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Investigation of the role of the fibrinolytic system in cardiac remodeling and its clinical relevance

Research Project

Project/Area Number 17591623
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionGifu University

Principal Investigator

AKAMATSU Shigeru  Gifu University, graduate School of Medicine, Part time lecturer, 大学院医学系研究科, 非常勤講師 (20167828)

Co-Investigator(Kenkyū-buntansha) KOZAWA Osamu  Gifu University, graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (90225417)
DOHI Shuji  Gifu University, graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (40155627)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywordscardiac myocytes / ischemia / heat shock protein / crstallin / molecular chaperone / 血小板 / 血栓 / 凝固・線溶系
Research Abstract

We investigated the role of the fibrinolytic system in cardiac remodeling and its clinical relevance. αB-crystallin is the most abundant low-molecular-weight heat shock protein in heart and recent studies have demonstrated that it plays a cardioprotective role during myocardial infarction both in vivo and in vitro. On the other hand, platelet-derived growth factor (PDGF), a potent serum mitogen, has been reported to improve cardiac function after myocardial infarction. Using a mouse myocardial infarction model, we investigated whether αB-crystallin is phosphorylated during myocardial infarction and the implication of PDGF-BB. Phosphorylation of αB-crystallin at Ser-59 was time dependently induced and plasma PDGF-BB levels were concomitantly increased. Moreover, PDGF-BB-stimulated phosphorylation of αB-crystallin was suppressed by SB203580, a specific inhibitor of p38 mitogen-activated protein kinase, in primary cultured cardiac myocytes.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (5 results)

All 2005

All Journal Article (5 results)

  • [Journal Article] Midazolam suppresses thrombin-induced heat shock protein 27 phosphorylation through inhibition of p38 mitogen-activated protein kinase in cardiac myocytes.2005

    • Author(s)
      Tanabe K, Akamatsu S, Suga H, Takai S, Kato K, Dohi S, Kozawa O
    • Journal Title

      J. Cell. Biochem. 96

      Pages: 56-64

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells.2005

    • Author(s)
      Suga H, Nakajima K, Shu E, Kanno Y, Hirade K, Ishisaki A, Matsuno H, Tanabe K, Akamatsu S, Kato K, Oiso Y, Kozawa O
    • Journal Title

      Arch. Biochem. Biophys 438

      Pages: 137-145

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] αB-crystallin is phosphorylated during myocardial infarction : involvement of platelet-derived growth factor-BB.2005

    • Author(s)
      Shu E, Matsuno H, Akamatsu S, Kanno Y, Suga H, Nakajima K, Ishisaki A, Kato K, Kitajima Y, Kozawa O
    • Journal Title

      Arch. Biochem. Biophys. 438

      Pages: 111-118

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells.2005

    • Author(s)
      Suga H, Nakajima K, Shu E, Kanno Y, Hirade K, Ishisaki A, Matsuno H, Tanabe K, Akamatsu S, Kato K, Oiso Y, Kozawa O
    • Journal Title

      Arch. Biochem. Biophys. 438

      Pages: 137-145

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] αB-crystallin is phosphorylated during myocardial infarction : involvement of platelet-derived growth factor-BB.2005

    • Author(s)
      Shu E, Matsuno H, Akamatsu S, Kanno Y, Suga H, Nakajima K, Ishisaki A, Kato K, Kitajima Y, Kozawa O
    • Journal Title

      Arch.Biochem.Biophys. 438

      Pages: 111-118

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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