Development of NADH fluorescence imaging system for in vivo model
| Project/Area Number |
17591485
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Iwate Medical University |
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Principal Investigator |
FUKUHIRO Yoshiaki Iwate Medical University, School of Medicine, Assistant, 医学部, 助手 (20228927)
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| Co-Investigator(Kenkyū-buntansha) |
OGASAWARA Yasuo Kawasaki Medical School, Associate Professor, 医学部, 助教授 (10152365)
MOCHIZUKI Seiichi Kawasaki Collage of Allied Health Profession, Associate Professor, 臨床工学科, 助教授 (60259596)
KAWAZOE Kouhei Iwate Medical University, School of Medicine, Professor, 医学部, 教授 (50075561)
ISHIHARA Kazuaki Iwate Medical University, School of Medicine, Associate Professor, 医学部, 助教授 (30119888)
ENDO Shigeatsu Iwate Medical University, School of Medicine, Professor, 医学部, 教授 (30160394)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | NADH fluorescence / image / in vivo model / myocardial ischemia / 循環器・高血圧 / 生理学 / 分析化学 / 可視可 / 外科 |
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| Research Abstract |
Myocardial NADH fluorescence image reflects the myocardial energy metabolism and also indicates the myocardial redox state. We newly developed a fluorescence CCD system in vivo model and evaluated a performance in the rat heart model. During myocardial global ischemia, the intensity of NADH fluorescence on epicardium rapidly increased and reached plateau level within 60 seconds after ischemia. We successfully visualized the intensity change of NADH fluorescence real timely during myocardial ischemia and this system could be introduced to evaluate the change of myocardial NADH fluorescence during myocardial ischemia in vivo model.
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Report
(3 results)
Research Products
(2 results)
