) (of which Peer Reviewed: 26 results) Presentation (42 results) Book (6 results)

  • [Journal Article] Second hepatic resection for recurennt hepatocellular carcinoma in patients with chronic hepatitis C2008

    • Author(s)
      Kubo S, et. al.
    • Journal Title

      World Journal of Surgery 32

      Pages: 632-638

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Second hepatic resection for recurennt hepatocellular carcinoma in patients with chronic hepatitis C2008

    • Author(s)
      Kubo, S, et. al.
    • Journal Title

      World Journal of Surgery 32

      Pages: 632-638

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Serum cytokeratin 19 fragment(CYFRA21-1) as a prognostic factor in intrahepatic cholangiocarcinoma2008

    • Author(s)
      Uenishi T, Kubo S, et. al.
    • Journal Title

      Annals of Surgical Oncology 15

      Pages: 583-587

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Second hepatic resection for recurennt hepatocellular carcinoma in patients with chronic hepatitis C2008

    • Author(s)
      Kubo S, et. al.
    • Journal Title

      World Joumal of Surgery 32

      Pages: 632-638

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of lamivudine on outocome after liver resection for hepatocellular carcinoma in patients with active replication of hepatitis B virus2007

    • Author(s)
      Kubo S, et. al.
    • Journal Title

      Hepatology Research 37

      Pages: 94-100

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] A histopathological study on combined hepatocellular and cholangiocarcinoma:cholangiocarcinoma component is originated from hepatocellular carcinoma.2007

    • Author(s)
      Wakasa T, Kubo S, et. al.
    • Journal Title

      Hepatogastroenterology 54

      Pages: 508-513

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Surgical treatment for hepatocellular carcinoma detected after success ful interferon therapy2007

    • Author(s)
      Kubo S, et. al.
    • Journal Title

      Surgery Today 37

      Pages: 285-290

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Potential role of vitamin K2 as a chemopreventive agent against hepatocellular carcinoma2007

    • Author(s)
      Tamori A, Kubo S, et. al.
    • Journal Title

      Hepatology Research 37

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of lamivudine on outocome after liver resection for hepatocellular carcinoma in patients with active replication of hepatitis B virus2007

    • Author(s)
      Kubo, S, et. al.
    • Journal Title

      Hepatology Research 37

      Pages: 94-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] A histopathological study on combined hepatocellular and cholangiocarcinoma: cholangiocarcinoma component is originated from hepatocellular carcinoma2007

    • Author(s)
      Wakasa, T, Kubo, S, et. al.
    • Journal Title

      Hepatogastroenterology 54

      Pages: 508-513

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Surgical treatment for hepatocellular carcinoma detected after successful interferon therapy2007

    • Author(s)
      Kubo, S, et. al.
    • Journal Title

      Surgery Today 37

      Pages: 285-290

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Potential role of vitamin K2 as a chemopreventive agent against hepatocellular carcinoma2007

    • Author(s)
      Tamori, S, Kubo, S, et. al.
    • Journal Title

      Hepatology Research 37

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Surgical treatment for hepatocellular carcinoma detected after successful interferon therapy2007

    • Author(s)
      Kubo S, et. al.
    • Journal Title

      Surg Today 37

      Pages: 285-290

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for massive blood loss during liver resection for hepatocellular carcinoma in patients with cirrhosis2007

    • Author(s)
      Kubo S, et. al.
    • Journal Title

      Hepatogastroenterology 54

      Pages: 830-833

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 解細胞癌に併存する結節性病変のうち治療の対象となる病変は2007

    • Author(s)
      久保 正二, 他
    • Journal Title

      消化器外科 30

      Pages: 589-600

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 大血管内進展を伴う進行再発肝細胞癌に対する外科治療2007

    • Author(s)
      久保 正二, 他
    • Journal Title

      消化器外科 31

      Pages: 157-164

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Clinicopathological implications of immunohistochemically demonstrated mucin core protein expression in hepatocellular carcinoma.2006

    • Author(s)
      Ichikawa T, Kubo S, et. al.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Surgery 13(3)

