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Basic research of cell proliferation and apoptosis through p53/PTEN/Ras pathway

Research Project

Project/Area Number 17591720
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionThe University of Tokyo

Principal Investigator

YASUGI Toshiharu  The University of Tokyo, Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (20251267)

Co-Investigator(Kenkyū-buntansha) ODA Katsutoshi  The University of Tokyo, Faculty of Medicine, Assistant, 医学部附属病院, 助手 (30359608)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2005: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsendometrial carcinomas / p53 / tumor suppressor protein / prognosis / PI3K pathway
Research Abstract

Two types of endometrial cancer have been described In previous studies. Type 1 endometrial cancer is characterized as estrogen dependent with excellent prognosis, and type 2 as estrogen independent with poor prognosis. PTEN mutations occur at high frequency in endometrial carcinomas. Although It had been controversial whether PTEN mutation is associated with prognosis, we previously reported that PTEN mutation only outside exons 5-7 is a favorable prognostic factor in endometrial carcinomas. Over expression of p53 is also frequent and contributes to the poor survival in endometrial carcinomas. Mutations or amplifications of PIK3CA. which encodes the catalytic subunit of PI3K, have been reported in many human cancers.
To elucidate the relationship between PTEN mutation and p53 overexpression, we analyzed PTEN, p53 status and estrogen receptor and progesterone receptor. We also assessed PIK3CA status in endometrial carcinomas.
In the series of study, we show the absence of P53 overexpression, PTEN mutations and clinical stage are favorable and independent prognostic factors in endometrial carcinomas. We also reported frequent coexistence of PIK3CA and PTEN mutations in endometrial carcinomas. Moreover we show that PIK3CA copy number may change in endometrial carcinomas.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (15 results)

All 2007 2006 2005

All Journal Article (15 results)

  • [Journal Article] Treatment with paclitaxel plus carboplatin, alone or with irradiation, of advanced or recurrent endometrial carcinoma.2007

    • Author(s)
      Arimoto T, Nakagawa S, Yasugi T, Yoshikawa H, Kawana K, Yano T, Taketani Y
    • Journal Title

      Gynecol Oncol 104(1)

      Pages: 32-35

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Combined phospho-Akt and PTEN expressions associated with post-treatment hysterectomy after conservative progestin therapy in complex atypical hyperplasia and stage Ia, G1 adenocarcinoma of the endometrium.2007

    • Author(s)
      Minaguchi T, Nakagawa S, Takazawa Y, Nei T, Horie K, Fujiwara T, Osuga Y, Yasugi T, Kugu K, Yano T, Yoshikawa H, Taketani Y
    • Journal Title

      Cancer Lett 248(1)

      Pages: 112-122

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Treatment with paclitaxel plus carboplatin, alone or with irradiation, of advanced or recurrent endometrial carcinoma.2007

    • Author(s)
      Arimoto T, Nakagawa S, Yasugi T, Yoshikawa H, Kawana K, Yano T, Taketani Y.
    • Journal Title

      Gynecol Oncol 104(1)

      Pages: 32-35

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Combined phospho-AKt and PTEN expressions associated with post-treatment hysterectomy after conservative progestin therapy in complex atypical hyperplasia and stage Ia, G1 adenocarcinoma of the endometrium.2007

    • Author(s)
      Minaguchi T, Nakagawa S, Takazawa Y, Nei T, Horie K, Fujiwara T, Osuga Y, Yasugi T, Kugu K, Yano T, Yoshikawa H, Taketani Y.
    • Journal Title

      Cancer Lett. Apr 8,248(1)

      Pages: 112-122

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Combined phospho-Akt and PTEN expressions associated with post-treatment hysterectomy after conservative progestin therapy in complex atypical hyperplasia and stage Ia, G1 adenocarcinoma of the endometrium.2007

    • Author(s)
      Minaguchi T, Nakagawa S, Takazawa Y, Nei T, Horie K, Fujiwara T, Osuga Y, Yasugi T, Kugu K, Yano T, Yoshikawa H, Taketani Y.
    • Journal Title

