Analysis of coronary endothelial damage and other adverse effects during off-pump CABG
| Project/Area Number |
17591478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Saga University |
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Principal Investigator |
OKAZAKI Yukio Saga University, Faculty of Medicine, Thoracic and Cardiovascular Surgery, Associate Professor, 医学部, 助教授 (80203975)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Tsuyoshi Saga University, Faculty of Medicine, Thoracic and Cardiovascular Surgery, Professor, 医学部, 教授 (10110496)
SATOSHI SAtoshi Saga University, Faculty of Medicine, Thoracic and Cardiovascular Surgery, Assistant Professor, 医学部, 講師 (20291528)
FURUKAWA Kojiro Saga University, Faculty of Medicine, Thoracic and Cardiovascular Surgery, Assistant Professor, 医学部, 講師 (90264176)
HIRASE Tetsuaki Saga University, Faculty of Medicine, Cardiovascular and Renal Medicine, Assistant Professor, 医学部, 助手 (60363446)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 2005: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | coronary artery bypass grafting / coronary endothelium / less invasive surgery / mitral regurgitation / 冠動脈バイパス術 / NFκB |
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| Research Abstract |
Although off-pump coronary artery bypass grafting (CABG) has been recognized less invasive than conventional CABG on cardiopulmonary bypass, off-pump CABG may be partly invasive especially to the coronary endothelium. The present study was designed to evaluate the adverse effects related to off-pump CABG.
Coronary snaring resulted in coronary endothelial injury, which was ameliorated by using elastic sutures in stead of non-elastic sutures. Non-humidified gas insufflation made blood cells deposited and endothelial cells delaminated with time. Humidified gas insufflation attenuated these adverse effects. Heparin and dipyridamole-added humidification had potential advantage in terms of reducing deposited blood cells on the endothelium over simple humidification.
Regarding molecular biological adverse effects related to temporary clamping of the coronary artery, NF-kB was detected even in the short term ischemia in animal model of off-pump CABG. These analysis are still on going.
Mitral regurgitation (MR) during off-pump CABG, particularly focused on the mitral annular behavior, was also evaluated in dog by cardiac endoscopy and digital 3-D ultrasound sonomicrometer. Only cardiac displacement did not cause MR if coronary perfusion was maintained. Occlusion of LAD rarely caused MR from antero-lateral site. Occlusion of LCx usually caused MR from mainly postero-medial site with enlarged postero-medial annulus even with controlled LVEDP.
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Report
(3 results)
Research Products
(7 results)
