| Project/Area Number |
17591512
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
HIRATA Masayuki Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (30372626)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOSHIMINE Toshiki Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (00201046)
KATO Amami Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (00233776)
YORIFUJI Shiro Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (80191675)
KAZUI Hiromitsu Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (30346217)
KISHIMA Haruhiko Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (10332743)
|
|---|
| Project Period (FY) |
2005 – 2006
|
| Project Status |
Completed (Fiscal Year 2006)
|
| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,500,000 (Direct Cost: ¥2,500,000)
|
|---|
| Keywords | language function / functional restoration / cerebral oscillation / magnetoencephalography / subdural electrode / transcranial magnetic stimulation |
|---|
| Research Abstract |
[1] Establishment of noninvasive identification of language localization and comparison with invasive methods
1) Noninvasive determination of language localization using synthetic aperture magnetometry
We applied a voluntary speech task in addition to a silent reading task. Difference of oscillatory changes by different tasks were investigated. Comparison between kana reading and kanji reading indicated that kanji reading showed stronger desynchronization in the temporooccipital base.than kana reading (Hirata, Risho Noha, 2006). Emotional connotation in words was investigated. Emotional words indicated more prominent desynchronization in the prefrontal cortex and cingulate cortex. Lateralization of the prefrontal desynchronization was reversal between negative and positive emotional words. In addition, Emotional words indicated increased desynchronization in the inferior frontal cortex (Hirata, Neurolmage, 2007).
2) Comparison with chronic subdural electrodes and intraoperative cortical stimulation during awake surgery
Validation study indicated that language localization was well detectable with synthetic aperture magnetometry and the present silent reading task (Hirata, Biomag 2006 and ICCN 2006).
[2] Spatiotemporal analyses of local cerebral oscillatory changes induced by language activities
Group analyses of MEG was introduced to establish the normal standard of oscillatory changes induced by silent reading task ( in preparation).
[3] Evaluation of language function using transcranial magnetic stimulation
Evaluation will be performed after the approval by the hospital ethical committee
[4] Restoration of language function using brain computer interface
Spatiotemporal distribution of the categorized words is being investigated. Feasibility of the restoration of language function was assessed by discrimination analyses using support vector machine
|
