| Project/Area Number |
17591464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Fukui |
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Principal Investigator |
MORIOKA Kouichi University of Fukui Hospital, Associate Professor, 医学部附属病院, 講師 (80210144)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Kuniyoshi University of Fukui, Faculty of Medical Sciences, Professor, 医学部, 教授 (70144251)
FUJIBAYASHI Yasuhisa University of Fukui, Biomedical Imaging Research Center, Professor, 高エネルギー医学研究センター, 教授 (50165411)
MURATA Tetsuhito University of Fukui, Faculty of Medical Sciences, Associate Professor, 医学部, 助教授 (80200294)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2005: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | Spinal cord protection / FDG / Thoracic aortic surgery / Cooling / 体外循環 |
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| Research Abstract |
We developed a new metabolism function analysis way using a fresh brain tissue slice of a rat and a positron sign compound (dynamic positron autoradiography technique, dPAT) in this research and were estimating. In particular we got a [18F] FDG bustle as two-dimensional image information to brain slice before and after a low oxygen load and a low oxygen with no glucose load.
We succeeded to make a section of a spinal cord using rats and dogs.
The difference between the spinal cord and the brain is elucidated, and it's considered whether the cerebroprotection effect and the spinal cord protection effect are partial.
The dPAT method cannot reproduce the complete ischemic spinal cord injury of in vivo. But operating the organization and temperature of the solution, it can change conditional setting, can analyze a characteristic of an obstacle for a multiple factor. There is a scientific feature and a creativity at this point. In the future, elucidation of occurrence mechanism of complicated ischemic spinal cord injury and development of the protection method are expected.
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