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Establishment of the prophylaxis and treatment of the osteoporosis in rheumatoid arthritis

Research Project

Project/Area Number 17591573
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionTottori University

Principal Investigator

TESHIMA Ryota  Tottori University, Faculty of Medicine, Professor (50144671)

Co-Investigator(Kenkyū-buntansha) OKANO Toru  Tottori University, Faculty of Medicine, Associate Professor (60252871)
ENOKIDA Makoto  Tottori University, University Hospital, Assistant Professor (90372680)
Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsRheumatoid arthritis / Osteoporosis / Prophylaxis / Treatment / Collagen-induced arthritis / Bone mineral density / Bisphosphonate / COX2 inhibitor / Rheumatoid arthritis / Osteoporosis / Prophylaxis / Treatment / Collagen-induced arthritis / Bone mineral density / COX2 inhibitor / Collagen induced arthritis / Bisphosphonate / Physical exercise
Research Abstract

The osteoporosis which combines in rheumatoid arthritis brings about bone fragility, lumbago and backache. Therefore, it is the serious complication which existing ADL failure is exacerbated. The effects of drug therapy for osteoporosis of the collagen-induced arthritis (CIA) rat which is animal model of RA, the relationship between knee joint deformity in human RA and osteoporosis, and influence of glucocorticoid (GC) on bone were investigated.
1. The inhibitory mechanism of bone resorption by minodronic acid, a nitrogen-containing bisphosphonate. in C1A rats was investigated. Minodronic acid inhibited the differentiation and the activation of osteoclasts not by inducing apoptosis but by inhibiting the RANKL-RANK, system, and thereby suppressing bone resorption.
2. The effects of COX2 inhibitor (celecoxib) on arthritis and bone mineral density in CIA rats was investigated. In the anti-inflammatory action, COX2 inhibitor was equivalent to the indomethacin, and being significantly stronge … More r than the indomethacin in bone resorption inhibitory effect.
3. The influence of estrogen therapy on changes in arthritis and bone mineral density was evaluated using an estrogen-replete CIA rat model. Estrogen could suppress arthritis and bone loss in estrogen-replete rats. This finding indicates the potential usefuleness of estrogen as an effective treatment for pre-menopausal RA patients as well as post-menopausal ones.
4. The relationship between knee deformity and osteoporosis in women with RA was examined. Knee deformity in RA was derived from deformity of the proximal tibia, and it was significantly correlated with age and bone mineral density in the lumbar spine and radius. Therefore, it is considered that preservation of the systemic bone mineral density is necessary for prevention of knee deformity in. RA.
5. The influence of GC on bone in rats at different age was investigated. Six-month-old rats treated with 20 mg/kg prednisolone showed dominant cancellous bone decrease and reduced bone turnover. Less

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (19 results)

All 2008 2007 2006 2005 Other

All Journal Article (14 results) (of which Peer Reviewed: 6 results) Presentation (5 results)

  • [Journal Article] Effect of estrogen replacement therapy on arthritis and bone mineral density in estrogen-replete rats with collagen-induced arthritis2008

    • Author(s)
      Yoshioka T
    • Journal Title

      Modern Rheumatology 18

      Pages: 23-28

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Knee deformity in rheumatoid arthritis is closely correlated with generalized osteoporosis2008

    • Author(s)
      Kikkawa T
    • Journal Title

      Modern Rheumatology 18

      Pages: 45-51

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of estrogen replacement therapy on arthritis and h one mineral density in estrogen-replete rats with collag en-induced arthritis2008

    • Author(s)
      Yoshioka, T., Hagino, H., Yamasaki, D, Okano, T, Teshima, R
    • Journal Title

      Modern Rheumatology 18

      Pages: 23-28

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Knee deformity in rheumatoid arthritis is closely correla ted with generalized osteoporosis2008

    • Author(s)
      Kikkawa, T, Okano, T, Hagino, H, Otsuki, R, Katagiri, H, Teshima, R
    • Journal Title

      Modern Rheumatology 18

      Pages: 45-51

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Minodronic acid influences receptor activator of nuclear factor κBligand expression and suppresses bone resorption by osteoclasts in rats with collagen-induced arthritis2007

