| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2005: ¥2,800,000 (Direct Cost: ¥2,800,000)
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| Research Abstract |
1)Prolonged recovery after ambulatory surgery is mainly due to postoperative unpleasant symptoms (pain, postoperative nausea and vomiting (PONV), drowsiness/dizziness/fatigue) and secondly due to social/system problems. Delayed patients complained postoperative pain more frequently, and reported lower self-rated resumption of normal activity (RNA) levels and acceptability for ambulatory surgery. Patients in lower satisfaction levels reported postoperative unpleasant symptoms more frequently, and lower RNA level and acceptability. Twenty percent of patients had moderate to severe pain after ambulatory surgery. In short-stay breast cancer surgery, sevoflurane anesthesia combined with fentanyl revealed higher PONV rate and delayed postoperative recovery ; total intravenous anesthesia (TIVA) revealed lower intraoperative hemodynamic changes and inhibition in heart rate variability (HRV), lower PONV rate, and faster postoperative recovery than sevoflurane anesthesia; sevoflurane anesthesia
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combined with dexmedetomidine revealed intraoperative hypotension and bradycardia episodes more frequently, and delayed recovery without affecting severity in postoperative pain and PONV ; sevoflurane "light" anesthesia revealed faster emergence without affecting PONV frequency and HRV inhibition.
2)The automated closed-loop control system for propofol infusion using bispectral index (BIS) value as a controlled variable was developed. In TIVA, it maintained the BIS value more precisely than manual control. However, in monitored anesthesia care, control was difficult.
3)In cultured rat tracheal epithelial cells, thiopental, midazolam and dexmedetomidine did not affect ciliary motility, but high doses of ketamine and fentanyl augmented it and pentbarbital depressed it strongly. Halothane and isoflurane decreased it vigorously, but seveflurane did minimally. Isoflurane inhibited isoproterenol-induced cilio-stimulation, but did not depress increased intracellular cAMP levels. Isoflurane did not affect intracellular ATP levels. Less
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