| Project/Area Number |
17591532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Showa University |
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Principal Investigator |
SUZUKI Ryuta Showa Univ., medical department, associate Prof, 医学部, 助教授 (10119216)
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| Co-Investigator(Kenkyū-buntansha) |
OKUDA Muneo Showa Univ., medical department, assistant, 医学部, 助手 (90384544)
SUZUKI Takao Showa Univ., medical department, assistant, 医学部, 研究補助員 (10459216)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | brain edema / Aquaporin / vascular endothelial growth factor / brain contusion / intracerebral hemorrhage / astrocyte |
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| Research Abstract |
Brain edema is an increase in brain volume due to an increased brain water content. It occurs secondary following various intracranial lesions. Brain edema results increased intracranial pressure, and causes the worst patients' prognosis. The causes of brain edema formations are an increased permeability of blood brain barrier and astrocytes. Mixed mechanisms of the vasogenic, ischemic, and neurotoxic type are contributing factors. Recent research has shown that astrocytes and aquaporins (AQPs), a large family of proteins that enables water to cross cell membranes, and vascular endothelial growth factor (VEGF) may play an important role in the formation and resolution of brain edema. In the present study, we evaluated the role of AQPs and astrocyte in edematous brain tissue. Also the progression and resolution of brain edema in some clinical situations.
Results : AQP1, AQP4, and VEGF were coexpressed in GFAP-positive astrocytes. AQP1 and AQP4 were strongly expressed in astrocytic end feet. The astrocytes were located in oedematous tissue and in cells surrounded by capillaries.
In the clinical study, we investigated edema progression in patients with putaminal hemorrhage. We found the edema progression is less severe in surgical treatment group than in conservative treatment group.
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