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Involvements of ion channels and delayed gene in the relation between respiration and pain

Research Project

Project/Area Number 17591624
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionJapanese Foundation For Cancer Research (2007)
Teikyo University (2005-2006)

Principal Investigator

TSUTOMU Oshima  Japanese Foundation For Cancer Research, Department of Anesthesiology, vice director (50223805)

Project Period (FY) 2005 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordscontrol of respiration / pain / nociception / anesthesia / リズム運動 / セロトニン / 呼吸
Research Abstract

My scientific research project 'Involvements of ion channels and delayed gene in the relation between respiration and pain' is has resulted in five original articles and nineteen research presentations in scientific congress from pole to pole. I believe that in the near future many original articles will be published among these research presentations. The promising research I recommend with the strongest confidence among these various projects is clarification of mechanisms of exercise-induced analgesia In 2007 ASA Annual Meeting, our research presentation titled 'Pedaling exercise-induced analgesia is achieved via serotonergic descending inhibitory pathway' was admired by the audience.

Report

(4 results)
  • 2007 Annual Research Report   Final Research Report Summary
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (51 results)

All 2008 2007 2006 2005

All Journal Article (19 results) (of which Peer Reviewed: 6 results) Presentation (30 results) Book (2 results)

  • [Journal Article] Recovery of neuromuscular blockade caused by vecuronium is delayed in patients with hypertriglyceridemia2008

    • Author(s)
      Saitoh Y
    • Journal Title

      J Anesth 22

      Pages: 89-92

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Recovery of neuromuscular blockade caused by vecuronium is delayed in patients with hypertriglyceridemia.2008

    • Author(s)
      Saitoh Y.
    • Journal Title

      J Anesth 22

      Pages: 89-92

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Recovery of neuromuscular blockade caused by vecuronium is delayedin patients with hypertriglyceridemia2008

    • Author(s)
      Yuhji Saitoh
    • Journal Title

      Journal of Anesthesia 22

      Pages: 89-92

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of independent predictors of thiopental-induced yawning2007

    • Author(s)
      Oshima T
    • Journal Title

      J Anesth 21

      Pages: 131-135

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 麻酔とあくび2007

    • Author(s)
      大島 勉
    • Journal Title

      臨床麻酔 31

      Pages: 861-868

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Journal Article] Identification of independent predictors of thiopental-induced yawning.2007

    • Author(s)
      Oshima T.
    • Journal Title

      J Anesth 21

      Pages: 131-135

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of independent predictors for intravenous thiopental-induced yawning2007

    • Author(s)
      Tsutomu Oshima
    • Journal Title

      Journal of Anesthesia 21

      Pages: 131-135

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ペルー麻酔学会に参加して2006

    • Author(s)
      大島 勉
    • Journal Title

      臨床麻酔 30

      Pages: 121-122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of independent risk factors of fentanyl-induced cough2006

    • Author(s)
      Oshima T
    • Journal Title

      Can J Anesth 53

      Pages: 753-758

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] Identification of independent risk factors of fentanyl-induced cough2006

    • Author(s)
      Oshima T.
    • Journal Title

      Can J Anesth 53

      Pages: 753-758

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Anesthesia and yawning.2006

    • Author(s)
      Oshima T.
    • Journal Title

      Jap J Clin Anesthesia 30

      Pages: 121-122

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Identification of independent risk factors of fentanyl-induced cough2006

    • Author(s)
      Oshima T, et al.
    • Journal Title

      Canadian Journal of Anesthesia 53/8

      Pages: 753-8

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ペルー麻酔学に参加して2006

    • Author(s)
      大島 勉
    • Journal Title

      臨床麻酔 30・1

      Pages: 121-122

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Does yawning represent a transient arousal-shift during intravenous induction of general anesthesia?2005

    • Author(s)
      Kasuya Y
    • Journal Title

      Anesth Analg 101

      Pages: 382-384

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
    • Peer Reviewed
  • [Journal Article] 塩酸ニカルジピンはチオペンタール誘発性あくび反応を抑制する2005

    • Author(s)
      大島 勉
    • Journal Title

      Therapeutic Res 26

      Pages: 6-8

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Does yawning represent a transient arousal-shift during intravenous induction of general anesthesia-2005

    • Author(s)
      Kasuya Y.
    • Journal Title

      Anesth Analg 101

      Pages: 382-384

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Nicardipine suppresses thiopental-induced yawning in humans.2005

