| Project/Area Number |
17591502
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAMADA Kyousuke The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 特任講師 (80372374)
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| Co-Investigator(Kenkyū-buntansha) |
MASUTANI Yoshitaka The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (20345193)
TAKEUCHI Fumiya The University of Hokkaido, Faculty of Medicine, Assistant Professor, 医学部, 助教授 (30281835)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
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| Keywords | magnetoencephalography / functional MRI / functional brain mapping / language function / neuronavigation system |
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| Research Abstract |
It is known that functional magnetic resonance imaging(fMRI) and magnetoencephalography(MEG) are sensitive to the frontal and temporal language function, respectively.. We, therefore, established combined utilization of fMRI and MEG to make reliable identification of the global language dominance in the pathological brain conditions. We investigated 117 patients with brain lesions whose language dominance was successfully confirmed by the Wada test. All patients were asked to generate verbs related to acoustically presented nouns(verb generation) for fMRI and to read 3-letter words for fMRI and MEG. fMRI typically showed prominent activations in the inferior and middle frontal gyri, whereas calculated dipoles on MEG typically clustered in the superior temporal region and the fusiform gyrus of the dominant hemisphere. A total of 87 patients were further analyzed using useful data from both the combined method and the Wada test. Remarkably, in the 87 patients, we observed a 100% match of the combination method results on the language dominance with the Wada test results, including the two cases that showed expressive and receptive language areas dissociated into bilateral hemispheres. In order to confirm localization of language-fMRI and -MEG, we used electrical cortical stimulation(ECS) with subdural electrodes in 13 patients with intractable epilepsy. ECS to the inferior frontal love including fMRI activation demonstrated speech arrest, while ECS to fusiform gyrus and superior temporal region caused dyslexia. The results demonstrate that this non-invasive and repeatable method is not only highly reliable in determining the language dominance, but can also locate the expressive and receptive language areas separately. The method may be a potent alternative to invasive procedures of the Wada test, and useful in treating patients with brain lesions.
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