| Project/Area Number |
17591709
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Hokkaido University |
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Principal Investigator |
MINAKAMI Hisanori Hokkaido University, Grad. School of Med., Professor (40102256)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Takashi Hollaido Univ, Hospital, Assistant Professor (20374283)
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| Project Period (FY) |
2005 – 2007
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| Project Status |
Completed (Fiscal Year 2007)
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| Budget Amount *help |
¥3,570,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2006: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2005: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | twin pregnancy / Twin-t-Twin transfusion syndorme / monochorionic twin / registration system / multi-center collaborate study / infantile prognosis / assisted reproductive technology / clomiphene citrate / 胎児間輸血症候群 / 周産期死亡率 / 周産期罹病率 / 周産期医療ネットワーク / 前方視的コホート研究 / 発症頻度 |
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| Research Abstract |
It is important for all obstetrician-gynecologists to realize or know the vital statistics of worth prognosis of twin pregnancies in improving the prognosis of twin pregnancies. We started the system of registration of twin pregnancies diagnosed before 15^<th> week of gestation in Hokkaido in Apr. 2005. At the end of March, 2007, 339 women with twin pregnancies were enrolled and registered. Of 339 twin pregnancies, 235(69.3%) 97(28.6%), and 4(1.2%) were dichorionic diamniotic, monochorioic diamniotic, and monochorionic monoamniotic, respectively, after excluding 3 cases with unknown chorionicity. Twin pregnancies established after treatment for infertility accounted for 125(36.9%) cases, including 61 cases after IVF-ET, 35 cases after clomiphene citrate, and 29 after hMG-hCG. Thus, it was clarified that an approximately one third of twin pregnancies were established after treatment of infertility in current Hokkaido. Gestational age at deliveries was known in 168 cases. Preterm deliveries before 33 weeks of gestation occurred more frequently in monochorionic twins than in dichorionic twins (9/46 [19.6%] vs. 11/122 [9.0%] These figures were apparently worse compared with that of an approximately 0.8% of singleton pregnancies. Because these information on the results of analysis were released to all obstetricians-gynecologists participating in this registration system, early referral of twin pregnancies to the secondary or tertiary hospitals appeared to be promoted after the establishment of this system, These movement may contribute to improve the prognosis of twin pregnancies in Hokkaido.
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