    • Author(s)
      Tanishima S
    • Journal Title

      Modern Rheumatology 17

      Pages: 198-205

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Minodronic acid influences receptor activator of nuclear factor K B-ligand expression and suppresses bone resorption by osteoclasts in rats with collagen-induced arthritis2007

    • Author(s)
      Tanishima, S, Kishimoto, Y, Fukata, 8, Mizumura, H., Hagino, H, Teshima, R
    • Journal Title

      Modern Rheumatology 17

      Pages: 198-205

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] CIAラットの骨密度における選択的COA2阻害剤(セレコキシブ)の影響2006

    • Author(s)
      青木利暁
    • Journal Title

      日本整形外科学会雑誌 80

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Effect of COX-2 inhibitor(celecoxib)on bone mineral density in rats with collagen-induced arthritis2006

    • Author(s)
      Aoki, T, Enokida, M., Nishihata, T., Shima, T, Hagino, H., Teshima, R
    • Journal Title

      The Journal of the Japanese Orthopaedic Association 80

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] CIAラットの骨密度における選択的COX2阻害剤(セレコキシブ)の影響2006

    • Author(s)
      青木利暁
    • Journal Title

      日本整形外科学会雑誌 80・8

      Pages: 818-818

    • Related Report
      2006 Annual Research Report
  • [Journal Article] グルココルチコイド投与の骨に対する影響はらとの月齢で異なる2005

    • Author(s)
      生越智文
    • Journal Title

      日本整形外科学会雑誌 79

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] The influence of glucocorticoid on the bone is different depending the age of rat2005

    • Author(s)
      Ogoshi, T., Hagino, H, Okano, T., Teshima, R
    • Journal Title

      The Journal of the Japanese Orthopaedic Association 79

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Influence of glucocorticoid on bone in three-, six, and twelve-month-old rats as determined by bone mass and histomorphometry

    • Author(s)
      Ogoshi T
    • Journal Title

      Modern Rheumatology (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Influence of glucocorticoid on bone in three-, six, and twelve-month- old rats as determined by bone mass and histomorphometry

    • Author(s)
      Ogoshi, T., Hagino, H, Fukata, S, Tanishima, S., Okano, T, Teshima, R
    • Journal Title

      Modern Rheumatology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Bisphosphonates regulate receptor activator of nuclear factor κB ligand expression and suppress bone resorption by osteoclast in rats with collageninduced arthritis

    • Author(s)
      Tanishima S
    • Journal Title

      Modern Rheumatology (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] 成熟期コラーゲン関節炎ラットにおけるエストロゲン補充療法の効果2008

    • Author(s)
      吉岡 丈
    • Organizer
      第52回日本リウマチ学会総会
    • Place of Presentation
      札幌市
    • Year and Date
      2008-04-23
    • Related Report
      2007 Annual Research Report
  • [Presentation] CIAラットの骨密度における選択的COA2阻害剤(セレコキシブ)の影響2006

    • Author(s)
      青木利暁
    • Organizer
      日本整形外科学会
    • Place of Presentation
      長崎市
    • Year and Date
      2006-10-19
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Effect of COX-2 inhibitor(Celecoxib)on bone mineral density in rats with collagen-induced arthritis2006

    • Author(s)
      Aoki, T., Enokida, M, Nishihata, T, Shima, T., Hagino, H, Teshima, R
    • Organizer
      The 21st Annual Research Meeting of the Japanese Orthopaedic Association
    • Place of Presentation
      Nagasaki
    • Year and Date
      2006-10-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] グルココルチコイド投与の骨に対する影響はらとの月齢で異なる2005

    • Author(s)
      生越智文
    • Organizer
      日本整形外科学会
    • Place of Presentation
      三重県伊勢市
    • Year and Date
      2005-10-20
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] The influence of glucocorticoid on the bone is different depending the age of rat2005

    • Author(s)
      Ogoshi, T., Hagino, H, Okano, T., Teshima, R
    • Organizer
      The 20th Annual Research Meeting of the Japanese Orthopaedic Association
    • Place of Presentation
      Ise
    • Year and Date
      2005-10-20
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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