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Analysis of Prognostic Factors in Head and Neck Squamous Cell Carcinoma Patients Treated with Docetaxel and Concurrent Radiotherapy

Research Project

Project/Area Number 17591773
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

ORIDATE Nobuhiko (2006)  Hokkaido Univ., Hokkaido University Hospital, Lec., 病院, 講師 (90312355)

樋口 栄作 (2005)  北海道大学, 病院, 助手 (30374424)

Co-Investigator(Kenkyū-buntansha) FURUTA Yasushi  Hokkaido Univ., Grad.School of Med., Asso.Prof., 大学院医学研究科, 助教授 (60261301)
折舘 伸彦  北海道大学, 病院・助手 (90312355)
Project Period (FY) 2005 – 2006
Project Status Completed (Fiscal Year 2006)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2005: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsHead and neck cancer / docetaxel / Radiation therapy / Prognostic factors / Molecular markers / 頭頚部癌 / ドセタキセル / 再発予測因子
Research Abstract

The semi-synthetic taxane, docetaxel, has demonstrated significant anti-tumor activity in head and neck squamous cell carcinoma (HNSCC) and is thought to enhance tumor radiosensitivity. However, molecular markers that might be of use in pre icting the prognosis and sensitivity of HNSCC patients to docetaxel and radiotherapy treatment have not yet been reported. The current study aimed to address this issue and evaluate the significance of the cell-cycle-control proteins cyclin D1 and p16 as prognostic markers. Cyclin D1 and/or p16 protein expression was retrospectively evaluated by immunohistochemistry in 53 head and neck cancer patients who were treated with 10 mg/m2/week docetaxel four to six times and received concurrent chemoradiotherapy (total radiation therapy dose 65-66 Gy) over a 6.5-8 week period. Kaplan-Meier univariate analysis revealed that patients with cyclin D1-positive tumors or p16-negative tumors had a worse prognosis compared with those with cyclin Dl-negative tumors or p16-positive tumors (p=0.0004 and p=0.025, respectively). The prognostic significance of cyclin D1 expression was also confirmed using a proportional hazard regression model.

Report

(3 results)
  • 2006 Annual Research Report   Final Research Report Summary
  • 2005 Annual Research Report
  • Research Products

    (10 results)

All 2007 2006 2005 Other

All Journal Article (10 results)

  • [Journal Article] Prognostic significance of cyclin d1 and p16 in patients with intermediate risk head and neck squamous-cell carcinoma treated with docetaxel and concurrent radiotherapy.2007

    • Author(s)
      Higuchi E, Oridate N, Homma A, Suzuki F, Atago Y, et al.
    • Journal Title

      Head and Neck (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Prognostic significance of cyclin d1 and p16 in patients with intermediate risk head and neck squamous-cell carcinoma treated with docetaxel and concurrent radiotherapy.2007

    • Author(s)
      Higuchi E, Oridate N, Homma A, Suzuki F, Atago Y, Nagahash T, Furuta Y, Fukuda S
    • Journal Title

      Head and Neck (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] "Watch-and-see" policy for the clinically positive neck in head and neck cancer treated with chemoradiotherapy.2006

    • Author(s)
      Homma A, Furuta Y, Oridate N, Suzuki F, Higuchi E, et al.
    • Journal Title

      Int J Clin Oncol 11

      Pages: 441-448

    • NAID

      10020571777

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] "Watch-and-see" policy for the clinically positive neck in head and neck cancer treated with chemoradiotherapy.2006

    • Author(s)
      Homma A, Furuta Y, Oridate N, Suzuki F, Higuchi E, Nishioka T, Shirato H, Nagahashi T, Yagi K, Fukuda S
    • Journal Title

      Int J Clin Oncol 11

      Pages: 441-448

    • NAID

      10020571777

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin2005

    • Author(s)
      Oridate N, Kim H-J, Xu X, Lotan R
    • Journal Title

      Cancer Biol Ther 4

      Pages: 318-323

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Rapid superselective high-dose cisplatin infusion with concomitant radiotherapy for advanced head and neck cancer.2005

    • Author(s)
      Homma A, Furuta Y, Suzuki F, Oridate N, et al.
    • Journal Title

      Head Neck 27

      Pages: 65-71

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Prognostic significance of cytoplasmic macrophage migration inhibitory factor expression in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy.2005

    • Author(s)
      Suzuki F, Nakamaru Y, Oridate N, Homma A, et al.
    • Journal Title

      Oncol Rep 13

      Pages: 59-64

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin.2005

    • Author(s)
      Oridate N, Kim H-J, Xu X, Lotan R.
    • Journal Title

      Cancer Biol Ther 4

      Pages: 318-323

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary
  • [Journal Article] Laryngeal zoster mimicking a laryngeal cancer2005

    • Author(s)
      Higuchi E, Nakamaru Y, Ohwatari R, Sakashita T, Mesuda Y, Homma A, Furuta Y, Fukuda S.
    • Journal Title

      Otolaryngol Head Neck Surg. 133

      Pages: 647-647

    • Related Report
      2005 Annual Research Report
  • [Journal Article] Prognostic significance of cyclin dl and p16 in patients with intermediate risk head and neck squamous-cell carcinoma treated with docetaxel and concurrent radiotherapy.

    • Author(s)
      Higuchi E, Oridate N, Homma A, Suzuki F, Atago Y, et al.
    • Journal Title

      Head and Neck (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2006 Final Research Report Summary

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Published: 2005-04-01   Modified: 2016-04-21  

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