| Project/Area Number |
17591713
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
ITO Kiyoshi TOHOKU UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 大学院医学系研究科, 助教授 (70241594)
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| Co-Investigator(Kenkyū-buntansha) |
YAEGASHI Nobuo Tohoku University, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院医学系研究科, 教授 (00241597)
SASANO Kiminobu Tohoku University, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院医学系研究科, 教授 (50187142)
HAYASHI Shinichi Tohoku University, SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (60144862)
SUZUKI Takashi Tohoku University, GRADUATE SCHOOL OF MEDICINE, RESEARCH ASSOCIATE, 大学院医学系研究科, 助手 (10261629)
TAMURA Mitsutoshi Tohoku University, HOSPITAL, RESEARCH ASSOCIATE, 病院・助手 (90292325)
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| Project Period (FY) |
2005 – 2006
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| Project Status |
Completed (Fiscal Year 2006)
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| Budget Amount *help |
¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥2,300,000 (Direct Cost: ¥2,300,000)
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| Keywords | Endometrial cancer / Breast cancer / Progesterone receptor / Estrogen / Cyclin B1 / CDC2 / Hormone replacement therapy / 癌 / 酵素 / シグナル伝達 / 臨床 / 遺伝子 |
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| Research Abstract |
This study aims to investigate whether the biological role of estrogen and progestin in tumorigenesis are different between the endometrium and breast. The possible role of specific progesterone receptor (PR) isoforms (PRA and PRB) as predictive factors in endometrial and breast carcinomas is unclear. This study was undertaken to evaluate the clinical significance of intratumoral PR isoforms status in patients with endometrioid endometrial and breast carcinomas. We found that cases that were negative for either one or both of the PR isoforms were significantly associated with shorter disease-free and overall survival of the patients. In addition, multivariate analysis demonstrated that an absence of PRA immunoreactivity was an independent risk factor in disease-free survival of the patients. The results of our study indicate that the loss of expression of PR isoforms, especially expression of PRA, may result in aggressive biological characteristics in human endometrioid endometrial carcinoma that can play important roles in the prognosis and/or recurrence, in these patients. In contrast, breast carcinoma patients with PRA-rich tumors were generally considered to be associated with poorer disease-free survival rates. These results indicate that the biological significance of PR isoforms differ markedly between endometrial and breast carcinomas.
In addition, microarray analyses of human breast and endometrial cancer cells revealed that there are large amount of differences between them, regarding estrogen and progestin responsive gene expression.
Especially, cell cycle related genes, cyclin B and CDC, expressed differently between them.
These data suggest that the biological roles of estrogen and progestin in tumorigenesis are certainly different between the endometrium and breast, although both are considered "estrogen-dependent tissues".
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