    • Author(s)
      Oshima T.
    • Journal Title

      Therapeutic Res 26

      Pages: 6-8

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Journal Article] Does yawning represent a transient arousal-shift during intravenous induction of general anesthesia?2005

    • Author(s)
      Kasuya Y, Murakami T, Oshima T, et al.
    • Journal Title

      Anesthesia & Analgesia 101・2

      Pages: 382-384

    • Related Report
      2005 Annual Research Report
  • [Journal Article] 塩酸ニカルジピンはチオペンタール誘発性あくび反応を抑制する2005

    • Author(s)
      大島 勉, 粕谷由子, 村上辰男 他
    • Journal Title

      Therapeutic Research 26・R8

      Pages: 6-8

    • Related Report
      2005 Annual Research Report
  • [Presentation] Systemic blockade of 5-hydroxytryptaminelA receptors increases sevoflurane minimum alveolar concentration in rats2008

    • Author(s)
      Oshima T
    • Organizer
      14th World Congress of Anaesthesiologists
    • Place of Presentation
      Cape Town,South Africa
    • Year and Date
      2008-03-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Systemic blockade of 5-hydroxytryptaminel A receptors increases sevoflurane minimum alveolar concentration in rats2008

    • Author(s)
      Oshima T.
    • Organizer
      14th World Congress of Anaesthesiologists
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2008-03-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] 自転車こぎ運動はセロトニン神経による下行性痛覚抑制系を賦活化する2007

    • Author(s)
      麓 正樹
    • Organizer
      第35回自律神経研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Cycling exercise produces activation of prefrontal cortex and augmentation of high-frequency alpha band in EEG:Role of brain serotonergic system2007

    • Author(s)
      Fumoto M
    • Organizer
      Neuroscience 2007
    • Place of Presentation
      San Diego,USA
    • Year and Date
      2007-11-06
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Cycling exercise produces activation of prefrontal cortex and augmentation of high-freuency alpha band in EEG : Role of brain serotonergic system.2007

    • Author(s)
      Fumoto M.
    • Organizer
      Neuroscience 2007.
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Systemic blockade of orexin-l receptors decreases sevoflurane minimum alveolar concentration in rats2007

    • Author(s)
      Oshima T
    • Organizer
      2007 American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-10-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Systemic blockade of orexin-1 receptors decreases sevoflurane minimum alveolar concentration in rats2007

    • Author(s)
      Oshima T.
    • Organizer
      2007 American Society of Anesthesiologists Annual Meeting
    • Year and Date
      2007-10-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Systemic blockade of orexin-1 receptors decreases sevoflurane minimum alveolar concentration m rats2007

    • Author(s)
      Oshima T
    • Organizer
      2007 American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-10-17
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pedaling exercise-induced analgesia is achieved via serotonergic descending inhibitory pathway2007

    • Author(s)
      Oshima T
    • Organizer
      2007 American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-10-16
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] Pedaling exercise-induced analgesia is achieved via serotonergic descending inhibitory pathway2007

    • Author(s)
      Oshima T.
    • Organizer
      2007 American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-10-16
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Sevoflurane inhalation reduces tracheal intubation induced activation of salivary α-amylase activity2007

    • Author(s)
      Nakada T
    • Organizer
      2007 American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      San Francisco,USA
    • Year and Date
      2007-10-14
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] 分離肺換気中の患者では、ベクロニウム投与後の筋力の回復が早い2007

    • Author(s)
      斎藤祐司
    • Organizer
      日本麻酔科学会第54回大会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ラットで全身のセロトニン_<2A,2B,2C>受容体を拮抗するとセボフルランの最小肺胞濃度は減少する2007

    • Author(s)
      大島 勉
    • Organizer
      日本麻酔科学会第54回大会
    • Place of Presentation
      札幌
    • Year and Date
      2007-05-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラットで全身のセロトニン1A受容体を拮抗するとセボフルランの最小肺胞濃度は増加する2007

    • Author(s)
      浦野晃義
    • Organizer
      日本麻酔科学会第54回大会
    • Place of Presentation
      札幌
    • Year and Date
      2007-05-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Annual Research Report 2007 Final Research Report Summary
  • [Presentation] ラットで全身のglycine、GABAA、GABAB受容体を拮抗するとセボフルランの最小肺胞濃度は増加する2007

    • Author(s)
      長谷洋和
    • Organizer
      日本麻酔科学会第54回大会
    • Place of Presentation
      札幌
    • Year and Date
      2007-05-31
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ラットで全身のセロトニン_<2A,2B,2C>受容体を拮抗するとセポフルランの最小肺胞濃度は減少する2007

