Effects of New Photodynamic Therapy to Testicular Tumor Cells

• Project/Area Number: 17591682
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Kagawa University
• Principal Investigator: KAMANO Hiroshi Kagawa University, 保健管理センター, 教授 (60284337)
• Project Period (FY): 2005 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,820,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2005: ¥900,000 (Direct Cost: ¥900,000)
• Keywords: ewphotodynamictherapy / metalloporphyrin / 新光線力学療法 / 新光線力学 / 培養細胞

Research Abstract

新光線力学療法とは, 新しい光感受性物質13, 17-bis(1-carboxypropionyl) carbamoylethyl-3, 8-bis(1-decanyloxyethyl)-2, 7, 12, 18 tetramethyl-porphyrinato gallium, 又は, 誘導体を細胞に取り込ませ, 可視光線照射を行い, 細胞に変化を誘導する方法である。細胞に光感受性物質を添加し, 翌日, 光感受性物質を除去, 可視光線を照射し, 培養持続した。新しい光感受性物質の構造式の違いにより効果に差があることを見いだした。

Research Products

• [Journal Article] 13,17-BIS(1-CARBOXYPROPIONYL)CARBAMOYLETHYL-3,8-BIS(1-DECANYLOXYETHYL)-2,7,12,18-TETRAMETHYL-PORPHYRINATO GULLIUM(III) INDUCED THE DECREMENT OF THE HUMAN LEUKEMIA CELLS PROLIFERATION (2006)
  • Author(s): Kamano H, Kubota Y, Tanaka T, Okamato K, Sakata I
  • Journal Title: 28^<th> World Congress of Internal Medicine Pages: 281-281
• [Presentation] 13, 17-BIS(1-CARBOXYPROPIONYL) CARBAMOYLETHYL-3, 8-BIS(1-DECANYLOXYETHYL)-2, 7, 12, 18-TETRAMETHYL -PORPHYRINATO GALLIUM (III) TO THE TESTICULAR TUMOR AND OTHER CELLS (2009)
  • Author(s): Kamano H, Sakata I
  • Organizer: The 2nd World Congress on Controversies in Urology
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2009-02-07
• [Presentation] 13, 17-BIS(1-CARBOXYPROPIONYL)CARBAMOYLETHYL-3, 8-BIS(1-DECANYL0XYETHYL)-2, 7, 12, 18-TETRAMETHYL -PORPHYRINATO GALLIUM(III)TO THE TESTICULAR TUMOR AND OTHER CELLS (2009)
  • Author(s): Kamano H, Sakata I
  • Organizer: The 2nd World Congress on Controversies in Urology
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 2009-02-07
• [Presentation] 13, 17-BIS(1-CARBOXYPROPIONYL)CARBAMOYLETHYL-3, 8-BIS(1-DECANYLOXYETHYL)-2, 7, 12, 18-TETRAMETHYL-PORPHYRINATO GALLIUM (III) INDUCED THE DECREMENT OF THE HUMAN LEUKEMIA CELLS PROLIFERATION (2006)
  • Author(s): Kamano H, Kubota Y, Tanaka T, Okamato K, Sakata I
  • Organizer: 28^<th> World Congress of Internal Medicine
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2006-11-12