Establishment of the prophylaxis and treatment of the osteoporosis in rheumatoid arthritis
| Project/Area Number |
17591573
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tottori University |
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Principal Investigator |
TESHIMA Ryota Tottori University, Faculty of Medicine, Professor (50144671)
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| Co-Investigator(Kenkyū-buntansha) |
OKANO Toru Tottori University, Faculty of Medicine, Associate Professor (60252871)
ENOKIDA Makoto Tottori University, University Hospital, Assistant Professor (90372680)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | Rheumatoid arthritis / Osteoporosis / Prophylaxis / Treatment / Collagen-induced arthritis / Bone mineral density / Bisphosphonate / COX2 inhibitor / Rheumatoid arthritis / Osteoporosis / Prophylaxis / Treatment / Collagen-induced arthritis / Bone mineral density / COX2 inhibitor / Collagen induced arthritis / Bisphosphonate / Physical exercise |
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| Research Abstract |
The osteoporosis which combines in rheumatoid arthritis brings about bone fragility, lumbago and backache. Therefore, it is the serious complication which existing ADL failure is exacerbated. The effects of drug therapy for osteoporosis of the collagen-induced arthritis (CIA) rat which is animal model of RA, the relationship between knee joint deformity in human RA and osteoporosis, and influence of glucocorticoid (GC) on bone were investigated.
1. The inhibitory mechanism of bone resorption by minodronic acid, a nitrogen-containing bisphosphonate. in C1A rats was investigated. Minodronic acid inhibited the differentiation and the activation of osteoclasts not by inducing apoptosis but by inhibiting the RANKL-RANK, system, and thereby suppressing bone resorption.
2. The effects of COX2 inhibitor (celecoxib) on arthritis and bone mineral density in CIA rats was investigated. In the anti-inflammatory action, COX2 inhibitor was equivalent to the indomethacin, and being significantly stronge
… More
r than the indomethacin in bone resorption inhibitory effect.
3. The influence of estrogen therapy on changes in arthritis and bone mineral density was evaluated using an estrogen-replete CIA rat model. Estrogen could suppress arthritis and bone loss in estrogen-replete rats. This finding indicates the potential usefuleness of estrogen as an effective treatment for pre-menopausal RA patients as well as post-menopausal ones.
4. The relationship between knee deformity and osteoporosis in women with RA was examined. Knee deformity in RA was derived from deformity of the proximal tibia, and it was significantly correlated with age and bone mineral density in the lumbar spine and radius. Therefore, it is considered that preservation of the systemic bone mineral density is necessary for prevention of knee deformity in. RA.
5. The influence of GC on bone in rats at different age was investigated. Six-month-old rats treated with 20 mg/kg prednisolone showed dominant cancellous bone decrease and reduced bone turnover. Less
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Knee deformity in rheumatoid arthritis is closely correla ted with generalized osteoporosis2008
Author(s)
Kikkawa, T, Okano, T, Hagino, H, Otsuki, R, Katagiri, H, Teshima, R
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Journal Title
Modern Rheumatology 18
Pages: 45-51
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Minodronic acid influences receptor activator of nuclear factor K B-ligand expression and suppresses bone resorption by osteoclasts in rats with collagen-induced arthritis2007
Author(s)
Tanishima, S, Kishimoto, Y, Fukata, 8, Mizumura, H., Hagino, H, Teshima, R
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Journal Title
Modern Rheumatology 17
Pages: 198-205
Description
「研究成果報告書概要(欧文)」より
Related Report
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[Journal Article] Effect of COX-2 inhibitor(celecoxib)on bone mineral density in rats with collagen-induced arthritis2006
Author(s)
Aoki, T, Enokida, M., Nishihata, T., Shima, T, Hagino, H., Teshima, R
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Journal Title
The Journal of the Japanese Orthopaedic Association 80
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Influence of glucocorticoid on bone in three-, six, and twelve-month- old rats as determined by bone mass and histomorphometry
Author(s)
Ogoshi, T., Hagino, H, Fukata, S, Tanishima, S., Okano, T, Teshima, R
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Journal Title
Modern Rheumatology (in press)
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Effect of COX-2 inhibitor(Celecoxib)on bone mineral density in rats with collagen-induced arthritis2006
Author(s)
Aoki, T., Enokida, M, Nishihata, T, Shima, T., Hagino, H, Teshima, R
Organizer
The 21st Annual Research Meeting of the Japanese Orthopaedic Association
Place of Presentation
Nagasaki
Year and Date
2006-10-19
Description
「研究成果報告書概要(欧文)」より
Related Report
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