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Analysis of bioactive function of angiotensin II in prostate cancer

Research Project

Project/Area Number 17591689
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionYokohama City University Hospital

Principal Investigator

UEMURA Hiroji  Yokohama City University, Hospital, Dept. of Urology, Associate Professor, 附属病院, 準教授 (50244439)

Co-Investigator(Kenkyū-buntansha) YOSHINOBU Kubota  Yokohama City University, Sch. of Med, Dept. of Urology, Professor, 医学研究科, 教授 (10106312)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsAngiotensin II / Prostate cancer / 前立腺間質細胞
Research Abstract

Angiotensin II (Ang-II) plays a key role as a vasoconstrictor in controlling blood pressure and electrolyte/fluid homeostasis, and it has recently been shown that this peptide is a cytokine, especially acting as a growth factor in cardiovascular and stromal cells. In addition, the physiological function of Ang-II seems to be similar in prostate cancer and stromal cells. It is widely assumed that Ang-II facilitates the growth of both cells, and its receptor blockers (ARBs) have the potential to inhibit the growth of various cancer cells and tumors through the AT1 receptor. The mechanism of cell growth inhibition by ARBs has been considered to be suppression of the signal transduction systems activated by growth factors or cytokines in prostate cancer cells, and suppression of angiogenesis. This research may lead to develop the chemo-prevention or drug discovery of prostate cancer.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (29 results)

All 2006 2005

All Journal Article (29 results)

  • [Journal Article] Angiotensin II receptor blocker : possibility of antitumor agent for prostate cancer.2006

    • Author(s)
      H Uemura, H Ishiguro, Y Kubota
    • Journal Title

      Mini Rev Med Chem 6・7

      Pages: 835-844

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] An immunohistochemical scoring system of prolylisomerase Pin 1 for predicting relapse of prostate carcinoma after radical prostatectomy.2006

    • Author(s)
      T Sasaki, A Ryo, H Uemura, H Ishiguro, et al.
    • Journal Title

      Phathol Res Pract 202・5

      Pages: 357-364

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Renin-angiotensin system is an important factor in hormone refractory prostate cancer.2006

    • Author(s)
      H Uemura, Hisashi Hasumi, Hitoshi Ishiguro, Jun-ichi Teranishi, et al.
    • Journal Title

      Prostate 66・8

      Pages: 822-830

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Complete response, as determined by prostate-specific antigen level, to chlormadinone acetate withdrawal persisting longer than 2 years in patients with advanced prostate cancer : Two case reports.2006

    • Author(s)
      K Noguchi, J Teranishi, H Uemura, et al.
    • Journal Title

      Int J Urol. 13・9

      Pages: 1259-1261

    • NAID

      10018303628

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Complete response, as determined by prostate-specific antigen level, to chlormadinone acetate withdrawal persisting longer than 2 years in patients with advanced prostate cancer : Two case reports.2006

    • Author(s)
      K Noguchi, K Suzuki, J Teranishi, K Kondo, T Kishida, K Saito, H Uemura, et al.
    • Journal Title

      泌尿器科紀要 52・7

      Pages: 527-530

    • NAID

      10018303628

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] アンジオテンシンII受容体ブロッカーの理論と効果2006

    • Author(s)
      上村博司, 窪田吉信
    • Journal Title

      Urology View 4・2

      Pages: 50-53

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Angiotensin II receptor blocker : possibility of antitumor agent for prostate cancer.2006

    • Author(s)
      H Uemura, H Ishiguro, Y Kubota.
    • Journal Title

      Mini Rev Med Chem 6

      Pages: 835-844

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Complete response, as determined by prostate-specific antigen level, to chlormadinone acetate withdrawal persisting longer than 2 years in patients with advanced prostate cancer : Two case reports.2006

    • Author(s)
      K Noguchi, J Teranishi, H Uemura, N et al.
    • Journal Title

      Int J Urol. 13

      Pages: 1259-61

    • NAID

      10018303628

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Renin-angiotensin system is an important factor in hormone refractory prostate cancer.2006

    • Author(s)
      H Uemura, Hisashi Hasumi, Hitoshi Ishiguro, Jun-ichi Teranishi, Yasuhide Miyoshi, Yoshinobu Kubota.
    • Journal Title

      Prostate 66

      Pages: 822-830

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] An immunohistochemical scoring system of prolyl isomerase Pinl for predicting relapse of prostate carcinoma after radical prostatectomy.2006

    • Author(s)
      Sasaki T, Ryo A, Uemura H, et al.
    • Journal Title

      Pathol Res Pract. 202

      Pages: 357-64

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] An immunohistochemical scoring system of prolylisomerase Pin 1 for predicting relapse of prostate carcinoma after radical prostatectomy.2006

    • Author(s)
      T Sasaki, A Ryo, H Uemura, H, Ishiguro, et al.
    • Journal Title

      Phathol Res Pract 202・5

      Pages: 357-364

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Complete response, as determined by prostate-spedfic antigen lvel, to chlormadinone acetate withdrawal persisting longer than 2 years in patients with advanced prostate cancer : Two case reports.2006

    • Author(s)
      K Noguchi, J Teranishi, H Uemura, et al.
    • Journal Title

      Int J Urol. 13・9

      Pages: 1259-61

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Antiproliferative efficacy of angiotensin II receptor blocker for prostate cancer.2005

    • Author(s)
      H.Uemura, N Nakaigawa, H Ishiguro, Y Kubota.
    • Journal Title

