| Project/Area Number |
17591479
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
OSHIRO Masakatsu (2006-2007) University of the Ryukyus, Univ. of the Ryukyus Hospital, Assistant Professor (00315483)
川端 徹也 (2005) 琉球大学, 医学部附属病院, 助手 (30325857)
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| Co-Investigator(Kenkyū-buntansha) |
KAKINOHANA Manabu University of the Ryukyus, Faculty of Medicine, Associate Professor (20274897)
SAIKAWA Satoko University of the Ryukyus, Univ. of the Ryukyus Hospital, Assistant professor (20404569)
大城 匡勝 琉球大学, 医学部附属病院, 助手 (00315483)
笹良 剛史 琉球大学, 医学部附属病院, 助手 (80225903)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,740,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | spinal cord ischemia / SEP / MEP / HFO analysis / paraplegia / Aortic surgery / 脊髄機能モニタリング / 運動誘発電位 / 脊髄運動神経細胞 / プロポフォール |
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| Research Abstract |
The aim of this project was to investigate whether High frequency analysis of Somatosensory evoked potentials (SEP) can provide excellent efficacy for detecting the spinal cord ischemia during aortic cross clamping. Using the rat's spinal cord ischemic model, transcranial motor evoked potential monitoring can detect the spinal cord ischemia within 2min after aortic cross clamp, which was much faster to detect spinal cord ischemia than that by somatosensory evoked potentials. According to high frequency analysis of SEP, high frequency of analysis of SEP did not reflect spinal cord function, but supraspinal function. Therefore, our conclusion was that high frequency analysis of SEP could not be new spinal cord functional monitoring for aortic surgery. However, in this project, we found that transcranial motor evoked potentials monitoring can provide rapid detection for spinal cord ischemia after aortic occlusion, and the P50_<MEP> and P50_<SCEP> which represent the interval of aortic occlusion associated with 50 % probability of assessment of ischemic spinal cord dysfunction by MEP and SCEP were 0.3+/- 0.1 min and 6.2+/- 0.5 min, respectively.
Our data indicated that tc-MEP monitoring could detect the onset of spinal cord ischemia so rapidly in comparison with segmental SCEP monitoring, which could provide therapeutic windows in a surgical approach that includes spinal cord protection.
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