| Project/Area Number |
17591451
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
URAMOTO Hidetaka University of Occupational and Environmental Health, Japan, School of Medicine, Research Assistant, 医学部, 助手 (90389445)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIO Kenji University of Occupational and Environmental Health, Japan, School of Medicine, Assistant Professor, 医学部, 助教授 (70235927)
OYAMAT Sunehiro University of Occupational and Environmental Health, Japan, School of Medicine, Assistant Professor, 医学部, 助教授 (00309965)
HANAGIRI Takeshi University of Occupational and Environmental Health, Japan, School of Medicine, Assistant Professor, 医学部, 講師 (30299614)
MORITA Masaru Kyushu University, University Hospital, Assistant Professor, 大学病院, 講師 (30294937)
NOZOE Tadahiro School of Medicine, Assistant Professor, 医学部, 講師 (90325457)
菅谷 将一 産業医科大学, 医学部, 助手 (40352306)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,600,000 (Direct Cost: ¥2,600,000)
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| Keywords | esophageal cancer / lung cancer / smoking / alcohol / family history / aldehyde dehydrogenase / methylation / EGFR |
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| Research Abstract |
Alcohol metabolism: A loss of fragile histidine triad (FHIT) expression is associated not only with alcohol-induced esophageal carcinogenesis, but also with multicentric carcinogenesis, in the metabolic pathway of ethanol. Aldehyde dehydrogenase 2 (ALDH2) is a major enzyme for detoxification of acetaldehyde, and it is important for esophageal and ling carcinogenesis. Both inactive and active forms of ALDH2 are induced in the esophagus by heavy drinking and also support a hypothesis that ALDH2 deficiency might be a high-risk factor of esophageal cancer for the individuals having a heavy-drinking habit. The expression level of Cyp2e1 was increased in the liver from Aldh2-null mice. Therefore, Aldh2-null mice may be useful model animals for the investigation of alcohol metabolism and related diseases.
Tobacco smoking: The methylation of p16 was more frequently observed in patients who were heavy smoker and with squamous cell carcinoma and than in never/ light smokers and adenocarinoma, respectively. The mutations in the epidermal growth factor receptor (EGFR) gene were more frequently observed in patients who smoked p20 pack-year, and in patients who quit at least 20 years before the date of diagnosis for lung cancer. The K-ras mutations were more frequently found in smokers than in never smokers, and in high-dose smokers than in low-dose smokers, suggesting that mutations of EGFR and k-ras might be strongly associated with exposure of tobacco smoking.
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