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Neuronal re-organization and functional recovery following activity dependent BDNF upregulation

Research Project

Project/Area Number 17591522
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionOita University

Principal Investigator

FUJIKI Minoru  Oita University, Department of Neurosurgery, School of Medicine, Professor (90231563)

Co-Investigator(Kenkyū-buntansha) HIKAWA Takamitsu  Oita University, Dept. of Neurosurgery, School of Medicine, Assistant Professor (20238257)
KUBO Takeshi  Oita University, Dept. of Neurosurgery, School of Medicine, Assistant Professor (80404375)
上田 徹  大分大学, 医学部, 講師 (90315333)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,480,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2006: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2005: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsCerebral ischemia / Neuronal death / Preconditioning / Magnetic stimulation / Gene expression / BDNF / Neuroprotection / Neuronal reorganization / 脊髄損傷
Research Abstract

Object. The present study demonstrates that repetitive transcranial magnetic stimulation (rTMS) induces ischemic tolerance against delayed neuronal death (DND) of hippocampal neurons following an otherwise lethal ischemic insult.
Methods. Various regimens of rTMS were delivered to adult gerbils at various times prior to an episode of ischemia induced by transient(5min.) bilateral common carotid artery occlusion(BCCO). The extent of delayed neuronal death in the CA1 region of the hippocampus was assessed quantitatively 7 days after the transient ischemic episode.
We will evaluate whether when rTMS will delivered 2-5 days prior to BCCO, delayed neuronal death will be substantially attenuated as reported in ischemic tolerance. We will evaluate the degree of neuroprotection by BDNF upregulation in the animals in the group that was stimulated 2 days prior to BCCO, whether neuron density in the CA1 sector was significantly higher in the rTMS pretreatment group than in the ischemia-only group. A similar degree of neuron sparing will be seen when stimulation was delivered 3, 4, or 5 days prior to BCCO. Effectiveness of rTMS was evaluated whether when stimulation was delivered at frequencies of 25 and 50 Hz. We will also evaluate whether stimulation at 25 Hz stimulation for 128 seconds(3200 pulses) is more effective than stimulation at 50 Hz for 64 seconds(3200 pulses) or 128 seconds(6400 pulses). Clinical application will be performed after hardware spec-up with ethical committee approve.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (31 results)

All 2007 2006 2005 Other

All Journal Article (22 results) (of which Peer Reviewed: 7 results) Presentation (3 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Navigated Brain Stimulation for Preoperative Anatomic and Functional Identification of Impaired Motor Cortex in a Patient With Meningioma2007

    • Author(s)
      Fujiki M, Hikawa T, Abe T, Anan M, Sugita K, Kobayashi H
    • Journal Title

      Neurosurgery Quarterly 17

      Pages: 33-39

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Neuroprotective and antiamnesic effect of donepezil,a nicotinic acetyl choline-receptor activator,on concessive mild traumatic brain injury in rats2007

    • Author(s)
      Fujiki M, Kubo T, Kamida T, Sugita K, Hikawa T, Abe T, Ishii K, Kobayashi H.
    • Journal Title

      J Clin Neurosci. 14

      Pages: 1240-1245

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Geranylgeranylacetone limits secondary injury,neuronal death,and proegrssive necrosis and cavitation after spinal cord inijury2007

    • Author(s)
      Fujiki M
    • Journal Title

      J Neurotrauma 30

      Pages: 15-20

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Intraoperative corticomuscular motor evoked potentials for evaluation of motor function:a comparison with corticospinal D and I waves2007

    • Author(s)
      Fujiki M
    • Journal Title

      J Neurosurg. 104

      Pages: 85-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Navigated Brain Stimulation for Preoperative Anatomic and Functional Identification of Impaired Motor Cortex in a Patient With Meningioma2007

    • Author(s)
      Fujiki, M., Hikawa, T., Abe, T., Anan, M., Sugita, K., Kobayashi, H.
    • Journal Title

