| Project/Area Number |
17591438
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Teikyo University |
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Principal Investigator |
IKEDA Yoshifumi Teikyo University, Associate Professor, 医学部, 助教授 (20222870)
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| Co-Investigator(Kenkyū-buntansha) |
NIIMI Masanori Teikyo University, Associate Professor, 医学部, 助教授 (80198415)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | esophageal cancer / anastomosis / leakage / tissue blood flow / vasodilator / PGE1 / lipo-PGE1 / 胃管 / Layser-Doppler flowmetry法 / PGE1濃度 |
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| Research Abstract |
Introduction: Lipo-prostaglandin E1 (PGE1) is a new preparation of PGE1 in which it is bound to lipids in order to slow PGE1 release and delay its rate of metabolism. We investigated the change of the blood flow on impaired microcirculation of the ischemic gastric tube in pigs after saline, unmodified PGE1 and lipo-PGE1 administration.
Materials and Methods: The gastric tube was constructed using fifteen domestic pigs under general anesthesia, and saline, unmodified PGE1 and lipo-PGE1 were infused continuously at a rate of 0.05μg/kg/min for 10 minutes. Tissue blood flow (TBF) were analyzed before administration, after administration for 10 minutes, and until 120 minutes after the end of administration.
Results: There were no obvious changes in TBF during the administration of saline. However, TBF during treatment with unmodified PGE1 and lipo-PGE1 was significantly increased to 13.1 ± 1.3 and 13.5 ± 1.4 ml/min/100g, respectively (paired t-test; p<0.01). Although TBF was significantly decreased to 8.0 ± 1.0 ml/min/100g on 10 minutes after the end of unmodified PGE1 administration (paired t-test; p<0.01), it was maintained over 10 ml/min/100g until 120 minutes in lipo-PGE1 group.
Conclusion: Lipo-PGE1 infusion leads to the objectively measurable improvement and the prolonged action in the blood perfusion of the gastric tube in pigs. Therefore, treatment with lipo-PGE1 infusion can increase TBF at the anastomotic site, and it may be beneficial for preventing anastomotic leakage in boluses for a couple of times a day.
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