      Curr Cancer Drug Target. 5

      Pages: 307-323

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Antiproliferative activity of angiotensin II receptor blocker through cross-talk between stromal and epithelial prostate cancer cells.2005

    • Author(s)
      H Uemura, H Ishiguro, Y Nagashima, T Sasaki, H Hasumi, S Kato, Y Kubota.
    • Journal Title

      Mol Cancer Therap. 4

      Pages: 1699-1709

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary 2005 Annual Research Report
  • [Journal Article] Pilot study of angiotensin II receptor blocker in advanced hormone refractory prostate cancer.2005

    • Author(s)
      H Uemura, H Hasumi, T Kawahara, S Sugiura, Y Miyoshi, N Nakaigawa, J Teranishi, K Noguchi, H Ishiguro, Y Kubota.
    • Journal Title

      Int J Clin Oncol. 10

      Pages: 405-410

    • NAID

      10017131932

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Stable suppression of tumorigenicity by Pin1-targetted small interfering RNA in prostate cancer.2005

    • Author(s)
      Ryo, A., Uemura, H., Ishiguro, H., Perrem, K., Kubota, Y, Aoki, I.
    • Journal Title

      Clinc.Cancr Res. 11

      Pages: 7523-7531

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Usefulness of ultrasensitive PSA assay for early detection of biochemical failure after radical prostatectomy.2005

    • Author(s)
      M Nakamura, Y Miyoshi, S Sugiura, K Fujinami, M Yao, Y Kubota, H Uemura.
    • Journal Title

      Int.J.Urol. 12

      Pages: 1050-1054

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Angotensin ii blocker reduced serum psa in hormone refractory prostate cancer.2005

    • Author(s)
      T Yamagishi, H Uemura, N Nakaigawa, K Noguchi, Y Kubota.
    • Journal Title

      J Urol. 173

      Pages: 441-441

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Neuroserpin (pi-12) is up-regulated in high-grade prostate2005

    • Author(s)
      H Hasumi, H Ishiguro, M Nakamura, S Sugiura, Y Osada, Y Miyoshi, K Fujinami, M Yao, Y Kubota, H Uemura.
    • Journal Title

      Int.J.Cancer 115

      Pages: 911-916

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Receptor for advanced Glycation End Products (RAGE) and its Ligand, Amphoterin, are Overexpressed and Associated with prostate cancer progression.2005

    • Author(s)
      H Ishiguro, H Uemura, N Nakaigawa, Y Miyoshi, K Fujinami, Y Kubota.
    • Journal Title

      Prostate 64

      Pages: 92-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Treatment of androgen-independent, hormone-refractory prostate cancer with docetaxel in Japanese patients.2005

    • Author(s)
      Y Miyoshi, H Uemura, M Nakamura, H Hasumi, S Sugiura, K Makiyama, N Nakaigawa, T Kishida, T Ogawa, M Yao, Y Kubota.
    • Journal Title

      Int J Clin Oncol. 10

      Pages: 182-6

    • NAID

      10016477275

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyl transferase in prostate cancer. Prostate Ca2005

    • Author(s)
      Y Miyoshi, H Uemura, H Ishiguro, H Kitamura, N Nomura, PV Danenberg, Y Kubota.
    • Journal Title

      Prostate Dis 8

      Pages: 260-265

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Prostate cancer : a comparative study of (11)C-choline PET and MR imaging combined with proton MR spectroscopy.2005

    • Author(s)
      Yamaguchi T, Lee J, Uemura H, Sasaki T, Takahashi N, Oka T, Shizukuishi K, Endou H, Kubota Y, Inoue T.
    • Journal Title

      Eur J Nucl Med Mol Imaging. 32

      Pages: 742-748

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Genistein induces cell growth inhibition in prostate cancer through the suppression of telomerase activity.2005

    • Author(s)
      H Ouchi, H Ishiguro, N Ikeda, M Hori, Y Kubota, H Uemura.
    • Journal Title

      Int.J.Urol. 12

      Pages: 73-80

    • NAID

      10014374307

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Antiproliferative efficacy of angiotensin II receptor blocker for prostate cancer.2005

    • Author(s)
      H.Uemura, N Nakaigawa, H Ishiguro, Y Kubota
    • Journal Title

      Curr Cancer Drug Target. 5

      Pages: 307-323

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Pilot study of angiotensin II receptor blocker in advanced hormone refractory prostate cancer.2005

    • Author(s)
      H Uemura, H Hasumi, et al.
    • Journal Title

      Int J Clin Oncol. 10

      Pages: 405-410

    • NAID

      10017131932

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Angotensin ii blocker reduced serum psa in hormone refractory prostate cancer.2005

    • Author(s)
      T Yamagishi, H Uemura, N Nakaigawa K Noguchi, Y Kubota.
    • Journal Title

      J Urol. 173

      Pages: 441-441

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Stable suppression of tumorigenicity by Pin1-targetted small interfering RNA in prostate cancer.2005

    • Author(s)
      Ryo, A., Uemura, H., Ishiguro, H., Perrem, K., Kubota, Y., Aoki, I.
    • Journal Title

      Clinc.Cancr Res. 11

      Pages: 7523-7531

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Neuroserpin (pi-12) is up-regulated in high-grade prostate cancer and is associated with survival.2005

    • Author(s)
      H Hasumi, H Ishiguro, M Nakamura, S Sugiura, Y Osada, Y Miyoshi, K Fujinami, M Yao, Y Kubota, H Uemura.
    • Journal Title

      Int.J.Cancer 115

      Pages: 911-916

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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