      Neurosurgery Quarterly 17

      Pages: 33-39

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Neuroprotective and antiamnesic effect of donepezil, a nicotinic acetylcholine-receptor activator, on concussive mild traumatic brain injury in rats2007

    • Author(s)
      Fujiki, M., Kubo, T., Kamida, T., Sugita, K., Hikawa, T., Abe, T., Ishii, K., Kobayashi, H.
    • Journal Title

      J Clin Neurosci 14

      Pages: 1240-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Geranylgeranylacetone limits secondary injury, neuronal death, and progressive necrosis and cavitation after spinal cord injury2007

    • Author(s)
      Fujiki, M.
    • Journal Title

      J Neurotrauma 30

      Pages: 15-20

    • NAID

      10031136369

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Intraoperative corticomuscular motor evoked potentials for evaluation of motor function : a comparison with corticospinal D and I waves2007

    • Author(s)
      Fujiki, M., Furukawa, Y., Kamida, T., Anan, M., Inoue, R., Abe, T., Kobayashi, H.
    • Journal Title

      J Neurosurg 104

      Pages: 85-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Navigated Brain Stimulation for Preoperative Anatomic and Functional Identification of Impaired Motor Cortex in a Patient With Meningioma.2007

    • Author(s)
      Fujiki M, Hikawa T, Abe T, Anan M, Sugita K, Kobayashi H
    • Journal Title

      Neurosurgery Quarterly. 17

      Pages: 33-39

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective and antiamnesic effect of donepezil, a nicotinic acetylcholine-receptor activator, on concussive mild traumatic brain injury in rats.2007

    • Author(s)
      Fujiki M, Kubo T, Kamida T, Sugita K, Hikawa T, Abe T, Ishii K, Kobayashi H.
    • Journal Title

      J Clin Neurosci. 14

      Pages: 1240-5

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Geranylgeranylacetone limits secondary injury, neuronal death, and progressive necrosis and cavitation after spinal cord injury.2007

    • Author(s)
      Fujiki M
    • Journal Title

      J Neurotrauma 30

      Pages: 15-20

    • NAID

      10031136369

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraoperative corticomuscular motor evoked potentials for evaluation of motor function :.2006

    • Author(s)
      Fujiki M, Furukawa Y, Kamida T, Anan M, Inoue R, Abe T, Kobayashi H
    • Journal Title

      J Neurosurg. 104

      Pages: 85-92

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Garanylgeranylacetone, a noninvasive heat shock protein inducer, induces protein kinase C and leads to neuroprotection against cerebral infarction in rats.2006

    • Author(s)
      Uchida S, Fujiki M, Nagai Y, Abe T, Kobayashi H.
    • Journal Title

      Neurosci Lett. 396

      Pages: 220-224

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of protein kinase C in neuroprotective effect of geranylgeranylacetone, a noninvasive inducing agent of heat shock protein, on delayed neuronal death caused by trancient ischemia in rats.2006

    • Author(s)
      Fujiki M, Hikawa T, Abe T, Uchida S, Morishige M, Sugita K, Kobayashi H.
    • Journal Title

      J Neurotrauma. 23

      Pages: 1164-1178

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Reduced short latency afferent inhibition in diffuse axonal injury patients with memory impairment.2006

    • Author(s)
      Fujiki M, Hikawa T, Abe T, Ishii K, Kobayashi H.
    • Journal Title

      Neurosci Lett. 405

      Pages: 226-230

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Induced angiogenesis under cerebral ischemia by cyclooxygenase 2 and hypoxia inducible factor naked DNA in a rat indirect-bypass model2006

    • Author(s)
      Anan M, Abe T, Matsuda T, Ishii K, Kamida T, Fujiki M, Kobayashi H
    • Journal Title

      Neurosci Lett. 409

      Pages: 118-123

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neuroprotective effect of donepezil, a nicotinic acetylcholine-receptor activator, on cerebral infarction in rats.2005

    • Author(s)
      Fujiki M, Kobayashi H, Uchida S, Inoue R, Ishii K.
    • Journal Title