      Pages: 245-251

    • NAID

      10019167392

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clinical significance of serum cytokeratin-19 fragment (CYFRA21-1) in hepatocellular carcinoma.2006

    • Author(s)
      Uenishi T, Kubo S, et. al.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Surgery 13(3)

      Pages: 239-244

    • NAID

      10019167353

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Influence of interferon therapy on outcome after surgery for hepatitis C virus-related hepatocellular carcinoma2006

    • Author(s)
      Uenishi T, Kubo S, et. al.
    • Journal Title

      Hepatology Research 36(3)

      Pages: 195-200

    • NAID

      10018640174

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hepatocellular carcinoma arising from nonalcoholic steatohepatitis:report of two cases.2006

    • Author(s)
      Hai S, Kubo S, et. al.
    • Journal Title

      Surgery Today 36(4)

      Pages: 390-394

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clinicopathological implications of immunohistochemically demonstrate d mucin core protein expression in hepatocellular carcinoma2006

    • Author(s)
      Ichikawa, T., Kubo, S., et. al.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Su rgery 13

      Pages: 245-251

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clinical significance of serum cytokeratin-19 fragment (CYFRA 21-1) in hepatocellular carcinoma2006

    • Author(s)
      Uenishi, Kubo, S, et. al.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Surgery 13

      Pages: 239-244

    • NAID

      10019167353

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Influence of interferon therapy on outcome after surgery for hepatitis C virus-related hepatocellular carcinoma2006

    • Author(s)
      Uenishi, T, Kubo S, et. al.
    • Journal Title

      Hepatology Research 36

      Pages: 195-200

    • NAID

      10018640174

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hepatocellular carcinoma arising from nonalcoholic steatohepatitis: report of two cases2006

    • Author(s)
      Hai, S, Kubo, S, et. al.
    • Journal Title

      Surgery Today 36

      Pages: 390-394

    • NAID

      10017320082

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clinicopathological implication of immunohistochemically demonstrated mucin core protein expression in hepatocellular carcinoma.2006

    • Author(s)
      Ichikawa T, Kubo S, et al.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Surgery 13(3)

    • NAID

      10019167392

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Clinical significance of serum cytokeratin-19 fragment (CYFRA 21-1) in hepatocellular carcinoma.2006

    • Author(s)
      Uenishi T, Kubo S, et al.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Surgery 13(3)

    • NAID

      10019167353

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Influence of interferon therapy on outcome after surgery for hepatitis C virus-related hepatocellular carcinoma2006

    • Author(s)
      Uenishi T, Kubo S, et al.
    • Journal Title

      Hepatology Research 36(3)

      Pages: 195-200

    • NAID

      10018640174

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Hepatocellular carcinoma arising from nonalcoholic aseatohepatitis : report of two cases.2006

    • Author(s)
      Hai, S, Kubo S, et al.
    • Journal Title

      Surgery Today 36(4)

      Pages: 390-394

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 生命予後・死因から見たC型肝炎関連肝細胞癌切除例におけるインターフェロン治療の意義2006

    • Author(s)
      上西崇弘, 久保正二, 他
    • Journal Title

      消化器科 42(3)

      Pages: 311-316

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 特集 肝細胞がん患者にどう対応するか4.外科治療の進め方2)術前・術後の補助療法はどこまで効果が期待できるか2006

    • Author(s)
      久保正二, 田中 宏, 他
    • Journal Title

      臨床腫瘍プラクティス 2(4)

      Pages: 362-366

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 【肝癌の診療 最新の進歩】 肝癌の発癌予防 C型肝炎における肝発癌予防 C型肝炎根治療法後びインターフェロン療法による肝癌再発予防2006

    • Author(s)
      西口修平, 久保正二, 他
    • Journal Title

      臨床消化器内科 21(7)

      Pages: 1070-1075

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Type IV collagen 7s domain as a predictor of poor efficacy of portal vein embolization before major hepatectomy.2005

