| Budget Amount *help |
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2006: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2005: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Research Abstract |
A system to evaluate functional localization in the brain corresponding to the vestibular stimulation was developed. In this system, a electro-encephalogram (EEG) and a functional near infrared spectroscopy (fNIRS) were simultaneously recorded and analyzed during vertigo elicited by the vestibular stimulations, which were made by the cold and hot air.
Two characteristic responses of blood flow, evaluated by the oxidized hemoglobin, were observed after the cold and warm caloric stimulation for two to four minutes. One was simple increase of the blood flow, observed in the parietal and temporal area of the brain, the other was two phase response of the blood flow in the frontal area, in which at first the blood flow decreased just after the vestibular stimulation and then it increased when the test subject felt vertigo.
These remarkable blood flow responses were observed in very wide area in the brain, such as precentral gyrus, frontoparietal operculum, frontal pole, postcentral gyrus, supramarginal gyrus, superior parietal lobule and superior temporal gyrus, the localization of which almost corresponded to those of the previous reports evaluated by other methods.
The EEG responses during the vestibular stimulation indicated a burst of θ-wave and increase of the power spectrum corresponding to the θ-wave by the frequency analysis, which might suggest that the increase of brain activity according to the vertigo elicited by the vestibular stimulation.
These results indicated that the simultaneous recording of the fNIRS and EEG could detect the activity of the cerebral cortex according to the vertigo and that our method could provide very useful clinical information for diagnosis and treatment of the peripheral vertiginous diseases.
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