    • Author(s)
      大島 勉
    • Organizer
      日本麻酔科学会第54回大会
    • Place of Presentation
      札幌
    • Year and Date
      2007-05-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラットで全身のグリシン、GABAA、GABAB受容体を拮抗するとセボフルランの最小肺胞濃度は上昇する2007

    • Author(s)
      長谷 洋和
    • Organizer
      日本麻酔科学会第54回大会
    • Place of Presentation
      札幌
    • Year and Date
      2007-05-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] Systemic blockade of 5-hydroxytryptamine_<2A,2B,2C> receptors decreases sevoflurane minimum alveolar concentration in rats2007

    • Author(s)
      Urano A
    • Organizer
      IARS 81st Clinical and Scientific Congress
    • Place of Presentation
      Orlando,USA
    • Year and Date
      2007-03-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Systemic blockade of glycine,gamma aminobutyric acid(GABA)_A,and GABA_B receptors increases sevoflurane minimum alveolar concentration in rats2007

    • Author(s)
      Nagatani H
    • Organizer
      IARS 81st Clinical and Scientific Congress
    • Place of Presentation
      Orlando,USA
    • Year and Date
      2007-03-24
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ペダリング運動が脳波と局所脳血流に及ぼす影響:セロトニン神経系の役割2007

    • Author(s)
      麓 正樹
    • Organizer
      第84回日本生理学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-03-21
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of independent predictors of thiopental-induced yawning2006

    • Author(s)
      Oshima T
    • Organizer
      2006 American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      Chicago,USA
    • Year and Date
      2006-10-17
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Identification of independent predictors of thiopental-induced yawning2006

    • Author(s)
      Oshima T.
    • Organizer
      2006 American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2006-10-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Hiccup?Hoquet?Hipo?-Clinical physiology of hiccups-2005

    • Author(s)
      Oshima T
    • Organizer
      I Congreso Internacional de Especialidades en Anestesia,Analgesia y Reanimacion
    • Place of Presentation
      Lima,Peru
    • Year and Date
      2005-11-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Hiccup?Hoquet?Hipo?-A phylogenetic hypothesis for the origin of hiccough-2005

    • Author(s)
      Oshima T
    • Organizer
      I Congreso Internacional de Especialidades en Anestesia,Analgesia y Reanimacion
    • Place of Presentation
      Lima,Peru
    • Year and Date
      2005-11-01
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Hiccup? Hoquet? Hipo? -Clinical physiology of hiccups-2005

    • Author(s)
      Oshima T.
    • Organizer
      I Congreso Internacional de Especialidades en Anestesia, Analgesia y Reanimacion.
    • Place of Presentation
      Lima, Peru
    • Year and Date
      2005-11-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Hiccup? Hoquet? Hipo? -A phylogenetic hypothesis for the origin of hiccough-2005

    • Author(s)
      Oshima T.
    • Organizer
      I Congreso Internacional de Especialidades en Anestesia, Analgesia y Reanimacion.
    • Place of Presentation
      Lima, Peru
    • Year and Date
      2005-11-01
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Inhibitory effects of nicardipine and landiolol on thiopental-induced yawning in a dults2005

    • Author(s)
      Murakami T
    • Organizer
      2005 American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      Atlanta,USA
    • Year and Date
      2005-10-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Opposing gamma-aminobutyric acidergic modulation of baclofen-induced suppression in hiccup-like reflex in pentobarbital-anesthetized cats2005

    • Author(s)
      Oshima T
    • Organizer
      2005 American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      Atlanta,USA
    • Year and Date
      2005-10-25
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] Opposing gamma-aminobutyric acidergic modulation of baclofen-induced suppression in hiccup-like reflex in pentobarbital-anesthetized cats.2005

    • Author(s)
      Oshima T.
    • Organizer
      2005 American Society of Anesthesiologists Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2005-10-25
    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Presentation] ニカルジピンはチオペンタール誘発性欠伸反応を抑制する2005

    • Author(s)
      村上辰男
    • Organizer
      日本麻酔科学会第52回大会
    • Place of Presentation
      神戸
    • Year and Date
      2005-06-04
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 麻酔科診療プラクテイス20 臨床麻酔の疑問に答える生理学2006

    • Author(s)
      大島 勉
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2007 Final Research Report Summary
  • [Book] 麻酔科診療プラクテイス202006

    • Author(s)
      大島 勉ほか
    • Total Pages
      258
    • Publisher
      文光堂
    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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