      Brain Res. 1043

      Pages: 236-241

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Geranylgeranylacetone limits secondary injury, neuronal death, and progressive necrosis and cavitation after spinal cord injury.2005

    • Author(s)
      Fujiki M, Furukawa Y, Kobayashi T, Abe T, Ishii K, Uchida S
    • Journal Title

      Brain Res 1053

      Pages: 175-184

    • NAID

      10031136369

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Anxiolytic suppression of repetitive transcranial magnetic stimulation-induced anxiety in the rats.2005

    • Author(s)
      Isogawa K, Fujiki M, Akiyoshi J, Tsutsumi T, Kodama K
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 29

      Pages: 664-668

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Neuroprotective effect of geranylgeranylacetone, a noninvasive heat shock protein inducer, on cerebral infarction in rats.2005

    • Author(s)
      Nagai Y, Fujiki M, Inoue R, Uchida S, Abe T, Kobayashi H
    • Journal Title

      Neurosci Lett. 374

      Pages: 183-188

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Hypoxia-Inducible factor-1a DNA Induced angiogenesis in a rat cerebral Ischemic model.2005

    • Author(s)
      Matsuda T, Abe T, Wu JL, Fujiki M, Kobayashi H
    • Journal Title

      Neurol Res. 27

      Pages: 503-508

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Mutant- I? Basuppresses hypoxia-induced VEGF expression through down-regulation of HIF-1a and COX-2 in human glioma cells.2005

    • Author(s)
      Kimba Y, Abe T, Wu JL, Inoue R, Fujiki M, Kobayashi H
    • Journal Title

      Oncol Res 15

      Pages: 139-149

    • Related Report
      2005 Annual Research Report
  • [Presentation] International TMS Multisite Study;Planning and design2007

    • Author(s)
      Fujiki M.
    • Organizer
      International Society for TMS
    • Place of Presentation
      Glasgow,UK
    • Year and Date
      2007-09-02
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] International TMS Multisite Study ; Planning and design2007

    • Author(s)
      Fujiki, M.
    • Organizer
      International Society for TMS
    • Place of Presentation
      Glasgow, UK
    • Year and Date
      2007-09-02
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] International TMS Multisite Study; Planning and design2007

    • Author(s)
      Fujiki M.
    • Organizer
      International Society for TMS
    • Place of Presentation
      Glasgow, UK,
    • Year and Date
      2007-09-02
    • Related Report
      2007 Annual Research Report
  • [Book] Magnetic Stimulation, In : Magnetism in Medicine : a handbook-2nd ed2006

    • Author(s)
      Ueno S, Fujiki M
    • Total Pages
      551
    • Publisher
      WILEY-VCH, New York,
    • Related Report
      2006 Annual Research Report
  • [Book] Plasticity in the Descending Motor Pathways after Spinal Cord Hemisection2005

    • Author(s)
      Fujiki M, Kobayashi H, Inoue R, Abe T, Ishii K
    • Total Pages
      389
    • Publisher
      Elsevier B.V.Amsterdam, Netherlands,
    • Related Report
      2005 Annual Research Report
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.med.oita-u.ac.jp/neurosurgery/index.html

    • Related Report
      2007 Final Research Report Summary
  • [Remarks]

    • URL

      http://www.med.oita-u.ac.jp/neurosurgery/index.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 脳神経外科術中運動野同定・機能的ナビゲーションシステム2007

    • Inventor(s)
      藤木 稔
    • Industrial Property Rights Holder
      藤木 稔
    • Industrial Property Number
      2007-303696
    • Filing Date
      2007-10-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Patent(Industrial Property Rights)] 抗胃潰瘍薬経口投与による脳・脊髄保護、神経機能再建・再生方法2005

    • Inventor(s)
      藤木 稔
    • Industrial Property Rights Holder
      藤木 稔
    • Industrial Property Number
      2005-165669
    • Filing Date
      2005-06-03
    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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