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Clonality analysis of anti-HLA antibodies involved in chronic allograft rejection

Research Project

Project/Area Number 17591699
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKitasato University

Principal Investigator

OBATA Fumiya  Kitasato University, 医療衛生学部, 教授 (60129236)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Kazunari  北里大学, 医学部, 准教授 (10174921)
Project Period (FY) 2005 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,880,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywords腎移植 / 慢性拒絶反応 / 抗HLA 抗体 / 抗HLA抗体 / Flow PRA / Western Blot / PRA / 血清クレアチニン / フローPRA / クレアチン
Research Abstract

腎移植後に出現する抗HLA 抗体の変動と拒絶反応との関連性を調べるため、抗HLA class I/class II、IgG/IgM 各抗体を経時的に解析した。その結果、(1) 抗体陽性維持・出現・消失の各症例において、これらの抗体のほぼ全ての組み合わせパターンが観察された。(2) 抗体陰性維持群においても陽性群(維持・出現・消失)においても、血清クレアチニン値は低値または中間値を維持する症例が多かった。(3) クレアチニン値の悪化に先立って、抗HLA抗体の出現が検出された症例が観察された。

Report

(5 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • 2005 Annual Research Report
  • Research Products

    (16 results)

All 2008 2007 2006 2005

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (8 results) Book (2 results)

  • [Journal Article] Hydrogen peroxide increases interleukin-12 p40/p70 molecular ratio and induces Th2-predominantresponses in mice2006

    • Author(s)
      Obata F, Hoshino A, Toyama A.
    • Journal Title

      Scand J Immunol 63(2)

      Pages: 125-130

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen peroxide increases interleukin-12 p40/p70 molecular ratio and induces Th2-predominant responses in mice2006

    • Author(s)
      Obata F, et al.
    • Journal Title

      Scand J Immunol 63・2

      Pages: 125-130

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Expression of stress-related genes in a cadmium-resistant A549 human cell line2005

    • Author(s)
      Croute F, Beau B, Murat JC, Vincent C, Komatsu H, Obata F, Soleilhavoup JP.
    • Journal Title

      J Toxicol Environ Health A. 68(9)

      Pages: 703-718

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of CD4+ and CD8+T-cells and interferon-gamma to the progress of chronic rejection of kidney allografts : The Th1 response mediates both acute and chronic rejection2005

    • Author(s)
      Obata F, Yoshida K, Ohkubo M, Ikeda Y, Taoka Y, Takeuchi Y, Shinohara N, Endo T,Baba S.
    • Journal Title

      Transplant Immunol 14(1)

      Pages: 21-25

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of CD4^+ and CD8^+T-cells and interferon-gamma to the progress ofchronic rejection of kidney allografts : The Th1 response mediates both acute and chronic rejection.2005

    • Author(s)
      Obata F, et al.
    • Journal Title

      Transplant Immunol 14・1

      Pages: 21-25

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Expression of stress-related genes in a cadmium-resistant A549 human cell line.2005

    • Author(s)
      Croute F, et al.
    • Journal Title

      J Toxicol Environ Health 68・9

      Pages: 703-718

    • Related Report
      2005 Annual Research Report
  • [Presentation] Correlation analysis among serum anti HLA antibodies, CD4+, CD8+, and CD19+ cells in renal allografts2008

    • Author(s)
      Obata F, Yoshida K, Takeuchi Y, Tsuchida M, Endo T, Baba S.
    • Organizer
      XXII International Congress of The Transplantation Society
    • Place of Presentation
      Sydney
    • Year and Date
      2008-08-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Correlation analysis among serum anti HLA antibodies, CD4^+, CD8^+, and CD19^+ cells in renal allografts.2008

    • Author(s)
      Obata F
    • Organizer
      XXII International Congress of The Transplantation Society
    • Place of Presentation
      Sydney
    • Year and Date
      2008-08-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] ABO不適合腎移植患者における抗体関連拒絶の1例2007

    • Author(s)
      平山貴博、吉田一成、小幡文弥、竹内康雄、小池淳樹、遠藤忠雄、馬場志郎
    • Organizer
      第43回日本移植学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2007-11-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 血漿交換とステロイド療法に低容量Rituximab併用投与にて長期改善を認めた抗体関連拒絶反応の1例2007

    • Author(s)
      吉田一成、竹内康雄、若井陽希、馬場志郎、小池淳樹、小幡文弥
    • Organizer
      第16回日本組織適合性学会大会
    • Place of Presentation
      東京
    • Year and Date
      2007-09-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 腎移植患者における抗HLA抗体の変動解析?第2報2006

    • Author(s)
      比佐華菜子、吉田一成、竹内康雄、遠藤忠雄、馬場志郎、小幡文弥
    • Organizer
      第15回日本組織適合性学会大会
    • Place of Presentation
      東京
    • Year and Date
      2006-09-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 腎移植患者における抗HLA抗体の変動に関する解析?第2報2006

    • Author(s)
      小幡文弥、吉田一成、土田繭美、竹内康雄、遠藤忠雄、馬場志郎
    • Organizer
      第42回日本移植学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2006-09-09
    • Related Report
      2008 Final Research Report
  • [Presentation] 腎移植患者における抗HLA抗体の変動に関する解析2005

    • Author(s)
      小幡文弥、吉田一成、竹内康雄、大久保みどり、遠藤忠雄、馬場志郎
    • Organizer
      第41回日本移植学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2005-10-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 腎移植患者における抗HLA抗体の変動解析2005

    • Author(s)
      松井由紀子、吉田一成、竹内康雄、大久保みどり、遠藤忠雄、馬場志郎、小幡文弥
    • Organizer
      第14回日本組織適合性学会大会
    • Place of Presentation
      熊本
    • Year and Date
      2005-10-03
    • Related Report
      2008 Final Research Report
  • [Book] 新規キナーゼ様分子LRRK2の機能解析ブレインサイエンスレビュー2008(伊藤正男、川合述史編)2008

    • Author(s)
      小幡文弥
    • Publisher
      クバクロ、東京
    • Related Report
      2008 Final Research Report
  • [Book] ブレインサイエンスレビュー2008分担課題 : 新規キナーゼ様分子LRRK2の機能解析2008

    • Author(s)
      小幡文弥
    • Total Pages
      229
    • Publisher
      クバクロ(東京)
    • Related Report
      2008 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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