Basic mechanisms for age-dependent modification of actions of general anesthetics

• Project/Area Number: 17591620
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: University of Toyama
• Principal Investigator: KOKI Hirota University of Toyama, 大学院・医学薬学研究部(医学), 准教授 (30218854)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,760,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2005: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 全身麻酔薬 / 海馬 / シナプス伝達 / 加齢 / シナプス前終末 / GABA / シナナプス伝達 / 静脈麻酔薬 / 刺激頻度依存性 / 抑制性介在ニューロン

Research Abstract

ラット海馬スライス標本において, 静脈麻酔薬は抑制性介在ニューロンのシナプス前終末からのGABA放出を促進したが, この作用は加齢による修飾を受けた. 一方, 揮発性麻酔薬はGABA放出促進作用が弱く, 加齢による修飾も少なかった.

Research Products

• [Journal Article] The Pentax-AWS rigid indirect video laryngoscope : clinical assessment of performance in 320 cases (2008)
  • Author(s): Suzuki A, et.al.
  • Journal Title: Anaesthesia 63 Pages: 641-7
• [Journal Article] Perioperative anesthetic managements for the laryngo-tracheal separation and cadioplasy in a 17-year-old patient with Leigh syndrome (2008)
  • Author(s): Sasaki R, Nanjo K, Hirota K
  • Journal Title: Pediatric Anesthesia 18 Pages: 1133-4
• [Journal Article] Perioperative anesthetic managements for the laryngo-tracheal separation and cadioplasy in a 17-year-old patient with Leigh syndrome (2008)
  • Author(s): Sasaki R, et al.
  • Journal Title: Pediatric Anesthesia 18 Pages: 1133-4
  • Peer Reviewed
• [Journal Article] The Pentax-AWS rigid indirect video laryngoscope : clinical assessment of performance in 320 cases (2008)
  • Author(s): Suzuki A, et al.
  • Journal Title: Anaesthesia 63 Pages: 641-7
  • Peer Reviewed
• [Journal Article] 新しい気道確保道具エアウェイスコープの有用性 (2007)
  • Author(s): 鈴木昭広, 他
  • Journal Title: 麻酔 56 Pages: 464-8
• [Journal Article] 症例検討「Awake craniotomyと麻酔管理」 : あらゆる危機的状況に対応できるskill (2006)
  • Author(s): 廣田弘毅, 山崎光章, 栗本昌紀
  • Journal Title: 手術室の司令塔としての資質が試される.Lisa 13 Pages: 678-81
• [Journal Article] 海馬シナプス伝達に及ぼす全身麻酔薬の作用 (2006)
  • Author(s): 廣田弘毅
  • Journal Title: 麻酔 55 Pages: 145-52
• [Journal Article] The intravenous anesthetics have more effect on the inhibitory pathways than volatile anesthetics in rat hippocampal CA1 (2006)
  • Author(s): Asahi T, Hirota K, Sasaki R, Roth SH, et.al.
  • Journal Title: Anesth Analg 102 Pages: 772-8
• [Journal Article] The intravenous anesthetics have more effect on the inhibitory pathways than volatile anesthetics in rat hippocampal CA1 (2006)
  • Author(s): Asahi T, Hirota K, et al.
  • Journal Title: Aneshesia ＆ Analgesia 102 Pages: 772-778
• [Journal Article] 揮発性麻酔薬,静脈麻酔薬はどこに作用するか (2006)
  • Author(s): 廣田 弘毅
  • Journal Title: 麻酔科診療プラクティス 20 Pages: 10-16
• [Journal Article] 海馬シナプス伝達に及ぼす全身麻酔薬の作用 (2006)
  • Author(s): 廣田 弘毅
  • Journal Title: 麻酔 55
• [Journal Article] Anoxic depolarization of rat hippocampal slices is prevented by thiopental but not by propofol or isoflurane (2005)