    • Author(s)
      Wu JS, Kubo S, et. al.
    • Journal Title

      Surgery Today 35

      Pages: 41-46

    • NAID

      10014260007

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of long-term postoperative interferon therapy on intrahepatic recurrence and survival rate after resection of hepatitis C virus-related hepatocellular carcinoma.2005

    • Author(s)
      Nishiguchi S, Kubo S, et. al.
    • Journal Title

      Intervirology 48

      Pages: 71-75

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Recurrence rate and transplantability after liver resection in patients with hepatocellular carcinoma who initially met transplantation criteria.2005

    • Author(s)
      Tanaka H, KuboS, et. al.
    • Journal Title

      Transplantation Proceedings 37

      Pages: 1254-1256

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Alcohol abuse as an etiologic factor for hepatocellular carcinoma in Japan.2005

    • Author(s)
      Kubo S, et. al.
    • Journal Title

      Hepatology Research 31

      Pages: 73-78

    • NAID

      10016478327

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Clinicopathologic features and outcome after liver resection for hepatocellular carcinoma in patients with concurrent versus previous chronic hepatitis B.2005

    • Author(s)
      Kubo S, et. al.
    • Journal Title

      Surgery Today 35

      Pages: 216-222

    • NAID

      10015424027

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Potentiality of combined hepatocellular and intrahepatic cholangiocellular carcinoma originating from a hepatic precursor cell:Immunohistochemical evidence.2005

    • Author(s)
      Tanaka S, Kubo S, et. al.
    • Journal Title

      Hepatology Research 32

      Pages: 52-57

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Hepatitis B virus DNA integration in hepatocellular carcinoma after interferon-induced disappearance of hepatitis C virus.2005

    • Author(s)
      Tamori A, Kubo S, et. al.
    • Journal Title

      American Journal of Gastroenterology 100

      Pages: 1748-1753

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Alteration of gene expression in human hepatocellular carcinoma with integrated hepatitis B virus DNA.2005

    • Author(s)
      Tamori A, Kubo S, et. al.
    • Journal Title

      Clinical Cancer Research 11

      Pages: 5821-5826

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Prognostic effects of causative virus in hepatocellular carcinoma according to the Japan integrated staging (JIS) score.2005

    • Author(s)
      Kubo S, et. al.
    • Journal Title

      Journal of Gastroenterology 40

      Pages: 972-979

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Immunohistologic attempt to find carcinogenesis from hepatic progenitor cell in hepatocellular carcinoma.2005

    • Author(s)
      Yamamoto T, Kubo S, et. al.
    • Journal Title

      Digestive Surgery 22

      Pages: 364-370

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Type IV collagen 7s domain as a predictor of poor efficacy of portal vein embolization before major hepatectomy2005

    • Author(s)
      Wu, Js, Kubo, s, et. al.
    • Journal Title

      Surgery Today 35

      Pages: 41-46

    • NAID

      10014260007

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of long-term postoperative interferon therapy on intrahepatic recurrence and survival rate after resection of hepatitis C virus-related hepatocellular carcinoma2005

    • Author(s)
      Nishiguchi, S, Kubo, S, et. al.
    • Journal Title

      Intervirology 48

      Pages: 71-75

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Recurrence rate and transplantability after liver resection in patients with hepatocellular carcinoma who initially met transplantation criteria Transplantation Proceedings2005

    • Author(s)
      Tanaka, H, Kubo, S, et. al.
    • Journal Title

      37

      Pages: 1254-1256

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Alcohol abuse as an etiologic factor for hepatocellular carcinoma in Japan.2005

    • Author(s)
      Kubo, S, et. al.
    • Journal Title

      Hepatology Research 31

      Pages: 73-78

    • NAID

      10016478327

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Clinicopathologic features and outcome after liver resection for hepatocellular carcinoma in patients with concurrent versus previous chronic hepatitis B2005

    • Author(s)
      Kubo, S, et. al.
    • Journal Title

      Surgery Today 35

      Pages: 216-222

    • NAID

      10015424027

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Potentiality of combined hepatocellular and intrahepatic cholangiocellular carcinoma originating from a hepatic precursor cell: Immunohistochemical evidence2005

