| Project/Area Number |
17591616
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Chiba University |
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Principal Investigator |
TANAKA Atsuko Chiba University, Graduate School of Medicine, Anesthesiology(B1), Assistant professor, 大学院医学研究院, 助手 (40302559)
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| Co-Investigator(Kenkyū-buntansha) |
ISONO Shiroh Chiba University, Graduate School of Medicine, Anesthesiology(B1), Associate Professor, 大学院医学研究院, 助教授 (80212968)
SEKINE Yasuo Chiba University, Graduate School of Medicine, Department of Throacic surgery, Assistant Professor, 大学院医学研究院, 講師 (70312957)
NISHINO Takashi Chiba University, Graduate School of Medicine, Anesthesiology(B1), Professor, 大学院医学研究院, 教授 (80009703)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 2005: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | COPD / respiration / swallowing / airway protection / upper airway reflex / dyspnea / lung volume / 呼吸困難 / 嚥下機能 / 気道防御反射 |
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| Research Abstract |
Incidence of postoperative respiratory complication is higher in patients with chronic obstructive lung disease (COPD) than non COPD patients. We hypothesized that impairment of airway protective reflexes in COPD patients may contribute to development of pulmonary aspiration.
Study 1 : In order to assess possible interaction between presence of dyspneic sensation and airway protective reflexes, we assessed performance of cough reflex and types and intensity of dyspneic sensation immediately after breakpoint of a breath-hold. We found 1) presence of dyspneic sensation did not impair voluntarily and citric acid-induced coughing, 2) air hunger sensation increased and prolonged during reflexically-induced coughing, 3) either voluntary or reflexically-induced coughing did not increase dyspneic sensation without preceding breath holding. These results suggest little contribution of dyspneic sensation to impairment of airway protective function in COPD patients, and more importantly occurrence
… More
of pulmonary aspiration is not predicted by intensity of dyspnea in COPD patients.
Study 2 : In order to assess swallowing function and mechanisms of its impairment, swallowing was induced by continuous infusion of distilled water into the pharynx in COPD patients. Unlike swallowing during resistive load in healthy subjects, number of swallows induced by the water infusion was not abnormally reduced. While swallows were predominantly induced during expiration and rarely induced during inspiration in healthy subjects, inspiratory or end-expiratory swallows were frequently observed in COPD patients. Considering incomplete swallows during inspiration or end expiration could aspirate materials in the pharynx into the trachea-bronchial trees, the swallowing pattern of COPD patients may increase chance of pulmonary' aspiration pneumonia.
In conclusion, swallowing patterns of COPD patients should be preoperatively assessed by continuous infusion of distilled water into the pharynx despite intensity of dyspneic sensation. Less
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