      Cancer Lett 248(1)

      Pages: 112-122

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 3-D fractal tumor growth of epithelial ovarian cancer.2006

    • Author(s)
      Kikuchi A, Kozuma S, Yasugi T, Taketani Y
    • Journal Title

      Eur J Gynaecol Oncol 27(6)

      Pages: 561-565

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Do we need a different strategy for HPV screening and vaccination in East Asia?2006

    • Author(s)
      Miura S, Matsumoto K, Oki A, Satoh T, Tsunoda H, Yasugi T, Taketani Y, Yoshikawa H
    • Journal Title

      Int J Cancer 119(11)

      Pages: 2713-2715

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] 3-D fractal tumor growth of epithelial ovarian cancer.2006

    • Author(s)
      Kikuchi A, Kozuma S, Yasugi T, Taketani Y.
    • Journal Title

      Eur J Gynaecol Oncol 27(6)

      Pages: 561-565

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Annual Research Report 2006 Final Research Report Summary
  • [Journal Article] Do we need a different strategy for HPV screening and vaccination in East Asia?2006

    • Author(s)
      Miura S, Matsumoto K, Oki A, Satoh T, Tsunoda H, Yasugi T, Taketani Y, Yoshikawa H.
    • Journal Title

      Int J Cancer Dec 1,119(11)

      Pages: 2713-2715

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Do we need a different strategy for HPV screening and vaccination in East Asia?2006

    • Author(s)
      Miura S, Matsumoto K, Oki A, Satoh T, Tsunoda H, Yasugi T, Taketani Y, Yoshikawa H.
    • Journal Title

      Int J Cancer 119(11)

      Pages: 2713-2715

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Methylation and expression analysis of 15 genes and three normally-methylated genes in 13 Ovarian cancer cell lines.2006

    • Author(s)
      Imura M, Yamashita S, Cai LY, Furuta JI, Wakabayashi M, Yasugi T, Ushijima T.
    • Journal Title

      Cancer Letters 19(印刷中)

    • Related Report
      2005 Annual Research Report
  • [Journal Article] IgG antibodies to HPV16, 52, 58 and 6 L1-capsids and spontaneous regression of cervical intraepithelial neoplasia.2006

    • Author(s)
      Matsumoto K, Yasugi T, Oki A, Fujii T, Nagata C, Sekiya S, Hoshiai H, Taketani Y, Kanda T, Kawana T, Yoshikawa H.
    • Journal Title

      Cancer Letters 18

      Pages: 309-313

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6.2006

    • Author(s)
      Matsumoto Y, Nakagawa S, Yano T, Takizawa S, Nagasaka K, Nakagawa K, Minaguchi T, Wada O, Ooishi H, Matsumoto K, Yasugi T, Kanda T, Huibregtse JM, Taketani Y.
    • Journal Title

      Journal of Medical Virology 78(4)

      Pages: 501-507

    • Related Report
      2005 Annual Research Report
  • [Journal Article] The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha.2005

    • Author(s)
      Wada-Hiraike O, Yano T, Nei T, Matsumoto Y, Nagasaka K, Takizawa S, Oishi H, Arimoto T, Nakagawa S, Yasugi T, Kato S, Taketani Y.
    • Journal Title

      British Journal of Cancer 92(12)

      Pages: 2286-2291

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Comparison between conventional surgery and radiotherapy for FIGO stage I-II cervical carcinoma : a retrospective Japanese study2005

    • Author(s)
      Yamashita H, Nakagawa K, Tago M, Shiraishi K, Nakamura N, Ohtomo K, Oda K, Nakagawa S, Yasugi T, Taketani Y.
    • Journal Title

      Gynecologic Oncology 97(3)

      Pages: 834-839

    • Related Report
      2005 Annual Research Report

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Published: 2005-04-01   Modified: 2016-04-21  

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