    • Author(s)
      Tanaka, S, et. al.
    • Journal Title

      Hepatology Research 32

      Pages: 52-57

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Hepatitis B virus DNA integration in hepatocellular carcinoma after interferon-induced disappearance of hepatitis C virus2005

    • Author(s)
      Tamori, A., Kubo, S., et. al.
    • Journal Title

      American Journal of Gastroenterology 100

      Pages: 1748-1753

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Alteration of gene expression in human hepatocellular carcinoma with integrated hepatitis B virus DNA2005

    • Author(s)
      Tamori, A Kubo S, et. al.
    • Journal Title

      Clinical Cancer Research 11

      Pages: 5821-5826

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Prognostic effects of causative virus in hepatocellular carcinoma according to the Japan integrated staging (JIS) score2005

    • Author(s)
      Kubo, S, et. al.
    • Journal Title

      Journal of Gastroenterology 40

      Pages: 972-979

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Immunohistologic attempt to find carcinogenesis from hepatic progenitor cell in hepatocellular carcinoma2005

    • Author(s)
      Yamamoto, T, et. al.
    • Journal Title

      Digestive Surgery 22

      Pages: 364-370

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Effect of long-term postoperative interferon therapy on intrahepatic recurrence and survival rate after resection of hepatitis C virus-related hepatocellular carcinoma2005

    • Author(s)
      Nishiguchi S, Kubo S, et al.
    • Journal Title

      Intervirology 48(1)

      Pages: 71-75

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Alcohol abuse as an etiologic factor for hepatocellular carcinoma in Japan2005

    • Author(s)
      Kubo S, et al.
    • Journal Title

      Hepatology Research 35(2)

      Pages: 75-80

    • NAID

      10016478327

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Clinicopathologic features and outcome after liver resection for hepatocellular carcinoma in patients with concurrent versus previous chronic hepatitis B2005

    • Author(s)
      Kubo S, et al.
    • Journal Title

      Surgery Today 35(3)

      Pages: 216-222

    • NAID

      10015424027

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Potentiality of combined hepatocellular carcinoma and intrahepatic cholangiocellular carcinoma originating from a hepatic precursor cell : immunohistochemical evidence2005

    • Author(s)
      Tanaka S, Kubo S, et al.
    • Journal Title

      Hepatology Research 32(1)

      Pages: 52-57

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hepatitis B virus DNA integration in hepatocellular carcinoma after interferon-induced disappearance of hepatitis C virus2005

    • Author(s)
      Tamori A, Kubo S, et al.
    • Journal Title

      American Journal of Gastroenterology 100(8)

      Pages: 1748-1753

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Alternation o gene expression in human hepatocellular carcinoma with integrated hepatitis B virus DNA2005

    • Author(s)
      Tamori A, Kubo S, et al.
    • Journal Title

      Clinical Cancer Research 11(16)

      Pages: 5821-5826

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Prognostic effects of causative virus in hepatocellular carcinoma according to the Japan Integrated Staging (JIS) system2005

    • Author(s)
      Kubo S, et al.
    • Journal Title

      Journal of Gastroenterology 40(10)

      Pages: 972-979

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Immunohistologic attempt to find carcinogenesis from hepatic progenitor cell in hepatocellular carcinoma2005

    • Author(s)
      Kubo S, et al.
    • Journal Title

      Digestive Surgery 22(5)

      Pages: 364-370

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Serum cytokeratin 19 fragment (CYFRA21-1) as a prognostic factor in intrahepatic cholangiocarcinoma.

