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Significance of ubiquitin-conjugating enzyme in esophageal cancer

Research Project

Project/Area Number 17591442
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionJIKEI UNIVERSITY

Principal Investigator

ISHIBASHI Yoshio  Jikei University, School of Medicine, Lecturer, 医学部, 講師 (00246373)

Co-Investigator(Kenkyū-buntansha) TAKADA Koji  Jikei University, School of Medicine, Associate Professor, 医学部, 助教授 (30179452)
KOBAYASHI Katsutoshi  Jikei University, School of Medicine, Research Assistant, 医学部, 助手 (60343547)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsEsophageal Cancer / Ubiquitin / ubiquitin-conjugating enzyme / ユビキチン結合酵素 / Ubc10
Research Abstract

Purpose : To screen key molecules to aid the prediction of prognosis in esophagealcancer, we previously carried out and reported gene-expression profiling : we found that RNA expressions of ubiquitin-conjugating enzymes were upregulated in patients with a poor outcome. Therefore, we focused on ubiquitin-conjugating enzyme H10 (UbcH10) which is indispensable the cell-cycle transition from metaphase to anaphase, and investigated whether this protein expression levels of UbcH10 in cancerous esophageal lesions affected the prognosis of patients with esophageal squamous cell carcinoma by evaluating more patients for a longer period.
Experimental Design : Paraffin-embedded tissue samples from 121 patients with esophageal squamous cell carcinoma were stained with anti-UbcH10 antibody for immunohistochemical analysis.
Results : UbcH10 was expressed in cancerous and dysplastic lesions, but not in normal tissue. Depending on the staining pattern, patients were grouped according to expression : high (N=33) or low (N=88). There were significant differences between the groups in terms of invasion into lymphatic vessels, number of metastatic lymph nodes, TNM classification, and stages as well as survival: the 50% survival rate in the high expression group was 2.3 years, as compared with 9.9 years for the low expression group (P<0.0001). Even with multi-variate adjusting for stage 0 to stage IV using the Cox proportional hazard model, patients belonging to the high-expression group had a poorer prognosis (HR:2.5;95% Cl:1.3-4.5;P=0.004).
Conclusions : High UbcH10 protein expression seems to be a novel poor prognosis in esophageal squamous cell carcinoma.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (6 results)

All 2007 2006

All Journal Article (6 results)

  • [Journal Article] Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3.2007

    • Author(s)
      Ueda K, Yamada K, Urashima M, Ishibashi Y et al.
    • Journal Title

      Oncol Rep. 17

      Pages: 731-735

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Association of extracellular matrix metalloproteinase inducer in endometrial carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3.2007

    • Author(s)
      Ueda K, Yamada K, Urashima M, Ishibashi Y, et al.
    • Journal Title

      Oncol Rep. Vol.17

      Pages: 731-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Association of extracellular matrix metalloproteinase inducer in endometrail carcinoma with patient outcomes and clinicopathogenesis using monoclonal antibody 12C3.2007

    • Author(s)
      Ueda K, Urashima M, Ishibashi Y et al.
    • Journal Title

      Oncol Rep. 17

      Pages: 731-5

    • Related Report
      2006 Annual Research Report
  • [Journal Article] xpression of vascular endothelial growth factor (VEGF)-C and -D in gastric carcinoma.2006

    • Author(s)
      Shida A, Fujioka S, Kobayashi K, Ishibashi Y, et al.
    • Journal Title

      Int J Clin Oncol. 11

      Pages: 38-43

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of vascular endothelial growth factor (VEGF)-C and-D in gastric carcinoma.2006

    • Author(s)
      Shida A, Fujioka S, Kobayashi K, Ishibashi Y, et al.
    • Journal Title

      Int J Clin Oncol. Vol.11

      Pages: 38-43

    • NAID

      10020572279

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of vascular endothelial growth factor (VEGF)-C and -D in gastric carcinoma.2006

    • Author(s)
      Shida A, Fujioka S, kobayashi K, Ishibashi Y, et al.
    • Journal Title

      Int J Clin Oncol. 11

      Pages: 38-43

    • NAID

      10020572279

    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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