  • Author(s): Sasaki R, Hirota K, Roth SH, et.al.
  • Journal Title: Br J Aaesth 94 Pages: 486-91
• [Journal Article] Anoxic depolarization of rat hippocampal slices is prevented by thiopental but not by porpofol or isoflurane (2005)
  • Author(s): Sasaki R, Hirota K, et al.
  • Journal Title: British Journal of Anaesthesia 94 Pages: 486-491
• [Presentation] ラット海馬CA1領域の抑制性介在ニューロンに及ぼす全身麻酔薬の作用 (2008)
  • Author(s): 廣田弘毅, 佐々木利佳, 武部真理子, 他
  • Organizer: 第25回麻酔メカニズム研究会
  • Place of Presentation: 大阪
• [Presentation] Age-related modification on the effects of intravenous anesthetic in rat hippocampal CA1 (2008)
  • Author(s): Sasaki R, Hirota K, Yamazaki M
  • Organizer: 6th Forum of European Neuroscience
  • Place of Presentation: Geneva, Switherland
• [Presentation] Effects of general anesthetics on presynaptic functions of inhibitory interneurons in the rat hippocampal CA1 (2008)
  • Author(s): Hiroa K, Sasaki R, Yamazaki M
  • Organizer: 6th Forum of European Neuroscience
  • Place of Presentation: Geneva, Switherland
• [Presentation] 加齢による麻酔薬作用修飾メカニズムの検討第3報(優秀演題) (2008)
  • Author(s): 佐々木利佳, 廣田弘毅, 山崎光章
  • Organizer: 第55回日本麻酔科学会
  • Place of Presentation: 横浜
• [Presentation] Effects of general anesthetics on presynaptic functions of inhibitory intemeurons in the rat hippocampal CA1 (2008)
  • Author(s): Hirota K, et al.
  • Organizer: 6th European Neuroscience
  • Place of Presentation: Geneva, Switherland
• [Presentation] 海馬シナプス伝達に及ぼす静脈麻酔薬・揮発性麻酔薬の作用 (2006)
  • Author(s): 廣田弘毅, 佐々木利佳, 朝日丈尚, 他
  • Organizer: 第23回麻酔メカニズム研究会
  • Place of Presentation: 大阪
• [Presentation] Age-related modification of the effects of general anesthetics in rat hippocampal CA1 (2006)
  • Author(s): Sasaki R, Hirota K, Asahi T, et.al.
  • Organizer: 5th Forum of European Neuroscience
  • Place of Presentation: Vienna, Austria
• [Presentation] General anesthetics produce stimulus-dependent modification of synaptic transmission in the rat hippocampal CA1 in vitro (2006)
  • Author(s): Hirota K, Sasaki R, Asahi T, et.al.
  • Organizer: 5th Forum of European Neuroscience
  • Place of Presentation: Vienna, Austria
• [Presentation] 加齢による麻酔作用修飾メカニズムの検討 (2006)
  • Author(s): 佐々木利佳, 廣田弘毅, 朝日丈尚, 他
  • Organizer: 第53回日本麻酔科学会
  • Place of Presentation: 神戸
• [Presentation] 海馬シナプス伝達に及ぼす全身麻酔薬の作用. シンポジウム「麻酔の本態を探る」 (2006)
  • Author(s): 廣田弘毅
  • Organizer: 第53回日本麻酔科学会
  • Place of Presentation: 神戸
• [Presentation] 麻酔導入後偶発的に伝導障害を発症した4症例 : 手術延期するか否か (2005)
  • Author(s): 佐々木利佳, 廣田弘毅, 村花準一, 他
  • Organizer: 第25回臨床麻酔学会
  • Place of Presentation: 大阪
• [Presentation] 糖尿病患者における術中輸液の検討 (2005)
  • Author(s): 佐々木利佳, 廣田弘毅, 山崎光章
  • Organizer: 第95回日本麻酔科学会東海・北陸支部東海地方会
  • Place of Presentation: 名古屋
• [Presentation] Differential actions of volatile and intravenous anesthetics on recurrent inhibitory interneurons in rat hippocampal slices (2005)
  • Author(s): Asahi T, Hirota K, Sasaki R, et.al.