    • Author(s)
      Uenishi T, Kubo S, et. al.
    • Journal Title

      Annals of Surgical Oncology (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Response to interferon therapy affects tisk factors for postoperative reucrrence of hepatitis C virus-related hepatocellular carcinoma

    • Author(s)
      Uenishi T, Kubo S, et. al.
    • Journal Title

      Journal of Surgical Oncology (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Differences in molecular alterations of hepatocellular carcinoma between patients with a sustained virological response and those with HCV infection

    • Author(s)
      Hayashi T, Kubo S, et. al.
    • Journal Title

      Liver International (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Serum cytokeratin 19 fragment (CYFRA21-1) as a prognostic factor in intrahepatic cholangiocarcinoma

    • Author(s)
      Uenishi, T, Kubo S, et. al.
    • Journal Title

      Annals of Surgical Oncology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Response to interferon therapy affects tisk factors for postoperative reucrrence of hepatitis C virus-related hepatocellular carcinoma

    • Author(s)
      Uenishi, T, Libp, S, et. al.
    • Journal Title

      Journal of Surgical Oncology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Differences in molecular alterations of hepatocellular carcinoma between patients with a sustained virological response and those with HCV infection

    • Author(s)
      Hayashim, T, Kubo, S, et. al.
    • Journal Title

      Liver International (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 予後因子からみたC型肝炎関連肝細胞癌切除後再発に対する再肝切除の適応2007

    • Author(s)
      久保 正二, 他
    • Organizer
      第11回 日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 予後因子からみたC型肝炎関連肝細胞癌切除後再発に対する再肝切除の適応2007

    • Author(s)
      久保 正二、他
    • Organizer
      第11回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2007-10-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular alterations in hepatocellular carcionoma from patients in which hepatitis C virus was eradicated by interferon2007

    • Author(s)
      Tamori A, Kubo S, et. al.
    • Organizer
      66th Annual Meeting ofthe Japanese Cancer Assciation
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Molecular alterations in hepatocellular carcionoma from patients in which hepatitis C virus was eradicated by interferon2007

    • Author(s)
      Tamori A, Kubo S, et, al.
    • Organizer
      66th Annual meeting of the japallese cancer assciation
    • Place of Presentation
      Yokohama
    • Year and Date
      2007-10-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] C型肝炎関連肝細胞癌切除成績向上におけるインターフェロン治療の意義2007

    • Author(s)
      上西 崇弘、久保 正二, 他
    • Organizer
      第62回 日本消化器外科学会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C型肝炎関連肝細胞癌多中心性再発に対するインターフェロン治療を含めた治療戦略2007

    • Author(s)
      市川 剛、久保 正二, 他
    • Organizer
      第62回 日本消化器外科学会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-18
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C型肝炎関連肝細胞癌切除成績向上におけるインターフェロン治療の意義2007

    • Author(s)
      上西 崇弘、久保 正二、他
    • Organizer
      第62回日本消化器外科学会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] C型肝炎関連肝細胞癌多中心性再発に対するインターフェロン治療を含めた治療戦略2007

    • Author(s)
      市川 剛、久保 正二、他
    • Organizer
      第62回日本消化器外科学会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 背景肝疾患による肝細胞癌遺伝子メチル化パターンの相違2007

    • Author(s)
      林 健博、久保 正二, 他
    • Organizer
      第43回 日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C型肝炎関連肝細胞癌に対するインターフェロン治療効果と術式選択2007

    • Author(s)
      上西 崇弘、久保 正二, 他
    • Organizer
      第43回 日本肝臓学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-06-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 背景肝疾患による肝細胞癌遺伝子メチル化パターンの相違2007

    • Author(s)
      林 健博、久保 正二、他
    • Organizer
      日本肝臓学会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] C型肝炎関連肝細胞癌に対するインターフェロン治療効果と術式選択2007

    • Author(s)
      上西 崇弘、久保 正二、他
    • Organizer
      日本肝臓学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-06-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] C型肝炎に対するインターフェロン有効例における肝細胞癌切除後成績の検討2007

    • Author(s)
      大場 一輝、久保 正二, 他
    • Organizer
      第43回 日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C型肝炎に対するインターフェロン有効例における肝細胞癌切除後成績の検討2007

    • Author(s)
      大揚 一輝、久保 正二、他
    • Organizer
      日本肝臓学会
    • Place of Presentation
      東京
    • Year and Date
      2007-05-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] 様々な肝切除におけるテープガイド法の応用2007

