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Introduction of prostacyclin synthase gene for treatment of cerebral vasospasm

Research Project

Project/Area Number 17591500
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionGunma University

Principal Investigator

YOSHIDA Takaaki  Gunma University, Faculty Medicine, Assistant Professor (40375572)

Co-Investigator(Kenkyū-buntansha) SAITO Nobuhito  Tokyo University, Hospitoal, Professor (60262002)
TAKAHASHI Akio  Gunma University, Faculty of Medicine, Associate Professor (60261856)
IMAI Hideaki  Gunma University, Faculty of Medicine, Assistant Professor (70359587)
KAZAMA Ken  Gunma University, Graduete school of Medicine, Assistant Professor (30396626)
SUZUKI Tomonari  Saitama Medical University, Schcol of Medicine, Assistant Professor (50361374)
登坂 雅彦  群馬大学, 大学院・医学系研究科, 助手 (40323357)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,610,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2006: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2005: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywordssubarachnoid hemorrhege / cerebral vasospasm / ischemic tention recording / Prostacyclin / subarachnoid hemorrahge / isometric tension recording
Research Abstract

Cerebral vasospasm is a severe complication of subarachnoid hemorrhage that frequently arises after rupture of a cerebral aneurysm, but the pathogenesis is still unclear. Cerebral vasospasm is a unique clinical phenomenon characterized by the delayed and prolonged contraction of the major cerebral arteries. subarachnoid hemorrhage causes dysfunction of endothelium, and inhibition of endothelium-derived relaxing factor. Then, restoration of endothelium derived relaxing factor may treat the phenomenon. The representative endothelium-derived relaxing factor is NO. Introduction of NO synthetase gene treat cerebral vasospasm in experimental SAH model. We paid attention to another endothelium-derived relaxing factor, prostacycline (PGI2), and tested pharmacological effect of PGI2 (beraprost sodium) using isometric tension recording. The beraprost sodium could not inhibit the contraction induced by high dose potassium (80mM). And, that could not inhibit the contraction induced by 100 μmol/L norepinephrine, too. The beraprost sodium 10, 100 μmol/L, 1 mmol/L could inhibit the contraction induced by 10 μmol/L PGF2α, dose-dependently. However, the contractile inhibition effect of beraprost sodium might not be sufficient for the treatment of cerebral vasospasm after SAH. Then, We thought it difficult that introduction of PGI2 synthetase gene had a great inihibitory effect to the severe cerebral vasoconstriction after SAH. PGI2 may have a possibility to be new therapeutic agent for cerebral vasospasm, however the further studies were required.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (7 results)

All 2007 2006 2005

All Journal Article (7 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] IC ligation及びbypass術を施行した海綿静脈洞部内頚動脈瘤の術後MRIの検討2007

    • Author(s)
      吉田 貴明
    • Journal Title

      日本脳神経CI学会機関誌 CI研究 28巻3-4

      Pages: 119-125

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] MRI Findings of Carotid Cavernous Aneurysms Treated by IC Ligation and Bypass Surgery2007

    • Journal Title

      Progress in computed imaging Vol. 28 No. 3-4

      Pages: 119-125

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] IC ligation及びbypass術を行した海綿静脈洞部頚動脈瘤の術後MRIの検討2007

    • Author(s)
      吉田 貴明
    • Journal Title

      日本脳神経CI学会機関誌 CI研究 283-284

      Pages: 119-125

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IC ligation及びbypass術を施行した海綿静脈洞部内頚動脈瘤の術後MRIの検討2007

    • Author(s)
      吉田 貴明
    • Journal Title

      日本脳神経CI学会機関誌 CI研究 28巻3号 (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] A new model of focal cerabral ischemia in the miniature pig.2006

    • Author(s)
      Imai H, etc.
    • Journal Title

      Journal of Neurosurgery 104(2)

      Pages: 123-132

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Wave-like appearance of diffuse pachymeningeal enhancement associated with intracranial hypotension.2005

    • Author(s)
      Tosaka M, etc.
    • Journal Title

      Neuroradiology 47

      Pages: 362-367

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Incidentally detected parafalcine chondrosarcoma.2005

    • Author(s)
      Tosaka M, etc.
    • Journal Title

      Acta Neurochirurgica(Wien) 147

      Pages: 795-799

    • Related Report
      2005 Annual Research Report

URL: 

Published: 2005-04-01   Modified: 2016-04-21  

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