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Long-term evaluation of gray and white matter injury in models of spinal cord ischemia.

Research Project

Project/Area Number 17591649
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNara Medical University

Principal Investigator

KAWAGUCHI Masahiko  Nara Medical University, 医学部, 准教授 (60275328)

Co-Investigator(Kenkyū-buntansha) INOUE Satoki  奈良県立医科大学, 医学部, 講師 (50295789)
SASAOKA Noriyuki  奈良県立医科大学, 医学部, 助教 (70364073)
FURUYA Hitoshi  奈良県立医科大学, 医学部, 教授 (70183598)
加藤 晴登  奈良県立医科大学, 医学部, 助手 (30382295)
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
Keywords脊髄虚血 / 白質 / 灰白質 / 神経細胞死 / ラット / 低体温 / ウサギ
Research Abstract

脊髄虚血モデルを用い、軽度低体温や各種薬剤の脊髄虚血後の灰白質傷害と白質傷害への影響について検討した。脊髄虚血後の灰白質傷害と白質傷害はその発症様式や時間的経過が異なることが明らかになり、各種の治療的手段の効果についても異なることが明らかになった。また、灰白質傷害と白質傷害の回復過程の変化を明らかにすることで、機能回復のための治療戦略の可能性を示唆した。

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (18 results)

All 2009 2008 2007 2006 2005 2004

All Journal Article (8 results) (of which Peer Reviewed: 3 results) Presentation (10 results)

  • [Journal Article] Long-term effects of mild hypothermia on gray and white matter injury after spinal cord ischemia in rats2009

    • Author(s)
      Horiuchi T, Kawaguchi M, et al.
    • Journal Title

      Anesthesia and Analgesia (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats2008

    • Author(s)
      Horiuchi T, Kawaguchi M, Kurita N, Sakamoto T, Nakamura M, Konishi N, Furuya H
    • Journal Title

      J Anesth 22

      Pages: 32-37

    • NAID

      10024128545

    • Related Report
      2008 Final Research Report
  • [Journal Article] Effects of delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats2008

    • Author(s)
      Horiuchi T, Kawaguchi M, et al.
    • Journal Title

      Journal of Anesthesia 22

      Pages: 32-37

    • NAID

      10024128545

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of delta-opioid agonist SNC80 on white matter injury following spinal cord ischemia in normothermic and mildly hypothermic rats2008

    • Author(s)
      Horiuchi T, Kawaguchi M, et. al.
    • Journal Title

      Journal of Anesthesia 22

      Pages: 32-37

    • NAID

      10024128545

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reevaluation of gray and white matter injury after spinal cord ischemia in rabbits2006

    • Author(s)
      Kurita N, Kawaguchi M, Kakimoto M, Yamamoto Y, Inoue S, Nakamura M, Konishi N, Patel PM, Furuya H
    • Journal Title

      Anesthesiology 105

      Pages: 305-312

    • Related Report
      2008 Final Research Report
  • [Journal Article] Reevaluation of gray and white matter injury after spinal cord ischemia in rabbits.2006

    • Author(s)
      Kurita N, Kawaguchi M, Kakimoto M, et al.
    • Journal Title

      Anesthesiology 105(2)

      Pages: 305-312

    • Related Report
      2006 Annual Research Report
  • [Journal Article] An evaluation of white matter injury after spinal cord ischemia in rats : A comparison with gray matter injury2005

    • Author(s)
      Kurita N, Kawaguchi M, Horiuchi T, Inoue S, Sakamoto T, Nakamura M, Konishi N, Furuya H
    • Journal Title

      Anesth Analg 100

      Pages: 847-854

    • Related Report
      2008 Final Research Report
  • [Journal Article] An evaluation of white matter injury after spinal cord ischemia in rats2005

    • Author(s)
      Kurita N, Kawaguchi M, Horiuchi T, et al.
    • Journal Title

      Anesth Analg 100(3)

      Pages: 847-854

    • Related Report
      2005 Annual Research Report
  • [Presentation] ミノサイクリンのラット脊髄虚血後の神経傷害に及ぼす影響2009

    • Author(s)
      竹田政史, 川口昌彦, 他
    • Organizer
      日本麻酔科学会 第56回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] ミノサイクリンがラット脊髄虚血後の後肢運動機能および神経細胞傷害に及ぼす影響2009

    • Author(s)
      竹田政史、熊取谷知征、川口昌彦、堀内俊孝、古家仁
    • Organizer
      日本麻酔科学会 第56回学術集会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] 家兎脊髄虚血モデルにおけるキセノンの脊髄保護効果の検討 : プロポフォールとの比較2008

    • Author(s)
      山本百合, 川口昌彦, 他
    • Organizer
      日本臨床麻酔学会第28回大会
    • Place of Presentation
      京都
    • Year and Date
      2008-11-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] ラット脊髄虚血後の灰白質及び白質傷害に対する軽度低体温の長期的効果の検討2007

    • Author(s)
      堀内 俊孝、川口 昌彦, 他
    • Organizer
      日本麻酔科学会 第54回学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2007-06-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] ラット脊髄虚血後の灰白質及び白質傷害に対する軽度低体温の長期的効果の検討2007

    • Author(s)
      堀内俊孝、川口昌彦、栗田直子、井上聡己、古家仁
    • Organizer
      日本麻酔科学会第54回学術集会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] Long Term Assessment of White Matter Injury after Spinal Cord Ischemia in Rabbits2005

    • Author(s)
      Kurita N、Kawaguchi M, Kakimoto M, Inoue S, Furuya H
    • Organizer
      Long Term Assessment of White Matter Injury after Spinal Cord Ischemia in Rabbits. American Society of Anesthesiologists
    • Place of Presentation
      Atlanta
    • Related Report
      2008 Final Research Report
  • [Presentation] 家兎脊髄虚血モデルにおける白質傷害の長期的検討2005

    • Author(s)
      栗田直子, 川口昌彦、垣本めいこ、山本百合、井上聡己、古家仁
    • Organizer
      第52回日本麻酔科学会総会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] 脳脊髄虚血後の白質傷害2005

    • Author(s)
      川口昌彦、古家仁
    • Organizer
      第9回日本神経麻酔集中治療研究会
    • Place of Presentation
      長崎
    • Related Report
      2008 Final Research Report
  • [Presentation] δ-opioid agonist SNC80は軽度低体温の脊髄保護効果を増強するか?2005

    • Author(s)
      堀内俊孝、川口昌彦、井上聡己、栗田直子、坂本尚典、中村光利、小西登、古家仁
    • Organizer
      第9回日本神経麻酔集中治療研究会
    • Place of Presentation
      長崎
    • Related Report
      2008 Final Research Report
  • [Presentation] Evaluation of white matter injury after spinal cord ischemia in rats. A comparison with gray matter injury and hind-limb motor function2004

    • Author(s)
      Kurita N, Kawaguchi M, Horiuchi T, Inoue S, Furuya H
    • Organizer
      American Society of Anesthesiologists, 2004 annual meeting, Las Vegas 2004
    • Related Report
      2008 Final Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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