    • Author(s)
      田中 宏、久保 正二, 他
    • Organizer
      第107回 日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 非B非C肝細胞癌切除例の臨床病理学的検討2007

    • Author(s)
      新川 寛二、久保 正二, 他
    • Organizer
      第107回 日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C型肝炎関連肝細胞癌切除再発に対する再肝切除の適応2007

    • Author(s)
      久保 正二, 他
    • Organizer
      第107回 日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 様々な肝切除におけるテープガイド法の応用2007

    • Author(s)
      田中 宏、久保 正二、他
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 非B非C肝細胞癌切除例の臨床病理学的検討2007

    • Author(s)
      新川 寛二、久保 正二、他
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] C型肝炎関連肝細胞癌切除再発に対する再肝切除の適応2007

    • Author(s)
      久保 正二、他
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 切除成績からみたC型肝炎関連肝細胞癌におけるインターフェロン(IFN)治療の意義2007

    • Author(s)
      上西 崇弘、久保 正二, 他
    • Organizer
      第107回 日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 切除成績からみたC型肝炎関連肝細胞癌におけるインターフェロン(IFN)治療の意義2007

    • Author(s)
      上西 崇弘、久保 正二、他
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-04-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 肝切除後成績からみたミラノ基準内間細胞癌に対する移植適応2006

    • Author(s)
      田中 宏、久保 正二, 他
    • Organizer
      第68回 日本臨床外科学会総会
    • Place of Presentation
      広島
    • Year and Date
      2006-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 再発肝細胞癌に対する肝切除後予後規定因子と治療成績向上策2006

    • Author(s)
      久保 正二, 他
    • Organizer
      第68回 日本臨床外科学会総会
    • Place of Presentation
      広島
    • Year and Date
      2006-11-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] インターフェロン完治例肝癌とHCV肝癌における遺伝子変化2006

    • Author(s)
      林 健博、久保 正二, 他
    • Organizer
      第10回 日本肝臓学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2006-10-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] インターフェロン治療の肝炎制御効果別にみた C型肝炎関連肝細胞癌の外科治療戦略2006

    • Author(s)
      上西 崇弘、久保 正二, 他
    • Organizer
      第61回 日本消化器外科学会定期学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝細胞癌切除例における血清PIVKA-II測定の臨床的意義2006

    • Author(s)
      新川 寛二、久保 正二, 他
    • Organizer
      第61回 日本消化器外科学会定期学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C型肝炎関連肝細胞癌多中心性発生と 活動性肝炎および肝線維化2006

    • Author(s)
      久保 正二, 他
    • Organizer
      第61回 日本消化器外科学会定期学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2006-07-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝細胞癌切除例における術前PIVKA-II値と臨床病理所見,肝癌再発との関係2006

    • Author(s)
      新州 寛二、久保 正二, 他
    • Organizer
      第42回 日本肝癌研究会
    • Place of Presentation
      東京
    • Year and Date
      2006-07-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] B型肝炎関連肝細胞癌切除後癌再発に及ぼすlamivudine投与の効果2006

    • Author(s)
      久保 正二, 他
    • Organizer
      第42回 日本肝臓学会総会
    • Place of Presentation
      京都
    • Year and Date
      2006-05-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] MUC1発現肝細胞癌の臨床病理学的検討および臨床的意義2006

    • Author(s)
      市川 剛、久保 正二, 他
    • Organizer
      第42回 日本肝臓学会総会
    • Place of Presentation
      京都
    • Year and Date
      2006-05-26
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C型慢性肝炎インターフェロン完全著功後10年以上経過し発見された肝細胞癌の3切除例2006

    • Author(s)
      新川 寛二、久保 正二, 他
    • Organizer
      第18回 日本肝胆膵外科学会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-12
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C型肝炎関連肝細胞癌肝細胞癌多中心牲発生と活動性肝炎および肝線維化2006

