Genetic alteration of small adenomas prospectively observed after colorectal cancer surgery.

• Project/Area Number: 17591434
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Jichi Medical University
• Principal Investigator: TOGASHI Kazutomo Jichi Medical University, 医学部, 准教授 (10316531)
• Co-Investigator(Kenkyū-buntansha): MIYAKURA Yasuyuki 自治医科大学, 医学部, 講師 (50306122) ; 高田 理 自治医科大学, 医学部, 研究員 (50382924)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,620,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000); Fiscal Year 2005: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 大腸腺腫 / 大腸癌術後 / 大腸内視鏡検査 / マイクロアレイ / mRNA

Research Abstract

大腸癌術後患者の術後サーベイランス内視鏡において、、6mm以下の大腸ポリープ500病変が軽・中等度異型腺腫と内視鏡診断され、経過観察された。このうち412病変で内視鏡が実施され、腫瘍径・形態の経時的変化が評価された。腫瘍径の変化は、不変71%、増大15%、縮小3%、再発見不可11%であり、明らかな形態を示したものもほとんどなかった。

Research Products

• [Journal Article] Prospective observation of small adenomas in postc-olorectal-cancer surgery patients through magnification chromocolonoscopy. (2008)
  • Author(s): Togashi K, Shimura K, Konishi F, Miyakura Y, et al.
  • Journal Title: Dis Colon Rectum 51 Pages: 196-201
  • Peer Reviewed
• [Journal Article] Prospective observation of small adenomas in postcolorectal cancer surgery patients through magnification chromocolonoscopy (2008)
  • Author(s): Togashi K, et. al.
  • Journal Title: Diseases of Colon and Rectum 51(2) Pages: 196-201
  • Peer Reviewed
• [Journal Article] Prevalence of synchronous colorectal neopiasms detected by colonoscopy in patients with gastric cancer (2008)
  • Author(s): Saito S, Hosoya S, Togashi K, et. al.
  • Journal Title: Surgery Today 38 Pages: 20-25
  • Peer Reviewed
• [Journal Article] Acetic acid spray technique is effective for identifying adenomas covered with mucus. (2007)
  • Author(s): Togashi K, et. al.
  • Journal Title: Endoscopy 39 Pages: 923-923
  • Peer Reviewed
• [Journal Article] 異時性大腸癌を標的としたサーベイランス大腸内視鏡検査 (2006)
  • Author(s): 鯉沼広治,冨樫一智
  • Journal Title: 癌の臨床 52 Pages: 285-8
• [Journal Article] 異時性大腸癌を標的としたサーベイランス大腸内視鏡検査 (2006)
  • Author(s): 鯉沼広治, 冨樫一智
  • Journal Title: 癌の臨床 52 Pages: 285-288
• [Journal Article] The Use of Acetic Acid in Magnification Chromo-Colonoscopy for the Small Polyp (2006)
  • Author(s): K Togashi et al.
  • Journal Title: Endoscopy 38 Pages: 613-616
• [Journal Article] Magnification Chromo-colonoscopy (2006)
  • Author(s): K Togashi, F konishi
  • Journal Title: ANZ Journal of Surgery 76 Pages: 1101-1105
• [Journal Article] High Prevalence of Sessile Serrated Adenomas With BRAF Mutations : A Prospective Study of Patients Undergoing Colonoscopy (2006)
  • Author(s): KJ Spring, ZZ Zhao, R Karamatic, MD Walsh, VLJ Whitehall, T Pike, LA Simms, J Young, M James, GW Montgomery, M Appleyard, D Hewett, K Togashi, JR Jass, BA Leggett
  • Journal Title: Gastroenterology 131 Pages: 1400-1407
• [Journal Article] Frequent involvement of ras-signaling pathways in both polypoid-type and flat-type early-stage colorectal cancers. (2006)
  • Author(s): H Noda, Y Kato, H Yoshikawa, M Arai, K Togashi, H Nagai, F Konishi, Y Miki
  • Journal Title: J Exp Clin Cancer Res 25 Pages: 235-242
• [Journal Article] 拡大内視鏡の最前線 III 拡大内視鏡による質的診断 (1)酢酸染色の効果を中心に (2005)
  • Author(s): 冨樫一智, 河村裕, 佐々木潤一, 他5名
  • Journal Title: 早期大腸癌 9巻・3号 Pages: 141-145
• [Journal Article] Distribution of lymph node metastasis in T1 sigmoid colon carcinoma : should we ligate the inferior mesenteric artery? (2005)
  • Author(s): 河村裕, 櫻木雅子, 冨樫一智, 他3名
  • Journal Title: Scand J of Gastroenterology 40巻・7号 Pages: 858-861
• [Journal Article] Microsatellite instability caused by hMLH1 promoter methylation increase with tumor progression in right-sided sporadic colorectal cancer (2005)
  • Author(s): H Noda, Y Kato, M Arai, K Togashi他3名
  • Journal Title: Oncology 69巻・4号 Pages: 354-362
• [Presentation] 拡大観察により軽・中等度異型腺腫と診断された小ポリープ(6mm以下)の自然史、大腸癌術後例における検討 (2008)
  • Author(s): 志村国彦、冨樫一智、堀江久永
  • Organizer: 第94回日本消化器病学会総会(ワークショップ)
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-10
• [Presentation] Prospective observation of small adenomas through magnification colonoscopy in post colorectal cancer surgery patients through magnifcation chromoclonoscopy. (2007)
  • Author(s): Togashi K, et. al.
  • Organizer: Asian Federation of Coloproctology
  • Place of Presentation: 東京
  • Year and Date: 2007-09-22
• [Presentation] Prospective observation of small adenomas in post colorectal cancer surgery patients through magnification chromocolonoscopy. (2007)
  • Author(s): Togashi K, Shimura K, Konishi F, Miyakura Y et al.
  • Organizer: American Society of Colorectal Surgeons, Annual Meeting 2007 (Oral)
  • Place of Presentation: 米国 セントルイス
  • Year and Date: 2007-06-05
• [Presentation] Prospective observation of small adenomas in post colorectal cancer surgery patients through magnification chromocolonoscopy (2007)
  • Author(s): Togashi K, et. al.
  • Organizer: American Society of Colorectal Surgeons
  • Place of Presentation: St Louis,USA
  • Year and Date: 2007-06-05
• [Presentation] Prospective observation of small adenomas through magnification chromocolonoscopy in post-colorectal-cancer surgery patients. (2006)
  • Author(s): Togashi K, Shimura K, Konishi F, Miyakura Y et al.
  • Organizer: 14th The United European Gastroenterology Week
  • Place of Presentation: ドイツ ベルリン
  • Year and Date: 2006-10-24
• [Presentation] 大腸癌術後に発見される5mm以下の大腸腺腫の自然史 (2006)
  • Author(s): 志村国彦, 冨樫一智, 宮倉安幸, 他
  • Organizer: 第61回日本大腸肛門病学会総会 (口演)
  • Place of Presentation: 弘前
  • Year and Date: 2006-09-29
• [Book] 拡大観察により軽・中等度異型腺腫と診断された小ポリープ(6mm以下)の自然史、大腸癌術後例における検討
  • Author(s): 志村国彦、冨樫一智、堀江久永
  • Publisher: 第94回日本消化器病学会総会記念誌
  • Description: (in print)