| Project/Area Number |
17591695
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
OKIHARA Koji Kyoto Prefectural University of Medicine, Graduate School of Medicine, Associate Professor, 医学研究科, 講師 (80285270)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Terukazu Kyoto Prefectural University of Medicine, Graduate School of Medicine, Assistant Professor, 医学研究科, 助教 (10381964)
MIKAMI Kazuya Kyoto Prefectural University of Medicine, Graduate School of Medicine, Assistant Professor, 医学研究科, 助教 (10291585)
MIZUTANI Yoichi Kyoto Prefectural University of Medicine, Graduate School of Medicine, Associate Professor, 医学研究科, 准教授 (10243031)
KAWAUCHI Akihiro Kyoto Prefectural University of Medicine, Graduate School of Medicine, Associate Professor, 医学研究科, 准教授 (90240952)
MIKI Tsuneharu Kyoto Prefectural University of Medicine, Graduate School of Medicine, Professor, 医学研究科, 教授 (10243239)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥2,900,000 (Direct Cost: ¥2,900,000)
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| Keywords | Benign prostatic hyperplasia / Prostate cancer / bladder outlet obstruction / Ultrasound / Radical prostatectomy / Urinary disorder / Urinary incontinence |
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| Research Abstract |
We assessed the clinical efficacy of real-time voiding transrectal ultrasound examination with the aim that this novel method can be feasible in evaluating urinary function. This ultrasound system using the specific small-type trasnrectal probe can be navigated the dynamic change of the prostatic urethra as well as the membrounous urethra. First, we analyzed the manner of opening and closing pattern in the prostatic and membrounous urethra in the cases without bladder outlet obstruction. In men without bladder outlet obstruction, bladder neck opened immediately in the early phase of micturition, and the prostatic as well as the membrounous urethra with the diameter measuring from 2 to 3 cm opened continuously until the ending phase of the micturition. The diameter of the urethra was tapered proportionally. There was no significant difference in each section of the diameter as well as of the opening velocity in the urethra which was located apart from 1 cm at the bladder neck. In additi
… More
on, maximum flow rate in the examination of the uroflowmetry was associated with the opening diameter of the bladder neck. In patients with benign prostatic hyperplasia who were suffering from bladder outlet obstruction, it was difficult to navigate all the section of the urethra, and was impossible to measure the diameter of the urethra on the navigation time between 12 and 16 seconds. The time for dilating the bladder neck was delayed compared to those without bladder outlet obstruction, and the diameters in the each section were opened completely 8 seconds after the navigation. In prostate cancer patients who were underwent radical prostatectomy and had no symptoms for bladder outlet obstruction, the bladder neck opened prior to the micturition, and the lengths for the membrounous urethra were significantly short in cases with urinary incontinence and/or urethral stricture than in those without bladder outlet obstruction. Specifically, in the normal control cases in men with radical prostatectomy, the opening and closing manner in the urethra was quite similar to that in the normal cases without the surgery of radical prostatectomy. Less
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