    • Author(s)
      久保 正二, 他
    • Organizer
      第92回 日本消化器病学会総会
    • Place of Presentation
      北九州
    • Year and Date
      2006-04-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The prevalence of non-alcoholic steatohepatitis in surgical specimens of hepatocellular carcinoma in a Japanese university hospital2006

    • Author(s)
      Hai S, Kubo S, et. al.
    • Organizer
      American Hepato-Pancreato-Biliary Association
    • Place of Presentation
      Florida
    • Year and Date
      2006-03-09
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] C型肝炎患者における多中心性発癌の危険因子としての肝炎活動性と肝線維化2005

    • Author(s)
      久保 正二, 他
    • Organizer
      第16回 日本消化器癌発生学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2005-10-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] インターフェロン著効例からの肝発癌と潜在性ウィルス感染2005

    • Author(s)
      林 健博、久保 正二, 他
    • Organizer
      第9回 日本肝臓学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2005-10-05
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] B型肝炎関連肝細胞癌切除後成績に及ぼす肝炎ウィルス病態と抗ウィルス療法の問題点2005

    • Author(s)
      久保 正二, 他
    • Organizer
      第60回 日本消化器外科学会定期学術総会
    • Place of Presentation
      東京
    • Year and Date
      2005-07-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 尾状葉原発肝細胞癌に対する尾状葉切除術式の選択2005

    • Author(s)
      山本 隆嗣、久保 正二, 他
    • Organizer
      第30回 日本外科系連合学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2005-06-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝細胞癌におけるDNAメチル化プロファイル2005

    • Author(s)
      島田 昌幸、久保 正二, 他
    • Organizer
      第41 回日本肝臓学会
    • Place of Presentation
      大阪
    • Year and Date
      2005-06-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝細胞癌のstaging systemに対する肝炎ウィルス病態の影響2005

    • Author(s)
      久保 正二, 他
    • Organizer
      第41回 日本肝臓学会
    • Place of Presentation
      大阪
    • Year and Date
      2005-06-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] B型肝炎関連肝細胞癌手術におけるラミブジン投与の功罪2005

    • Author(s)
      久保 正二, 他
    • Organizer
      第105回目本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2005-05-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 肝切除可能なミラノ基準内肝細胞癌に対する生体部分肝移植の適応2005

    • Author(s)
      田中 宏、久保 正二, 他
    • Organizer
      第105回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2005-05-11
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 臨床・病理 原発性肝癌取扱い規約 2008年2月【第5版】2008

    • Author(s)
      日本肝癌研究会覧
    • Total Pages
      81
    • Publisher
      金原出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 臨床・病理 原発性肝癌取扱い規約2008年2月【第5版】2008

    • Author(s)
      日本肝癌研究会
    • Total Pages
      81
    • Publisher
      金原出版株式会社
    • Related Report
      2007 Annual Research Report
  • [Book] 別冊・医学のあゆみ 消化器疾患 state of arts II.肝・胆・膵 Ver.3 肝癌に対する術前経皮経肝門脈枝塞栓術2006

    • Author(s)
      久保 正二, 田中 宏
    • Total Pages
      726
    • Publisher
      医歯薬出版株式会社
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 別冊・医学のあゆみ 消化器疾患 state of arts II.肝・胆・膵 Ver.3 肝癌に対する術前経皮経肝門脈枝塞栓術2006

    • Author(s)
      久保正二, 田中 宏
    • Total Pages
      726
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2006 Annual Research Report
  • [Book] 消化器病学の進歩2005-モノグラフ- 胆肝膵編 生命予後・死因から見たC型肝炎関連肝細胞癌切除におけるインターフェロン治療の意義2005

    • Author(s)
      久保正二, 他
    • Publisher
      メディカルレビュー社
    • Related Report
      2005 Annual Research Report
  • [Book] 消化器病学の進歩2005-モノグラフ- ニューフロンティア編 組み込みHBV-DNAをプローブとした肝癌関連遺伝子のスクリーニング2005

    • Author(s)
      田守昭博, 久保正二, 他
    • Publisher
      メディカルレビュー社
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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