  • Organizer: 7th International Conference on Basic and Systemic Mechanisms of Anesthesia
  • Place of Presentation: Nara, Japan
• [Presentation] Thiopental prevents anoxic depolarization during anoxia in area CA1 of rat hippocampal slices (2005)
  • Author(s): Sasaki R, Hirota K, Asahi T, et.al.
  • Organizer: 7th International Conference on Basic and Systemic Mechanisms of Anesthesia
  • Place of Presentation: Nara, Japan
• [Presentation] Effects of general anesthetics on excitatory and inhibitory synaptic pathways of hippocampus in vitro. Workshop: Will neural networks provide the answer to anesthetic mechanisms of action? (2005)
  • Author(s): Hirota K
  • Organizer: 7th International Conference on Basic and Systemic Mechanisms of Anesthesia
  • Place of Presentation: Nara, Japan
• [Book] 副腎・甲状腺機能障害. The ICU Book 3rd ed. (William & Wilkins) (2008)
  • Author(s): 佐々木利佳, 廣田弘毅
  • Publisher: 稲田英一監訳. メディカル・サイエンス・インターナショナル(東京)
• [Book] 栄養素と必要カロリー. The ICU Book 3rd ed. (William & Wilkins) (2008)
  • Author(s): 廣田弘毅, 佐々木利佳
  • Publisher: 稲田英一監訳. メディカル・サイエンス・インターナショナル(東京)
• [Book] ICUブック(第3版) (2008)
  • Author(s): 廣田弘毅, 他
  • Total Pages: 894
  • Publisher: メディカル・サイエンス・インターナショナル(東京)
• [Book] 自律神経系 : 薬理学.Miller's Anesthesia, 6th edition, Ronald D. Miller(編) (2007)
  • Author(s): 廣田弘毅
  • Publisher: 武田純三監修. メディカル・サイエンス・インターナショナル(東京)
• [Book] 揮発性麻酔薬, 静脈麻酔薬はどこに作用するか. 麻酔科診療プラクティス20. 高崎眞弓, 弓削孟文, 稲田英一, 岩崎寛(編) (2006)
  • Author(s): 廣田弘毅
  • Publisher: 武田純三監修. メディカル・サイエンス・インターナショナル(東京)
• [Book] Differential actions of volatile and intravenous anesthetics on recurrent inhibitory interneurons in rat hippocampal slices. Basic and Systemic Mechanisms of Anesthesia. T. Mashimo, K. Ogli, I Uchida(eds.)International Congress Series 1283 (2005)
  • Author(s): Asahi T, Hirota K, Sasaki R, et.al.
  • Publisher: Elsevier, Amsterdam, The Netherlands
• [Book] Thiopental prevents anoxic depolarization during anoxia in area CA1 of rat hippocampal slices. Basic and Systemic Mechanisms of Anesthesia. T. Mashimo, K. Ogli, I Uchida(eds.)International Congress Series 1283 (2005)
  • Author(s): Sasaki R, Hirota K, Asahi T, et.al.
  • Publisher: Elsevier, Amsterdam, The Netherlands
• [Book] Effects fo general anesthetics on excitatory and inhibitory synaptic pathways of hippocampus in vitro. Basic and Systemic Mechanisms of Anesthesia. T. Mashimo, K. Ogli, I Uchida(eds.)International Congress Series 1283 (2005)
  • Author(s): Hirota K, Sasaki R, Asahi T, et.al.
  • Publisher: Elsevier, Amsterdam, The Netherlands
• [Book] 全身麻酔とマグネシウム.マグネシウムの基礎と臨床. 外須美夫(編集) (2005)
  • Author(s): 廣田弘毅, 佐々木利佳
  • Publisher: 真興交易医書出版, 東京
• [Book] マグネシウムの基礎と臨床 (2005)
  • Author(s): 廣田 弘毅, 佐々木 利佳
  • Total Pages: 174
  • Publisher: 真興交易医書出版,東京
• [Remarks]
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• [Remarks]
  • URL: http://web.mac.com/morpheus_sq/iWeb/Koki/Welcome.html