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Functional analysis of cholesterol sulfate in interaction between embryo and endometrium.

Research Project

Project/Area Number 17591717
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionThe University of Tokyo

Principal Investigator

MOMOEDA Mikio  The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (50221627)

Co-Investigator(Kenkyū-buntansha) HIROI Hisahiko  The University of Tokyo, Faculty of Medicine, Assistant Professor, 医学部附属病院, 助手 (10343138)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2005: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywordscell and tissue / embryogenesis / implantation / endometrium / gene
Research Abstract

We have studied on a tempo-spatial control of embryo implantation to uterine endometrium, demonstrating that the content of cholesterol sulfate(CS) in endometrium increases transiently during implantation period, the increase of CS is observed only in peri-implantation region, and CS inhibits the invasion of trophoblast to endometrium. In this study, we aimed to elucidate the function of CS synthesis in interaction between embryo and endometrium during implantation.
1.It became clear that CS inhibit MMP activity as well as plasmin activity in the culture medium of endometrial cell culture system. We suggest that CS plays an important role in regulating a protease activity in vivo during implantation.
2.CS promoted gene expression of RevErb regarded as a target gene of ROR in an endometrial cell. In addition, CS promoted gene expression of ROR which was the receptor of CS.
3.In JEG which was cell line of trophoblast, CS stimulated a progesterone production. We reviewed action of CS on gene expression of enzymes associated with a progesterone production, suggesting no effect on them. Now we are examining the affinity of CS for cholesterol transportation protein.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (3 results)

All 2006

All Journal Article (3 results)

  • [Journal Article] Elevated serum bisphenol A levels under hyperandrogenic conditions may be caused by decreased UDP-glucuronosyltransferase activity.2006

    • Author(s)
      Takeuchi T, Tsutsumi O, Ikezuki Y, Kamei Y, Osuga Y, Fujiwara T, Takai Y, Momoeda M, Yano T, Taketani Y
    • Journal Title

      Endocrine Journal 53(4)

      Pages: 485-485

    • NAID

      10019269724

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Elevated serum bisphenol A levels under hyperandrogenic conditions may be caused by decreased UDP-glucuronosyltransferase activity.2006

    • Author(s)
      Takeuchi T, Tsutsumi O, Ikezuki Y, Kamei Y, Osuga Y, Fujiwara T, Takai Y, Momoeda M, Yano T, Taketani Y.
    • Journal Title

      Endocrine Journal 53(4)

      Pages: 485-485

    • NAID

      10019269724

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Elevated serum bisphenol A levels under hyperandrogenic conditions be caused by decreased UDP-glucuronosyltransferase activity.2006

    • Author(s)
      Takeuchi T, Tsutsumi O, Ikezuki Y, Kamei Y, Osuga Y, Fujiwara T, Takai Y, Momoeda M, Yano T, Taketani Y.
    • Journal Title

      Endocrine Journal 53(4)

      Pages: 485-485

    • Related Report
      2006 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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