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Optimal preoperative chemoradiotherapy for rectal cancer

Research Project

Project/Area Number 17591439
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionTokai University

Principal Investigator

SOTARO Sadahiro  Tokai University, 医学部, Professor (40138029)

Co-Investigator(Kenkyū-buntansha) MURAYAMA Chieko  Tokai University, 医学部, Associate Professor (50307295)
SUZUKI Toshiyuki  Tokai University, 医学部, Associate Professor (80276823)
ISHIKAWA Kenji  Tokai University, 医学部, Assistant Professor (80287078)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsrectal cancer / chemoradiotherapy / proenostic factor / 放射線療法 / 感受性因子 / 放射線治療 / 化学放射線治療 / 増感剤
Research Abstract

Background/Aims : Predictors of sensitivity to preoperative radiotherapy (RT) may differ from those of chemo-radiotherapy(CRT) . This study attempts to evaluate retrospectively the significance of apoptosis-related and proliferative indexes in biopsy specimens obtained before treatment as predictors of sensitivity to RT or to CRT for locally advanced rectal adenocarcinoma.
Methods : The subjects were 96 patients with clinical T3-4/N_x/M0 adenocarcinoma of the middle third or lower third of the rectum. Sixty-one patients were treated with preoperative RT alone (20 Gy in 10 fractions) [RT group]during 1991-1998, and 35 patients received concurrent oral tegafur/uracil (UFT) [CRT group]since 1999. Radical surgery including THE and pelvic nerve preservation with 15 Gy of intraoperative RT was performed two weeks after completion of the preoperative radiation. We evaluated apoptotic index(AI)and p53, p21 and Ki-67 protein expression in the biopsy specimens, and histological differentiation, pathologic regression in the resected specimens and the degree of tumor shrinkage based on the double contrast barium enema images.
Results : AI-positivity, p53-negativity, p21-positivity and well differentiated adenocarcinoma were predictors of high sensitivity in RT group, whereas AI-positivity alone was the predictor in CRT group. The addition of UFT to RT increased sensitivity in patients with p53-positivity, p21-negativity and moderately differentiated adenocarcinoma.
Conclusions : Predictors of sensitivity are different between RT and CRT.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (13 results)

All 2007 2006

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] Predictors of tumor downsizing and regression with preoperative radiotherapy alone and with concomitant tegafur/uracil(UFT) for resectable advanced rectal adenocarcinoma2007

    • Author(s)
      Sadahiro S, et. al.
    • Journal Title

      Hepato-Gastroenterology 54

      Pages: 1107-1112

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Predictors of tumor downsizing and regression with preoperative radiotherapy alone and with concomitant tegafur/uracil(UFT) for resectable advanced rectal adenocarcinoma2007

    • Author(s)
      Sadahiro, S., Suzuki, T., Maeda, Y., et. al.
    • Journal Title

      Hepato-Gastroenterology 54

      Pages: 1107-1112

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Predictors of tumor downsizing and regression with preoperative radiotherapy alone and with concomitant tegafur/uracil for resectable advanced rectal adenocarcinoma2007

    • Author(s)
      Sadahiro, S, et. al.
    • Journal Title

      Hepatogastroenterology 54

      Pages: 1107-1112

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 直腸癌に対する放射線/化学放射線療法2006

    • Author(s)
      貞廣荘太郎, 村山千恵子, 他
    • Journal Title

      臨床放射線 51(3)

      Pages: 353-360

    • Related Report
      2006 Annual Research Report
  • [Journal Article] T3/T4中下部直腸腺癌に対する術前化学放射線+術中電子線併用療法の成績と至適術前レジメンの検討2006

    • Author(s)
      貞廣荘太郎, 鈴木俊之, 他
    • Journal Title

      癌の臨床 52(5)

      Pages: 371-375

    • Related Report
      2006 Annual Research Report
  • [Presentation] T3/T4中下部直腸腺癌に対する術前放射線/化学療法+術中電子線併用治療の成績と今後の展望2007

    • Author(s)
      貞廣 荘太郎
    • Organizer
      第107回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 直腸癌に対する化学放射線治療の組織学的効果予測因子の検討2007

    • Author(s)
      鈴木 俊之
    • Organizer
      第45回日本癌治療学会総会
    • Place of Presentation
      京都
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Preoperative chemoraiotherapy with IORT for T3/T4 adenocarcinoma of the rectum2007

    • Author(s)
      Sadahiro, S., et. al.
    • Organizer
      107th Annual meeting of Japan Surgical Society
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Prognostic factor for patients treated with preoperative chemoradiotherapy2007

    • Author(s)
      Suzuki, T., Sadahiro, S., et. al.
    • Organizer
      45th Annual meeting of Japan Society of Clinical Oncology
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] T3/T4中下部直腸腺癌に対する術前放射線+術中電子線併用治療の成績と術前レジメンの検討2006

    • Author(s)
      貞廣 荘太郎
    • Organizer
      第106回日本外科学会定期学術集会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 中下部進行直腸腺癌に対する術前化学放射線治療における内視鏡所見と組織学的効果の検討2006

    • Author(s)
      鈴木 俊之
    • Organizer
      第44回日本癌治療学会総会
    • Place of Presentation
      東京
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Preoperative chemoraiotherapy with IORT for T3/T4 adenocarcinoma of the lower two-thirds of the rectum2006

    • Author(s)
      Sadahiro, S., Suzuki, T., Maeda, Y., et. al.
    • Organizer
      106th Annual meeting of Japan Surgical Society
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Endoscopic and histologic assessment of preoperative chemoradiotherapy for rectal cancer2006

    • Author(s)
      Suzuki, T., Sadahiro, S., et. al.
    • Organizer
      44th Annual meeting of Japan Society of Clinical Oncology
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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