| Project/Area Number |
17591439
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Tokai University |
|---|
Principal Investigator |
SOTARO Sadahiro Tokai University, 医学部, Professor (40138029)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MURAYAMA Chieko Tokai University, 医学部, Associate Professor (50307295)
SUZUKI Toshiyuki Tokai University, 医学部, Associate Professor (80276823)
ISHIKAWA Kenji Tokai University, 医学部, Assistant Professor (80287078)
|
|---|
| Project Period (FY) |
2005 – 2007
|
| Project Status |
Completed (Fiscal Year 2007)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
|
|---|
| Keywords | rectal cancer / chemoradiotherapy / proenostic factor / 放射線療法 / 感受性因子 / 放射線治療 / 化学放射線治療 / 増感剤 |
|---|
| Research Abstract |
Background/Aims : Predictors of sensitivity to preoperative radiotherapy (RT) may differ from those of chemo-radiotherapy(CRT) . This study attempts to evaluate retrospectively the significance of apoptosis-related and proliferative indexes in biopsy specimens obtained before treatment as predictors of sensitivity to RT or to CRT for locally advanced rectal adenocarcinoma.
Methods : The subjects were 96 patients with clinical T3-4/N_x/M0 adenocarcinoma of the middle third or lower third of the rectum. Sixty-one patients were treated with preoperative RT alone (20 Gy in 10 fractions) [RT group]during 1991-1998, and 35 patients received concurrent oral tegafur/uracil (UFT) [CRT group]since 1999. Radical surgery including THE and pelvic nerve preservation with 15 Gy of intraoperative RT was performed two weeks after completion of the preoperative radiation. We evaluated apoptotic index(AI)and p53, p21 and Ki-67 protein expression in the biopsy specimens, and histological differentiation, pathologic regression in the resected specimens and the degree of tumor shrinkage based on the double contrast barium enema images.
Results : AI-positivity, p53-negativity, p21-positivity and well differentiated adenocarcinoma were predictors of high sensitivity in RT group, whereas AI-positivity alone was the predictor in CRT group. The addition of UFT to RT increased sensitivity in patients with p53-positivity, p21-negativity and moderately differentiated adenocarcinoma.
Conclusions : Predictors of sensitivity are different between RT and CRT.
|
